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32 results on '"Zuccalà, A."'

1. Targeting Stem Cells with Hyperthermia: Translational Relevance in Cancer Patients

Author

Patrick Pessaux, Girolamo Ranieri, Michele Ammendola, Cosmo Damiano Gadaleta, Valeria Zuccalà, Maria Luposella, Giuseppe Navarra, Giuseppe Currò, Lucia Stella Curto, and Riccardo Memeo

Subjects
Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Cancer stem cell, Neoplasms, Internal medicine, Animals, Humans, Medicine, Hyperthermia, 030212 general & internal medicine, Heat-Shock Proteins, Cancer, Chemotherapy, Cancer stem cells, business.industry, Hyperthermia, Induced, General Medicine, Therapy, medicine.disease, Clinical trial, Radiation therapy, Tumor progression, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Stem cell, business, Carcinogenesis
Abstract

Background: Tumor recurrences or metastases remain a major hurdle in improving overall cancer survival. In anticancer therapy, some patients inevitably develop chemo-/radiotherapy resistance at some point. Cancer stem cells are the driving force of tumorigenesis, recurrences, and metastases, contributing also to the failure of some cancer treatments. Summary: Emergent evidence suggests that stem cell diseases are at the base of human cancers, and tumor progression and chemo-/radiotherapy resistance may be dependent on just a small subpopulation of cancer stem cells. Hyperthermia can be a strong cancer treatment, especially when combined with radio- or chemotherapy. It is a relatively safe therapy, may kill or weaken tumor cells, and significantly increases the effectiveness of other treatments. However, these mechanisms remain largely unknown. A literature search was performed using PubMed including cited English publications. The search was last conducted in December 2019. Search phrases included “stem cells,” “hyperthermia,” “cancer,” and “therapy.” Abstracts, letters, editorials, and expert opinions were not considered for the drafting of the study. Key Message: Our goal was to focus on and to summarize different biological features of cancer stem cells and new therapeutic approaches using hyperthermia and its potential translation to human clinical trials.

Published
2020

3. Physical Performance and Clinical Outcomes in Dialysis Patients: A Secondary Analysis of the Excite Trial

Author

Piergiorgio Messa, Giorgio Fuiano, Rossella Baggetta, Renato Rapanà, Giovanni Tripepi, Francesco Rapisarda, Antonio Barillà, Filippo Aucella, Fabrizio Fabrizi, Pasquale Fatuzzo, Luigi Lombardi, Luciano De Paola, Fabio Manfredini, Davide Bolignano, Adamasco Cupisti, Silvio Bertoli, Graziella D'Arrigo, Daniele Ciurlino, Lisa Rocca-Rey, Chiara Summaria, Alessandro Zuccalà, Pietro Castellino, Carmine Zoccali, Luigi Catizone, Graziella Bonanno, Yuri Battaglia, Claudia Torino, Gaetano Lucisano, Stefania Rastelli, and Francesca Mallamaci

Subjects
Male, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_treatment, Physical exercise, dialysis, Randomized trial, PHYSICAL PERFORMANCE, mortality, hospitalization, Walking, lcsh:RC870-923, Physical performance, law.invention, Randomized controlled trial, law, Chronic kidney disease, Clinical outcomes, Secondary analysis, Six-minute walking test, lcsh:Dermatology, General Medicine, Middle Aged, Exercise Therapy, Treatment Outcome, Nephrology, Female, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Endpoint Determination, MEDLINE, Motor Activity, Dialysis patients, Renal Dialysis, medicine, Humans, Survival analysis, Dialysis, Aged, business.industry, Walking test, lcsh:RL1-803, lcsh:Diseases of the genitourinary system. Urology, Survival Analysis, lcsh:RC666-701, Exercise Test, Physical therapy, Kidney Failure, Chronic, Physical performance, Six-minute walking test, Chronic kidney disease, Dialysis, Clinical outcomes, business
Abstract

Background/Aims: Scarce physical activity predicts shorter survival in dialysis patients. However, the relationship between physical (motor) fitness and clinical outcomes has never been tested in these patients. Methods: We tested the predictive power of an established metric of motor fitness, the Six-Minute Walking Test (6MWT), for death, cardiovascular events and hospitalization in 296 dialysis patients who took part in the trial EXCITE (ClinicalTrials.gov Identifier: NCT01255969). Results: During follow up 69 patients died, 90 had fatal and non-fatal cardiovascular events, 159 were hospitalized and 182 patients had the composite outcome. In multivariate Cox models - including the study allocation arm and classical and non-classical risk factors - an increase of 20 walked metres during the 6MWT was associated to a 6% reduction of the risk for the composite end-point (P=0.001) and a similar relationship existed between the 6MWT, mortality (PConclusions: Poor physical performance predicts a high risk of mortality, cardiovascular events and hospitalizations in dialysis patients. Future studies, including phase-2 EXCITE, will assess whether improving motor fitness may translate into better clinical outcomes in this high risk population.

Published
2014

4. Recovery Time after Hemodialysis Is Inversely Associated with the Ultrafiltration Rate

Author

Bossola, Maurizio, primary, Di Stasio, Enrico, additional, Monteburini, Tania, additional, Parodi, Emanuele, additional, Ippoliti, Fabio, additional, Cenerelli, Stefano, additional, Santarelli, Stefano, additional, Nebiolo, Pier Eugenio, additional, Sirolli, Vittorio, additional, Bonomini, Mario, additional, Antocicco, Manuela, additional, Zuccalà, Giuseppe, additional, and Laudisio, Alice, additional

Published
2018
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5. The Personal Computer in a Dialysis Unit

Author

Pietro Zucchelli, Antonio Santoro, E. Degli Esposti, A. Galigani, Marco Spongano, Alessandro Zuccalà, and Alessandra Sturani

Subjects
medicine.medical_specialty, business.industry, Personal computer, Dialysis unit, medicine, Medical emergency, Intensive care medicine, business, medicine.disease
Published
2015

6. Ischemic Renal Failure

Author

Pietro Zucchelli and Alessandro Zuccalà

Subjects
Nephrology, medicine.medical_specialty, business.industry, Incidence (epidemiology), Internal medicine, Emergency medicine, MEDLINE, Cardiology, Medicine, Autopsy, business
Published
2015

10. Ischemic Nephropathy in the Elderly

Author

Pietro Zucchelli and Alessandro Zuccalà

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Incidence (epidemiology), MEDLINE, medicine.disease, Balloon, Text mining, Embolism, Hypertension complications, Internal medicine, Angioplasty, medicine, Cardiology, Ischemic Nephropathy, business
Published
2015

12. Hypertension in IgA Glomerulonephritis

Author

C. Chiarini, R. Gaggi, Alessandro Zuccalà, Antonio Santoro, E. Degli Esposti, Alessandra Sturani, and Pietro Zucchelli

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Glomerulonephritis, Glomerulonephritis iga, Creatinine blood, business, medicine.disease, Gastroenterology
Published
2015

13. Pathophysiology and Management of Hypertension in Hemodialysis Patients

Author

Pietro Zucchelli, Alessandra Sturani, Alessandro Zuccalà, Antonio Santoro, and E. Degli Esposti

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine, Hemodialysis, Intensive care medicine, business, Pathophysiology
Published
2015

16. The Natural History of Reflux Nephropathy

Author

Pietro Zucchelli, R. Gaggi, and Alessandro Zuccalà

Subjects
Natural history, Reflux nephropathy, medicine.medical_specialty, Pathology, business.industry, medicine, medicine.disease, business, Intensive care medicine
Published
2015

17. Detection of Renal Artery Stenosis by Means of Captopril Renography with 99mTc-DTPA

Author

F Marchetta, Levorato M, Maurizio Dondi, C Corbelli, M. Mirelli, A Stella, P Zagni, Alessandro Zuccalà, R. Gaggi, and F. Losinno

Subjects
education.field_of_study, medicine.medical_specialty, Kidney, medicine.diagnostic_test, business.industry, Population, Urology, Renal Artery Obstruction, Radioisotope renography, Captopril, urologic and male genital diseases, Renal artery stenosis, medicine.disease, Surgery, Stenosis, medicine.anatomical_structure, medicine.artery, medicine, Renal artery, education, business, medicine.drug
Abstract

The aim of this study was to evaluate the role of captopril renography in detecting renal artery stenosis in a population of patients referred for renal scan for hypertension, azatenica and/or reduced kidney size

Published
2015

19. Primary Hypertension as a Cause of End-Stage Renal Failure

Author

Pietro Zucchelli, R. Gaggi, and Alessandro Zuccalà

Subjects
medicine.medical_specialty, Blood pressure, business.industry, End stage renal failure, Internal medicine, Hypertension complications, Cardiology, MEDLINE, Medicine, business
Published
2015

20. Relationship between Plasma Noradrenaline and Blood Pressure in Uremia

Author

Alessandra Sturani, Antonio Santoro, E. Degli Esposti, Pietro Zucchelli, Alessandro Zuccalà, R. Gaggi, and C. Chiarini

Subjects
medicine.medical_specialty, Plasma noradrenaline, Endocrinology, Blood pressure, business.industry, Internal medicine, medicine, medicine.disease, business, Uremia
Published
2015

21. Riassunti in Italiano

Author

Yaniv Sherer, Keita Fujikawa, Lora Bregman, Sanjeev Parshad, S. Kurokawa, Ulrich Grein, A. Zuccalà, Joseph Mishal, Vinod Nargund, Jeremy G. Noble, J. Lloreta, F. Peris, Iqbal Singh, R. Hofmann, Anil Bhan, Narihito Seki, Toshiro Migita, F. Sciobica, I. Geramoutsos, David Cranston, T. Becker, O. Muraishi, Octavian Leibovici, G. Barbalias, D. Eland, I. Schwetlick, Z. Varga, C. De Dominicis, Shoichiro Mukai, A. Tokue, Griff J. Fellows, P. Perimenis, O. Bielsa, Niels-Peter Buchholz, A. Heidenreich, Andreas Giese, P.M. Deka, M. İlteriş Tekin, G. Di Crosta, A. Gelabert-Mas, Hideo Takeuchi, Boris Yoffe, S. Serrano, S.P. Yadav, Kohshiro Maeda, Hiroya Oka, Yoshiyuki Matsui, K. Suzuki, Hann-Chorng Kuo, Ghulam Nabi, Hakan Ozkardes, F. Iori, M.S. Ansari, A. Athanasopoulos, A.K. Hemal, Fatih Boyvat, Walter Ludwig Strohmaier, Daniel London, M. Ciccariello, Levent Peskircioglu, T.P. Rajeev, Nobuo Ogata, A. Hegele, Ayako Gamachi, N. van Kaam, Shigeki Fukuzawa, Wolfgang W. Meyer, D. van den Ouden, O. Arango, and B. Arora

Subjects
business.industry, Urology, Medicine, business, Humanities
Published
2001

22. Effect of Age on Left Atrial Function in Patients with Coronary Artery Disease

Author

Giuseppe Zuccalà, Roberto Bernabei, Alberto Cocchi, P. U. Carbonin, and Fabrizia Lattanzio

Subjects
Aging, medicine.medical_specialty, Coronary Disease, Doppler echocardiography, Ventricular Function, Left, Coronary artery disease, Wall stress, Left atrial, Internal medicine, medicine, Humans, Pharmacology (medical), In patient, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Echocardiography, Doppler, Cardiology, Dilation (morphology), Atrial Function, Left, Left ventricular diastolic dysfunction, Cardiology and Cardiovascular Medicine, Ventricular filling, business, Blood Flow Velocity
Abstract

Both coronary artery disease and aging produce a similar pattern of left ventricular diastolic dysfunction with increased left atrial (LA) activity. We studied the Doppler left ventricular filling pattern in 75 patients (age 40-91 years) with coronary artery disease. A linear correlation with age was found for iso-volumic relaxation time, peak atrial flow velocity, and atrial filling fraction; an independent effect of age and LA size on these parameters could be demonstrated. As an overall correlation was found between LA diameter and atrial function indexes, we compared such parameters among four subgroups with increasing LA size; the LA function indexes were increased with minor degrees of LA dilation and decreased with further LA expansion. As LA dilation was found only in older patients, it can be supposed that the combined effects of aging and disease on LA wall stress accounted for LA dilation and dysfunction in these subjects.

Published
1994

23. Mast Cell Positivity to Tryptase Correlates with Metastatic Lymph Nodes in Gastrointestinal Cancer Patients Treated Surgically

Author

Ammendola, Michele, primary, Sacco, Rosario, additional, Donato, Giuseppe, additional, Zuccalà, Valeria, additional, Russo, Emilio, additional, Luposella, Maria, additional, Vescio, Giuseppina, additional, Rizzuto, Antonia, additional, Patruno, Rosa, additional, De Sarro, Giovambattista, additional, Montemurro, Severino, additional, Sammarco, Giuseppe, additional, and Ranieri, Girolamo, additional

Published
2013
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24. Calendario dei Congressi

Author

Keita Fujikawa, A.K. Hemal, Shigeki Fukuzawa, Wolfgang W. Meyer, D. van den Ouden, M.S. Ansari, Lora Bregman, Hann-Chorng Kuo, A. Hegele, S. Serrano, Ghulam Nabi, Ulrich Grein, Boris Yoffe, F. Peris, Nobuo Ogata, Sanjeev Parshad, Narihito Seki, Joseph Mishal, Vinod Nargund, Yoshiyuki Matsui, S. Kurokawa, A. Gelabert-Mas, F. Sciobica, B. Arora, A. Zuccalà, O. Arango, O. Bielsa, O. Muraishi, G. Di Crosta, Toshiro Migita, M. İlteriş Tekin, David Cranston, Yaniv Sherer, Griff J. Fellows, P. Perimenis, T. Becker, M. Ciccariello, A. Tokue, R. Hofmann, C. De Dominicis, A. Athanasopoulos, Z. Varga, Iqbal Singh, I. Geramoutsos, Daniel London, I. Schwetlick, J. Lloreta, Octavian Leibovici, Andreas Giese, G. Barbalias, D. Eland, S.P. Yadav, A. Heidenreich, Levent Peskircioglu, Hideo Takeuchi, Ayako Gamachi, Hakan Ozkardes, Anil Bhan, N. van Kaam, T.P. Rajeev, Hiroya Oka, Jeremy G. Noble, Walter Ludwig Strohmaier, Fatih Boyvat, Shoichiro Mukai, Niels-Peter Buchholz, Kohshiro Maeda, F. Iori, P.M. Deka, and K. Suzuki

Subjects
business.industry, Urology, Medicine, business, Humanities
Published
2001

27. Contents, Vol. 21, 1978

Author

Degli Esposti, Grace Connor, Luciano Barajas, Pietro Zucchelli, Catizone L, Cleaves M. Bennett, Edwina A. Brown, Shinichi Hosokawa, Kazuyuki Daizyo, Joseph Levi, Alessandro Zuccalà, David Edelbaum, G.M. Aber, Hanna Bessler, Juichi Kawamura, Fredric O. Finkelstein, Rabbe R. Lindstrom, Osamu Yoshida, Stanley A. Brosman, Alan S. Kliger, Meir Djaldetti, M. Fusaroli, and Ligabue A

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1978

28. Renal Scintigraphy versus Renal Vein Renin Activity for Identifying and Treating Renovascular Hypertension

Author

Piero Pavlica, Franco Vecchi, Nino Monetti, Pietro Zucchelli, Antonio Santoro, Alessandra Sturani, Ezio Degli Esposti, C. Chiarini, Alessandro Zuccalà, and Franco Losinno

Subjects
Adult, Male, medicine.medical_specialty, Hypertension, Renal, Adolescent, Population, Urology, Renal scintigraphy, Plasma renin activity, Renal Veins, Renovascular hypertension, Diagnosis, Differential, Renin, medicine, Humans, Child, Radionuclide Imaging, education, Aged, education.field_of_study, Arterial stenosis, business.industry, Urography, Intravenous pyelography, Middle Aged, Prognosis, medicine.disease, Collateral circulation, Surgery, Hypertension, Renovascular, Female, Renal vein, business
Abstract

This paper compares renal scintigraphy (RS) with renal vein renin activity (RVRA), intravenous pyelography (IVP), and peripheral plasma renin activity (pPRA) in a population of hypertensive subjects with suspect renovascular hypertension (RVH), of whom 30 underwent surgery, in order to evaluate (a) screening ability of RS for RVH, and (b) surgical prognosis of RS for RVH. RS agreed with arteriographic findings of arterial stenosis in 91% of patients and proved more sensitive as a screening test than IVP and pPRA. The false-negative rate of RS was 9% and the false-positive rate was 10%. In the patients who underwent surgery RS was positive in 89% and RVRA in 85% of those who benefited from surgery. In this series false-negatives for RS occurred only in the presence of extensive collateral circulation, where RVRA also gave the same result. In patients who had been operated on, the sensitivity and specificity of RS, compared to RVRA, were very high. Our work supports the view that RS is a good screening test in RVH; moreover, it seems to be as accurate as RVRA as a surgical prognostic method for curable RVH.

Published
1982

32. Subject Index, Vol. 21, 1978

Author

Meir Djaldetti, Pietro Zucchelli, Kazuyuki Daizyo, Alessandro Zuccalà, Stanley A. Brosman, G.M. Aber, Hanna Bessler, Joseph Levi, Cleaves M. Bennett, Edwina A. Brown, Juichi Kawamura, M. Fusaroli, Ligabue A, Osamu Yoshida, Fredric O. Finkelstein, Alan S. Kliger, Catizone L, Degli Esposti, David Edelbaum, Rabbe R. Lindstrom, Grace Connor, Luciano Barajas, and Shinichi Hosokawa

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1978

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