1. Assessment of Baseline Clinical Predictive Factors of Response to Cetuximab-Irinotecan in Patients with Irinotecan-Refractory Metastatic Colorectal Cancer
- Author
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Mohamed Hebbar, Pierre Michel, Patricia Maes, Renata Péreira, Emilia Rad, Olivier Bouché, Thierry Conroy, Laurent Gasnault, Antoine Adenis, Frédéric Di Fiore, Nathalie Deligny, Jean-Paul Joly, Charles Fournier, Peggy Fournier, and Claire Giraud
- Subjects
Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,Cetuximab ,Salvage therapy ,Adenocarcinoma ,Antibodies, Monoclonal, Humanized ,Irinotecan ,Metastasis ,Immunoenzyme Techniques ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,heterocyclic compounds ,neoplasms ,Survival rate ,Aged ,Retrospective Studies ,Aged, 80 and over ,Salvage Therapy ,Chemotherapy ,business.industry ,Antibodies, Monoclonal ,Cancer ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,digestive system diseases ,Surgery ,ErbB Receptors ,Survival Rate ,stomatognathic diseases ,Treatment Outcome ,Drug Resistance, Neoplasm ,Camptothecin ,Female ,Colorectal Neoplasms ,business ,therapeutics ,medicine.drug - Abstract
Objective: To identify easily available predictive factors of response to cetuximab-irinotecan in patients with irinotecan-refractory metastatic colorectal cancer. Methods: Retrospective analysis of patients treated with cetuximab (400 mg/m2 in week 1, 250 mg/m2 in subsequent weeks) plus irinotecan (180 mg/m2 every 2 weeks). We assessed demographic data, prior response to chemotherapy, number of metastatic sites, disease and metastatic disease durations, irinotecan-free interval and tumoral immunohistochemical epidermal growth factor receptor status. Results: We analyzed 311 patients. Objective response rate under cetuximab-irinotecan was 26%. In univariate analysis, prior response to irinotecan, presence of only 1 metastatic site, disease duration, metastatic disease duration and irinotecan-free interval equal or above median (24, 18 and 1.8 months, respectively) were predictive of response to cetuximab-irinotecan. Multivariate analysis confirmed independent predictive value of prior response to irinotecan, number of metastatic sites and disease duration. Conclusion: Prior response to irinotecan, number of metastatic sites and disease duration may contribute to better select patients suitable for cetuximab-irinotecan therapy.
- Published
- 2007
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