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Your search keyword '"RAPPAPORT, S. C."' showing total 6 results
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6 results on '"RAPPAPORT, S. C."'

1. The effect of 5,5'-diphenylhydantoin on the metabolism of 17 beta-estradiol by rat oral mucosa.

Author

Vittek J, Munnangi PR, Gordon GG, Rappaport SC, and Southren AL

Subjects
Animals, Gingiva drug effects, Gingiva metabolism, Male, Mouth Mucosa drug effects, Rats, Rats, Inbred Strains, Time Factors, Estradiol metabolism, Mouth Mucosa metabolism, Phenytoin pharmacology
Abstract

Systemic pretreatment of rats with 5,5'-diphenylhydantoin (DPH) or its addition into an in vitro assay increases microsomal hydroxylation of 17 beta-estradiol. This increase depends on the concentration of DPH in the microsomal cell compartment.

Published
1982
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2. Cellular regulation of the metabolism of androgens in rat oral mucosa. II. Product activation of 17 beta-hydroxysteroid oxidoreductase enzyme system.

Author

Vittek J, Gordon GG, Rappaport SC, and Southren AL

Subjects
Androstenedione pharmacology, Animals, Binding Sites, Cytosol enzymology, Enzyme Activation drug effects, Male, Mouth Mucosa cytology, Rats, Testosterone pharmacology, 17-Hydroxysteroid Dehydrogenases metabolism, Androstenedione metabolism, Mouth Mucosa enzymology, Testosterone metabolism
Abstract

Product activation of 17beta-hydroxysteroid oxidoreductase for testosterone and androstenedione was established using the enzyme preparation from rat oral mucosa. It is suggested that this activation could be due to the conformational changes of the enzyme.

Published
1979
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3. Cellular regulation of the metabolism of androgens in rat oral mucosa. III. Activation of delta 4-3-ketosteroid-5alpha-A ring reductase enzyme system by 5,5-diphenylhydantoin.

Author

Vittek J, Gordon GG, Rappaport SC, and Southren AL

Subjects
Animals, Cytosol enzymology, Enzyme Activation drug effects, Kinetics, Male, Mouth Mucosa cytology, Rats, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase metabolism, Mouth Mucosa enzymology, Oxidoreductases metabolism, Phenytoin pharmacology, Testosterone metabolism
Abstract

Systemic pretreatment of rats with diphenylhydantoin (DPH) or its addition into an in vitro assay increases 5alpha-reduction of testosterone by the oral mucosa. Enzyme kinetic studies showed that DPH binds to the enzyme and probably activates it by an allosteric mechanism.

Published
1979
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4. Effect of progestins on androgen delta4-3-ketosteroid-5alpha-A-ring reductase system in rat oral mucosa.

Author

Vittek J, Altman K, Rappaport SC, Gordon GG, Hagedorn J, and Southren AL

Subjects
Androstenedione analogs & derivatives, Animals, Kinetics, Microsomes enzymology, Mouth Mucosa metabolism, NAD metabolism, NADP metabolism, Rats, Testosterone analogs & derivatives, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase metabolism, Androstenedione metabolism, Medroxyprogesterone pharmacology, Mouth Mucosa enzymology, Oxidoreductases metabolism
Abstract

Rat oral mucosa microsomal delta4-3-ketosteroid-5alpha-A-ring reductase enzyme system, reducing testosterone and 4-androstenedione, was found to be inducible by systemic administration of medroxyprogesterone acetate (MPA). MPA, when used in a mixture with testosterone and/or 4-androstenedione in vitro, acted as a competitive inhibitor of the reduction of these substrates.

Published
1978
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5. Metabolism of androgens by human periodontal ligament.

Author

Vittek J, Rappaport SC, Gordon GG, Hagedoorn J, and Southren AL

Subjects
Adolescent, Adult, Androstanols metabolism, Androsterone metabolism, Dihydrotestosterone metabolism, Etiocholanolone analogs & derivatives, Etiocholanolone metabolism, Female, Humans, Male, Middle Aged, Periodontal Ligament enzymology, Androstenedione metabolism, Periodontal Ligament metabolism, Periodontitis metabolism, Testosterone metabolism
Published
1982
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6. Cellular regulation of the metabolism of androgens in rat oral mucosa: I. Effect of medroxyprogesterone acetate (MPA) on the soluble supernatant (cytosol) activating microsomal delta4-3-ketosteroid-5alpha-reductase and 17beta-hydroxysteroid oxidoreductase enzyme systems.

Author

Vittek J, Rappaport SC, Gordon GG, and Southren AL

Subjects
Androgens metabolism, Animals, Enzyme Activation drug effects, Mouth Mucosa cytology, Progestins pharmacology, Rats, Stimulation, Chemical, 17-Hydroxysteroid Dehydrogenases metabolism, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase metabolism, Cytosol physiology, Medroxyprogesterone pharmacology, Microsomes enzymology, Mouth Mucosa enzymology, Oxidoreductases metabolism, Testosterone metabolism
Abstract

Soluble supernatant (cytosol) of rat oral mucosa was found to contain a factor accelerating the activity of microsomal delta4-3-ketosteroid-5alpha-reductase and 17beta-hydroxysteroid oxidoreductase enzymes metabolizing testosterone. Systemic administration of medroxyprogesterone acetate further increased this cytosolic activity.

Published
1978
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