1. Outcomes after venous thromboembolism in patients with gastric cancer: Analysis of the RIETE Registry
- Author
-
Adriana Visonà, Riete Investigators, Jorge Del Toro, Ido Weinberg, Pierpaolo Di Micco, Joan Carles Sahuquillo, Iva Golemi, Alfonso Tafur, Kaushal Majmudar, Manuel Alejandro Lorente, Conxita Falga, Antonella Tufano, Manuel Monreal, Majmudar, K., Golemi, I., Tafur, A. J., Toro, J. D., Visona, A., Falga, C., Sahuquillo, J. C., Lorente, M. A., Tufano, A., Weinberg, I., Di Micco, P., and Monreal, M.
- Subjects
Registrie ,Male ,Time Factors ,Databases, Factual ,030204 cardiovascular system & hematology ,Gastroenterology ,Hemoglobins ,0302 clinical medicine ,Recurrence ,Risk Factors ,thrombosi ,Registries ,Aged, 80 and over ,education.field_of_study ,Hazard ratio ,Anemia ,Venous Thromboembolism ,Middle Aged ,Prognosis ,Thrombosis ,Venous thrombosis ,Deep vein thrombosis (DVT) ,030220 oncology & carcinogenesis ,Cohort ,pulmonary embolism (PE) ,Female ,Cardiology and Cardiovascular Medicine ,Human ,medicine.medical_specialty ,Time Factor ,Prognosi ,Population ,Hemorrhage ,Risk Assessment ,03 medical and health sciences ,Stomach Neoplasm ,Stomach Neoplasms ,Internal medicine ,deep vein thrombosis (DVT) ,medicine ,Humans ,Hemoglobin ,education ,thrombosis ,Aged ,business.industry ,gastric cancer ,Risk Factor ,Cancer ,Biomarker ,medicine.disease ,bleeding ,business ,Biomarkers - Abstract
Gastric cancer is the fifth most common malignancy worldwide. Venous thromboembolism is an independent predictor of death among patients with gastric cancer. We aimed to describe the factors associated with mortality, thrombosis recurrence, and bleeding complications in patients with gastric cancer who develop venous thromboembolism. We included 612 patients with gastric cancer and venous thromboembolism in the Registro Informatizado de la Enfermedad TromboEmbólica (RIETE) registry from 2001 to 2018. We used Cox proportional hazard ratios and a Fine–Gray model to define factors associated with outcomes. The overall mortality at 6 months was 44.4%. Factors associated with increased 6-month mortality included immobility (HR 1.8, 95% CI 1.3–2.4; p < 0.001), anemia (HR 1.4, 95% CI 1.1–1.8; p < 0.02), and leukocytosis (HR 1.8, 95% CI 1.4–2.3; p < 0.001). Recurrent thrombosis occurred in 6.5% of patients and major bleeding complications in 8.5% of the cohort. Male sex was the main factor associated with thrombosis recurrence (HR 2.1, 95% CI 1.1–4.0; p < 0.02) and hemoglobin below 10 g/dL (HR 1.6, 95% CI 1.05–2.50; p = 0.03) the main factor associated with bleeding. In conclusion, patients with gastric cancer who develop venous thrombosis have a very high likelihood of death. Low hemoglobin in this population is associated with poor outcomes.
- Published
- 2020