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Your search keyword '"Ekinci, Özgür"' showing total 4 results
Start Over Author "Ekinci, Özgür" Publisher sage publications
4 results on '"Ekinci, Özgür"'

2. High-Risk CD117-Positive Gastrointestinal Stromal Tumor of the Colon in a 12-Year-Old Girl: Adjuvant Treatment with Imatinib Mesylate

Author

PINARLI, FARUK GÜÇLÜ, EKİNCİ, ÖZGÜR, OĞUZ, AYNUR, Ozen, Onur, KARADENİZ, CEYDA, and OKUR, ARZU

Subjects
Cancer Research, Gastrointestinal Stromal Tumors, Antineoplastic Agents, Risk Assessment, Piperazines, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Biomarkers, Tumor, Humans, Child, Protein Kinase Inhibitors, neoplasms, General Medicine, Protein-Tyrosine Kinases, digestive system diseases, Proto-Oncogene Proteins c-kit, Pyrimidines, Treatment Outcome, Oncology, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Benzamides, Colonic Neoplasms, Imatinib Mesylate, Female, Tomography, X-Ray Computed
Abstract

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the alimentary tract rarely observed in children. The treatment of choice for GIST is surgical resection. Although the prognosis of GISTs with low malignant potential is excellent, high-malignant- potential GISTs have a high rate of recurrence. Prognostic factors such as tumor size, mitotic rate and presence of metastases may provide an indication for adjuvant imatinib mesylate (IM) treatment. Here we present a young patient with a large GIST with high-risk features who is in complete remission after surgical excision and adjuvant IM treatment. This patient is the only colon-located CD117-positive case where IM was administered. The exact indications as well as the optimal dose and duration of IM need to be clarified with the contribution of new cases and the growing experience of this rare disease. © Il Pensiero Scientifico Editore.

Published
2012

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