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5 results on '"Yoshiki, Ishii"'

1. Concurrence of Sarcoidosis and Lung Cancer

Author

Yoshiki Ishii, Satoshi Kitamura, and Hideaki Yamasawa

Subjects
Pulmonary and Respiratory Medicine, Systemic disease, Pathology, medicine.medical_specialty, Mediastinal lymphadenopathy, business.industry, Respiratory disease, medicine.disease, Pathophysiology, Metastasis, medicine, Carcinoma, Sarcoidosis, Lung cancer, business
Abstract

Although sarcoidosis and lung cancer are both frequently encountered conditions, their simultaneous occurrence in the same patient is unusual. In this report, we describe 4 cases of their concurrence and discuss the possible pathogenic mechanisms of their concurrent appearance. In particular, in 2 of the cases, both diseases had coexisted for a long period (more than 6 and 4 years, respectively), showing a surprisingly slow growth of cancers. Although the chest computed tomography showed hilar and mediastinal lymphadenopathy, the histopathological findings of the excised lymph nodes of both cases revealed no metastasis. The causal relationship between sarcoidosis and lung cancer remains uncertain, but cases such as these may be helpful in elucidating its precise nature.

Published
2000
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2. Effects of Inhalation of Nitroglycerin on Hypoxic Pulmonary Vasoconstriction

Author

Satoshi Kitamura, Masashi Bando, Yoshiki Ishii, and Shoji Ohno

Subjects
Male, Pulmonary and Respiratory Medicine, Pulmonary Circulation, Vascular smooth muscle, Hypertension, Pulmonary, Vasodilator Agents, Blood Pressure, Pulmonary Artery, Pharmacology, Nitric oxide, Nitroglycerin, chemistry.chemical_compound, Dogs, Hypoxic pulmonary vasoconstriction, Administration, Inhalation, medicine, Animals, Cardiac Output, Hypoxia, Infusions, Intravenous, Analysis of Variance, Inhalation, biology, business.industry, Respiratory disease, Fissipedia, Hemodynamics, medicine.disease, biology.organism_classification, Pulmonary hypertension, Pathophysiology, Disease Models, Animal, chemistry, Vasoconstriction, Anesthesia, Vascular Resistance, business
Abstract

Recent studies suggest that nitric oxide (NO) may play an important role in the pathophysiology of pulmonary hypertension. Nitroglycerin is metabolized to NO, which is a potent vascular smooth muscle relaxant. The aim of the present study was to compare the effects of inhaled and infused nitroglycerin on pulmonary hemodynamics and gas exchange in anesthetized, artificially ventilated dogs. Nitroglycerin was administrated either by inhalation or by infusion. Systemic blood pressure (SBP), pulmonary arterial pressure (PAP), and pulmonary capillary wedge pressure (PCWP) were measured, and cardiac output was estimated by an electromagnetic flowmeter. Blood gas measurements were performed during hypoxic gas exposure (FiO2; 0.1) with a continuous inhalation or infusion of nitroglycerin (1, 2.5 µg/kg/min). Inhaled (n = 4) and infused (n = 4) nitroglycerin (1 µg/kg/min) did not produce any detectable effects on the hemodynamics. Inhaled nitroglycerin (2.5 µg/kg/min) reduced SBP, PAP and calculated pulmonary vascular resistance (PVR) in all dogs. Cardiac output did not change. In addition, inhaled nitroglycerin increased PaO2. In contrast, the continuous infusion of nitroglycerin (2.5 µg/kg/min) did not change in PAP, whereas infused nitroglycerin decreased the mean SBP. Infused nitroglycerin did not alter cardiac output and calculated PVR. A decreased PaO2 was noted in 2 dogs on nitroglycerin infusion. These findings indicate that inhaled nitroglycerin effects the pulmonary circulation relatively more than infused nitroglycerin, which tends to have more of a general effect on the systemic circulation. The effects of inhaled nitroglycerin may thus be comparable to the effects of NO inhalation.

Published
1998
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3. A Wind of Change

Author

S. Tsipra, E. Begliomini, José Morera, Özden Günel, Satoshi Kitamura, Giuliano Ciappi, Simonetta Baldi, S. Loukides, Ziya Kumcuoğlu, Manabu Inuzuka, Kunter Perim, A. Breitenbücher, Roser Gomez, K. Christou, P. Panagou, Yoshiki Ishii, E. Fité, Ramon Coll, Emel Çelikten, Kazuhiko Suzuki, Hiroshi Tanaka, Salvatore Valente, Murat Sungur, Giorgio Fumagalli, L. Bernardi, O. Appenzeller, Juan Ruiz, Turgay Celikel, C.T. Bolliger, Hüdaver Alper, Basel H. Herzog, C. Passino, Marino De Rosa, Vienna F. Kummer, Ümit Bayol, Timur Köse, J.M. Antó, Takashi Shibusa, Berrin Ceyhan, Giuseppe Maria Corbo, Shoji Ohno, Francesco Pistelli, A. Efthimiou, Çiǧdem Ataizi Çelikel, Pilar Romero, Ezio M. Ferdeghini, Ufuk Çağırıcı, José Antonio Fiz, Semra Bilaceroglu, Giovanni Viegi, Khalid Rauf, I. Mankovskaya, B. Hamos, Masashi Bando, M. Solèr, Annalisa Carlucci, N. Kalogeropoulos, R. Gayer, D. Giachino, K.I. Gourgoulianis, C. Mordasini, Peter V. Dicpinigaitis, Takuya Fujishima, Emine Osma, Berrin Baǧcı Ceyhan, Yoshie Shibuya, J.M. Alsina, T. Serebrovskaya, I. Karaban, Despina Rizopoulou, Shosaku Abe, José Izquierdo, J. Morera, and M.C. Hernandez

Subjects
Pulmonary and Respiratory Medicine, business.industry, Ecology, Environmental resource management, Medicine, business
Published
1998
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4. Thank you, Professor Heinrich Herzog

Author

Özden Günel, Simonetta Baldi, José Antonio Fiz, B. Hamos, I. Karaban, Semra Bilaceroglu, Despina Rizopoulou, Ramon Coll, Shosaku Abe, E. Fité, Ziya Kumcuoğlu, Roser Gomez, Pilar Romero, Kazuhiko Suzuki, Giuseppe Maria Corbo, Marino De Rosa, Berrin Baǧcı Ceyhan, Ufuk Çağırıcı, S. Loukides, Giuliano Ciappi, Vienna F. Kummer, Shoji Ohno, Turgay Celikel, K. Christou, Annalisa Carlucci, C. Passino, C.T. Bolliger, Basel H. Herzog, Satoshi Kitamura, Çiǧdem Ataizi Çelikel, Berrin Ceyhan, R. Gayer, José Izquierdo, J. Morera, A. Breitenbücher, K.I. Gourgoulianis, Juan Ruiz, M. Solèr, N. Kalogeropoulos, Masashi Bando, Francesco Pistelli, T. Serebrovskaya, Manabu Inuzuka, J.M. Antó, Peter V. Dicpinigaitis, Takuya Fujishima, I. Mankovskaya, Murat Sungur, Ümit Bayol, Timur Köse, Giovanni Viegi, Khalid Rauf, D. Giachino, Kunter Perim, Yoshiki Ishii, P. Panagou, Emine Osma, J.M. Alsina, Salvatore Valente, Hüdaver Alper, S. Tsipra, E. Begliomini, José Morera, O. Appenzeller, Emel Çelikten, Hiroshi Tanaka, A. Efthimiou, Yoshie Shibuya, C. Mordasini, Takashi Shibusa, Ezio M. Ferdeghini, M.C. Hernandez, Giorgio Fumagalli, and L. Bernardi

Subjects
Pulmonary and Respiratory Medicine, business.industry, Medicine, Environmental ethics, business, Classics
Published
1998
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5. Farewell and Many Thanks

Author

C. Passino, Özden Günel, M. Solèr, N. Kalogeropoulos, D. Giachino, S. Loukides, Simonetta Baldi, Emine Osma, J.M. Alsina, Murat Sungur, Marino De Rosa, E. Fité, T. Serebrovskaya, S. Tsipra, Turgay Celikel, Vienna F. Kummer, Ufuk Çağırıcı, Çiǧdem Ataizi Çelikel, Berrin Ceyhan, E. Begliomini, José Morera, I. Karaban, José Antonio Fiz, Hiroshi Tanaka, Despina Rizopoulou, I. Mankovskaya, Francesco Pistelli, Salvatore Valente, Masashi Bando, Hüdaver Alper, Pilar Romero, Shosaku Abe, Giovanni Viegi, Khalid Rauf, Satoshi Kitamura, C.T. Bolliger, Giuseppe Maria Corbo, Shoji Ohno, Yoshiki Ishii, Semra Bilaceroglu, Juan Ruiz, Roser Gomez, Berrin Baǧcı Ceyhan, Ramon Coll, Manabu Inuzuka, A. Breitenbücher, P. Panagou, B. Hamos, Giuliano Ciappi, J.M. Antó, Emel Çelikten, José Izquierdo, J. Morera, Annalisa Carlucci, R. Gayer, O. Appenzeller, Giorgio Fumagalli, L. Bernardi, K.I. Gourgoulianis, Peter V. Dicpinigaitis, Takuya Fujishima, Kazuhiko Suzuki, Basel H. Herzog, Yoshie Shibuya, Ziya Kumcuoğlu, K. Christou, A. Efthimiou, Ezio M. Ferdeghini, Kunter Perim, Takashi Shibusa, M.C. Hernandez, Ümit Bayol, Timur Köse, and C. Mordasini

Subjects
Pulmonary and Respiratory Medicine, business.industry, Art history, Medicine, business
Published
1998
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