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1. Etravirine combined with antiretrovirals other than darunavir/ritonavir for HIV-1-infected, treatment-experienced adults: Week 48 results of a phase IV trial

Author

Magda Opsomer, Rodica Silaghi, Ludo Lavreys, Herta Crauwels, As’ad E. Bhorat, Simon Vanveggel, Lotke Tambuyzer, Eduardo Arathoon, and Ben Van Baelen

Subjects
safety, 0301 basic medicine, Oncology, medicine.medical_specialty, Darunavir+Ritonavir, efficacy, Etravirine, Phase IV Trial, Treatment experienced, 03 medical and health sciences, Pharmacokinetics, Internal medicine, medicine, Darunavir, lcsh:R5-920, business.industry, virus diseases, General Medicine, 030112 virology, virology, Tolerability, Original Article, Ritonavir, lcsh:Medicine (General), business, pharmacokinetics, medicine.drug
Abstract

Objective: VIOLIN (TMC125IFD3002; NCT01422330) evaluated the safety, tolerability, and pharmacokinetics of etravirine with antiretrovirals other than darunavir/ritonavir in HIV-1-infected patients. Methods: In a 48-week, phase IV, single-arm, multicenter study, patients on prior antiretroviral therapy (⩾8 weeks) who needed to change regimen for virologic failure (viral load ⩾ 500 copies/mL) or simplification/adverse events (viral load

Published
2017

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