1. Life-threatening antineutrophil cytoplasmic antibody-associated vasculitis after influenza A H1N1 infection requiring veno-venous extracorporeal membrane oxygenation.
- Author
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Frantzeskaki, Frantzeska G., Dimopoulos, Stavros, Konstantonis, Dimitrios, Katsibri, Pelagia, Kostopanagiotou, Kostantinos, Theodorakopoulou, Maria, Diakaki, Chrysi, Dougenis, Dimitrios, Boumpas, Dimitrios, Karabinis, Andreas, Armaganidis, Apostolos, and Tsangaris, Iraklis
- Subjects
VASCULITIS treatment ,EXTRACORPOREAL membrane oxygenation ,HEMORRHAGE ,LUNG diseases ,VASCULITIS ,H1N1 influenza ,INFLUENZA A virus, H1N1 subtype ,ANTINEUTROPHIL cytoplasmic antibodies ,DISEASE complications - Abstract
Introduction: Antineutrophil cytoplasmic autoantibody-associated vasculitis is an immune-mediated necrotizing vasculitis, affecting small- and medium-sized vessels. Case report: A 22-year-old female patient with free medical history presented with life-threatening pulmonary hemorrhage due to antineutrophil cytoplasmic autoantibody-associated vasculitis, temporarily associated with influenza A H1N1 infection. Due to rapidly worsening respiratory failure, despite conventional management, veno-venous peripheral extracorporeal membrane oxygenation was initiated and continued for 26 days, with subsequent renal replacement therapy. Discussion: We present a case of severe antineutrophil cytoplasmic autoantibody-associated pulmonary vasculitis, managed with veno-venous extracorporeal membrane oxygenation at the initial phase. Despite the significant challenges raised with the use of extracorporeal membrane oxygenation in pulmonary hemorrhage cases, extracorporeal membrane oxygenation may have a significant impact on outcome in this setting, by providing adequate time for a successful immunosuppressive treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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