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1. The effects of antacids on the absorption of enteric-coated phenylbutazone (butacote).

Author

Downie WW, Lowe JR, and Pickup ME

Subjects
Adult, Aluminum Hydroxide administration & dosage, Aluminum Hydroxide blood, Antacids administration & dosage, Antacids blood, Female, Humans, Magnesium administration & dosage, Magnesium blood, Magnesium pharmacology, Male, Phenylbutazone administration & dosage, Phenylbutazone blood, Silicic Acid administration & dosage, Silicic Acid blood, Silicic Acid pharmacology, Tablets, Enteric-Coated, Antacids pharmacology, Phenylbutazone metabolism
Abstract

Phenylbutazone bioavailability from an enteric-coated formulation (Butacote) has been studied in normal volunteers following ingestion of a single 200 mg dose with water, aluminium hydroxide and magnesium trisilicate. No significant alteration in bioavailability of phenylbutazone from Butacote was noted in the presence of the antacids.

Published
1977

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