1. Botulinum Toxin Injections for Pediatric Patients With Hereditary Spastic Paraparesis
- Author
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Dafna Domenievitz, Keren Geva-Dayan, Aviva Fattal-Valevski, and Rafat Zahalka
- Subjects
Male ,medicine.medical_specialty ,Hereditary spastic paraplegia ,Botulinum toxin a ,Muscle tone ,Activities of Daily Living ,Outcome Assessment, Health Care ,Humans ,Medicine ,Botulinum Toxins, Type A ,Child ,Muscle, Skeletal ,Retrospective Studies ,Spastic Paraplegia, Hereditary ,business.industry ,Infant ,Spastic paraparesis ,Mean age ,medicine.disease ,Botulinum toxin ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Neuromuscular Agents ,Ashworth scale ,Child, Preschool ,Anesthesia ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Female ,Neurology (clinical) ,business ,Botulinum toxin type ,medicine.drug - Abstract
Limited information is available on the use of botulinum toxin type A injections for children with hereditary spastic paraplegia. This report includes 12 children with hereditary spastic paraplegia (mean age 4.8 ± 2.5 years) who underwent 1 to 6 sessions of botulinum toxin A injections to the hamstrings, adductors and gastrocnemius muscles. Patients showed both improved muscle tone (mean 1.9 ± 0.5 vs 1.18 ± 0.33, P < .001, Ashworth Scale) and motor function (75.3 ± 11.9 vs 77.7 ± 11, P < .001, Gross Motor Function Measure). The effect lasted for a mean of 6.6 ± 3.6 months. During the study period (mean 2.8 ± 1.8 years), the preinjection Gross Motor Function Measure increased (69.2 ± 14.7 vs 78.3 ± 13.5, P = .005), whereas the Ashworth Scale remained stable, suggesting a prolonged effect of botulinum toxin A on motor function. The authors conclude that botulinum toxin A injections to lower limbs of pediatric patients with hereditary spastic paraplegia result in prolonged functional improvement despite the progressive nature of the disease.
- Published
- 2010
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