1. Molecular Cytogenetic Analysis of a Gliosarcoma with Osseous Metaplasia
- Author
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Torstein R. Meling, Petter Brandal, Hanne Sofie S Dahlback, Ludmila Gorunova, David Scheie, Francesca Micci, and Sverre Heim
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Gliosarcoma ,Biology ,Lateral Ventricles ,Genetics ,medicine ,Chromosomes, Human ,Humans ,Fibrosarcoma ,Molecular Biology ,In Situ Hybridization, Fluorescence ,Genetics (clinical) ,Aged ,Comparative Genomic Hybridization ,Metaplasia ,Brain Neoplasms ,Mesenchymal stem cell ,Karyotype ,medicine.disease ,Karyotyping ,%22">Fish ,Osseous metaplasia ,Glioblastoma - Abstract
Gliosarcoma, a rare glioblastoma variant, is composed of a glial and a mesenchymal component. Though the mesenchymal portion most commonly resembles a fibrosarcoma, other differentiation patterns have been observed. We present the first genomic characterisation (karyotyping followed by FISH and array comparative genomic hybridisation analysis) of a gliosarcoma with osseous metaplasia. In addition to chromosomal changes often found in gliomas (+7,–10,–13, and –22), the tumour cells also harboured a hitherto unknown t(3;21)(q13∼21;q21∼22).
- Published
- 2011