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1. The Potential of a Stroke Registry Using Diagnosis Procedure Combination Data from All Hospitals in a Japanese Prefecture

Author

Shinichi Omama, Kozo Tanno, Yoshihiro Inoue, Kuniaki Ogasawara, Takeshi Fukuda, Yuetsu Oikawa, Toshiyuki Onoda, Masaki Ohsawa, and Kiyomi Sakata

Subjects
Male, Stroke, Cerebrovascular Disorders, Japan, Neurology, Humans, Female, Registries, Neurology (clinical), Cardiology and Cardiovascular Medicine, Hospitals, Cerebral Hemorrhage
Abstract

Objectives: In Japan, many hospitals have joined the diagnosis procedure combination/per-diem payment system (DPC/PDPS), which provides unified information about inpatients. DPC data are digitized, and the number of participating hospitals has increased recently. Herein, we evaluated the potential of a stroke registry constructed using these unified DPC data from all hospitals in the Iwate Prefecture, Japan. Methods: The proportion of cerebrovascular disease (CVD) cases registered by DPC-participating hospitals was calculated and compared with all registered cases in the Iwate Stroke Registry in 2008–2017. The cases were categorized based on sex, age-groups, stroke subtypes, and first-ever onset or recurrence onset. Based on the registered cases in the stroke registry, the accuracy of the CVD cases extracted by the disease name from DPC data of a typical core hospital and a typical noncore hospital was evaluated. Results: Of the 71 hospitals with 9,992 beds in the Iwate Prefecture in 2018, 50 hospitals with 8,316 beds participated in the DPC system. The proportion of registered cases from participating hospitals was 95.2% (44,779/47,018) for all stroke types (95.6% men and 94.9% women), 94.3% for cerebral infarction, 97.0% for intracerebral hemorrhage, and 98.7% for subarachnoid hemorrhage, whereas it was 95.7% for first-ever onset and 94.1% for recurrent onset. The proportion of registered cases decreased with increasing patient age. Attending doctors and researchers registered 486 and 41 CVD cases from the core and noncore hospitals, respectively, whereas 455 and 46 CVD cases were extracted from the DPC data of these hospitals, respectively. This yielded 86.6% sensitivity, 99.3% specificity, 92.5% positive predictive value, and 98.7% negative predictive value for the core hospital; these values were 92.7%, 98.6%, 82.6%, and 99.5%, respectively, for the noncore hospital. Discussion/Conclusions: The stroke registry constructed using DPC data from all hospitals of Iwate Prefecture appears to be adequately complete and accurate.

Published
2022
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2. Theophylline at Therapeutic Concentrations Inhibits NF-κB Activation in Human Lung Mast Cells

Author

Stephen T. Holgate, Hironori Sagara, Takeshi Fukuda, Martin K. Church, Mayumi Ota, Naomi Chibana, and Sohei Makino

Subjects
Allergy, business.industry, medicine.drug_class, Immunology, Respiratory disease, Inflammation, General Medicine, medicine.disease, Mast cell, respiratory tract diseases, medicine.anatomical_structure, Mechanism of action, Bronchodilator, Immunology and Allergy, Medicine, Cytokine secretion, Theophylline, medicine.symptom, business, medicine.drug
Abstract

Inflammation of the airways is a cardinal feature of asthma. It has recently been recognized that mast cells may contribute to this process by cytokine secretion. Activation of a number of transcription factors, such as NF-ĸB, results in the de novo synthesis of a wide spectrum of cytokines including TNFα, IL-8 and GM-CSF. We have assessed the activation of NF-ĸB by exposure of purified lung mast cells to TNFα (5 ng/ml), SCF (10 ng/ml) and anti-IgE (1 µg/ml). Mast cells were identified by cytospin immunocytochemistry using the antitryptase antibody AA-1 and activated NF-ĸB visualized by the antibody 2c7 (Upjohn) which recognizes a site revealed only on its dissociation from I-ĸB. In addition, the effects of theophylline and other modulatory drugs have been examined on NF-ĸB activation and consequential cytokine secretion. Results show that TNFα increased the percentage of cells staining positive for activated NF-ĸB from 8.4 ± 4.8 to 63 ± 4.5 within 15 min. Anti-IgE caused a slow increase from 4.3 ± 0.4 to 45.4 ± 13.3% at 4 h. Theophylline at 20 µg/ml decreased TNFα and anti-IgE induced NF-ĸB activation by 37.3 ± 2.1 and 25.3 ± 1.3%, respectively. Secretion of TNFα, IL-8 and GM-CSF was also inhibited by 20 µg/ml theophylline. The suppression of NF-ĸB activation indicates that theophylline, in addition to its bronchodilator actions, has anti-inflammatory activity which is likely to be pertinent to the treatment of bronchial asthma.

Published
2001
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3. Suppressive Effects of SP-A on Ionomycin-Induced IL-8 Production and Release by Eosinophils

Author

Takashi Ueda, Syunichi Kinjyo, Gang Cheng, Hirokazu Nakajima, Takeshi Fukuda, Akiko Nakajima, and Shinji Motojima

Subjects
Pulmonary Surfactant-Associated Proteins, Proteolipids, Immunology, Inflammation, In Vitro Techniques, Allergic inflammation, chemistry.chemical_compound, Immune system, Pulmonary surfactant, medicine, Humans, Immunology and Allergy, Interleukin 8, Lung, Dose-Response Relationship, Drug, Pulmonary Surfactant-Associated Protein A, biology, Ionomycin, Interleukin-8, Antibodies, Monoclonal, Pulmonary Surfactants, General Medicine, Asthma, Surfactant protein A, Eosinophils, chemistry, biology.protein, Antibody, medicine.symptom
Abstract

Recent studies have demonstrated that pulmonary surfactant protein (SP)-A plays a potential role in modifying inflammation and immune function. To see whether SP-A could modify IL-8 production and release by eosinophils stimulated with ionomycin, SP-A purified from surfactant recovered from patients with alveolar proteinosis was added to eosinophils isolated by the negative-selection method with immunomagnetic beads, and cultured for 24 h. The concentrations of IL-8 in the cell-free supernatants and cell lysates were then measured by ELISA. SP-A attenuated the production of IL-8 by eosinophils in a concentration-dependent manner. SP-A also attenuated the release of IL-8 from the eosinophils. The addition of SP-A antibody (PE10) reversed these effects of SP-A completely. These data suggest that SP-A may have the potential to modify allergic inflammation by inhibiting the release and production of IL-8 by eosinophils.

Published
1998
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4. Serum Levels of Eosinophil Cationic Protein and IL-5 in Patients with Asthma without Systemic Corticosteroids

Author

Shinji Motojima, Takashi Koseki, Takeshi Fukuda, Kinji Tateishi, and Sohei Makino

Subjects
Adult, Male, Eosinophil cationic protein, business.industry, Immunology, Blood Proteins, General Medicine, Eosinophil Granule Proteins, Middle Aged, medicine.disease, Asthma, Ribonucleases, Monitoring, Immunologic, Forced Expiratory Volume, medicine, Humans, Immunology and Allergy, Female, In patient, Interleukin-5, business, Interleukin 5, Aged
Abstract

We measured the serum levels of eosinophil cationic protein (ECP) and interleukin-5 (IL-5) in 39 patients with asthma (symptomatic 12, asymtomatic 27) without systemic corticosteroids and 49 healthy subjects. There were significant differences in serum levels in both ECP and IL-5 between symptomatic and asymptomatic asthma, and healthy subjects. A significant positive correlation was found between serum levels of ECP and IL-5. No significant correlation was found between %FEV1 and serum level of ECP or IL-5, however, when the analysis was restricted to patients of less than 60 years of age, the correlations were significant. These results suggest that IL-5 is one of the factors that activate eosinophils even in peripheral blood, and that measurement of serum levels of ECP and IL-5 is useful for in vitro monitoring of asthma.

Published
1997
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5. Production of IL-8 and Release of Eosinophil-Derived Neurotoxin by Normal Peripheral Blood Eosinophils

Author

Sohei Makino, Hirokazu Nakajima, Hirohito Kita, Gerald J. Gleich, and Takeshi Fukuda

Subjects
medicine.medical_specialty, Neurotoxins, Immunology, Eosinophil-derived neurotoxin, Eosinophil-Derived Neurotoxin, Biology, chemistry.chemical_compound, Ribonucleases, Internal medicine, medicine, Humans, Immunology and Allergy, Eosinophil degranulation, Secretion, RNA, Messenger, Eosinophil cationic protein, Dose-Response Relationship, Drug, Ionomycin, Interleukin-8, General Medicine, Eosinophil, Molecular biology, Eosinophils, Reverse transcription polymerase chain reaction, Endocrinology, medicine.anatomical_structure, chemistry, Immunoglobulin A, Secretory, Cytokine secretion
Abstract

To study the regulation of IL-8 production and release of eosinophil-derived neurotoxin (EDN) by normal blood eosinophils, we isolated eosinophils from healthy individuals and stimulated them with immobilized secretory IgA with or without exogenous IL-5 for 3, 12, and 24 h, and with different concentrations of ionomycin for 24 h. Eosinophils cultured with secretory IgA for 3 and 12 h showed strong expression of mRNA for IL-8 by reverse transcription polymerase chain reaction. Exogenous IL-5 enhanced mRNA for IL-8 expression by eosinophils after 24 h of incubation. IL-8 secretion increased in a time-dependent manner throughout the 24 h of observation; in contrast, EDN release reached a plateau value after 12 h. Furthermore, at least 2 microM ionomycin was necessary for induction of IL-8 secretion, whereas 0.5 microM induced detectable EDN release by eosinophils. These results suggest that the mechanism of eosinophil degranulation may be different from those of cytokine secretion.

Published
1997
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6. Comparison of Platelet-Activating Factor Receptor mRNA Levels in Peripheral Blood Eosinophils from Normal Subjects and Atopic Asthmatic Patients

Author

Hironori Sagara, Seishi Kishimoto, Keizo Waku, Takeshi Fukuda, Takayuki Sugiura, Takao Shimizu, Sohei Makino, Wataru Shimadzu, and Takashi Izumi

Subjects
Adult, Transcription, Genetic, Immunology, Receptors, Cell Surface, Platelet Membrane Glycoproteins, Platelet membrane glycoprotein, Polymerase Chain Reaction, Receptors, G-Protein-Coupled, Allergic inflammation, Pathogenesis, chemistry.chemical_compound, medicine, Humans, Immunology and Allergy, RNA, Messenger, Platelet Activating Factor, Receptor, Asthma, Platelet-activating factor, business.industry, General Medicine, Middle Aged, respiratory system, Eosinophil, medicine.disease, Eosinophils, medicine.anatomical_structure, chemistry, lipids (amino acids, peptides, and proteins), Platelet-activating factor receptor, business
Abstract

Platelet-activating factor (PAF) modulates the functions of eosinophils, which play an important role in allergic inflammation, through a specific receptor(s) expressed on the cell surface. We compared expression levels of mRNA for the PAF receptor (PAF-R) in peripheral blood eosinophils from atopic asthmatic patients with those from normal healthy subjects using a relative quantification method based on the reverse transcription-polymerase chain reaction (RT-PCR). We found that the levels of PAF-R mRNA in eosinophils from the patients were significantly higher than those in normal subjects. These results suggest that the increased expression of PAF-R in eosinophils may be relevant to the pathogenesis of atopic asthma.

Published
1997
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7. A Monoclonal Antibody against Very Late Activation Antigen-4 Inhibits Eosinophil Accumulation and Late Asthmatic Response in a Guinea Pig Model of Asthma

Author

Hironori Sagara, Hironori Matsuda, Takeshi Fukuda, Hideo Yagita, Ko Okumura, Sohei Makino, Naruhito Wada, and Chisei Ra

Subjects
Male, Integrins, Guinea Pigs, Immunoblotting, Immunology, Receptors, Lymphocyte Homing, Fluorescent Antibody Technique, Vascular Cell Adhesion Molecule-1, Cross Reactions, Integrin alpha4beta1, Basophil, Guinea pig, Eosinophil migration, Antigen, Cell Movement, Cell Adhesion, Animals, Immunology and Allergy, Medicine, Eosinophilia, Eosinophil cationic protein, biology, business.industry, Antibodies, Monoclonal, General Medicine, respiratory system, Eosinophil, Flow Cytometry, Precipitin Tests, Asthma, respiratory tract diseases, Eosinophils, Disease Models, Animal, Ovalbumin, medicine.anatomical_structure, biology.protein, Endothelium, Vascular, medicine.symptom, business
Abstract

Preferential eosinophil accumulation is a characteristic of airway inflammation in asthma. Although little is known about its mechanism, recent in vitro observations suggest that the very late activation antigen-4 (VLA-4, CD49d/CD29) and vascular cell adhesion molecule-1 (VCAM-1) adhesion pathway may be involved in specific eosinophil migration. To test this hypothesis, we studied the effect of an anti-VLA-4 monoclonal antibody (mAb) on the airway eosinophilia in a guinea pig model of asthma. Guinea pigs were sensitized by repeated inhalation of ovalbumin. After a single inhalation challenge, the animals showed a striking airway eosinophilia and late asthmatic response (LAR). In contrast, when guinea pigs were pretreated intravenously at 2 h before antigen challenge with a rat antimouse VLA-4 mAb, PS2/3, cross-reacting with guinea pig eosinophils and lymphocytes, eosinophil, basophil and lymphocyte infiltration in the tracheal wall was significantly inhibited as well as LAR in a dose-dependent manner. These results suggest that VLA-4 plays a critical role in antigen-induced airway eosinophilia and LAR.

Published
1997
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8. Contents, Vol. 111, Supplement 1, 1996

Author

Matsunobu Suko, Masayuki Ando, Wataru Shimazu, Nobuo Tsuruoka, Hisaho Takahashi, Yoko Nishizaki, Takashi Izumi, Goro Yamada, Hironobu Sugita, Takenori Okada, Nobuo Yamada, Osamu Urayama, Hironori Sagara, Hidemi Nakagawa, Tomokazu Kakazu, Hisao Tomioka, Takao Shimizu, Shoichi Sakamoto, Masaharu Kawabata, Akio Mori, Kazuko Fujita, Mineharu Sugimoto, Takeshi Fukuda, Nobukazu Tomichi, Keiko Umemiya, Kenji Saito, Tomoko Yoshida, Chisei Ra, Hirokazu Okudaira, Tatsuo Kawashima, Shigenori Nakajima, Tadashi Tezuka, Kunihiko Tamaki, Sakumi Shinohara, Ryutaro Matsumura, Keizo Waku, Toshiro Shibuya, Kyoko Yamashiro, Takayuki Sugiura, Hiroshi Saito, Junichi Chihara, Kazuhiko Oki, Haruto Hirano, Hidekazu Yamada, Ikkou Higashimoto, Yoshinori Kawabata, Masaru Kagami, Kiyoshi Takatsu, Yuichi Nakamura, Mitsuomi Hirashima, Osamu Kaminuma, Shinpei Furusawa, Seishi Kishimoto, Tatsuo Yudate, Jiang Li, Moritaka Suga, Ko Okumura, Akira Tsuda, Yukako Arakawa, Toshiyuki Koike, Kenichi Takeuchi, Tsutomu Sakuma, Atsushi Saito, Masashi Shiiba, Hideo Enokihara, Sohei Makino, Takashi Takaiwa, Motoshi Wakugawa, Kenichi Ochiai, Kazusige Futai, Katsuo Ikezawa, Mitsuhiro Osame, Hideo Kikkawa, Nobuyoshi Takahashi, Terumasa Miyamoto, Naoki Saita, Masayoshi Nishimoto, Satoshi Takaki, Tohru Yamanaka, Ryo Izutani, Sapaldiz Team, Hirotsugu Kohrogi, Ryuichiro Maeda, and Masaharu Matsukura

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1996
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9. Sialyl Lewis X Analog Inhibits Eosinophil Accumulation and Late Asthmatic Response in a Guinea-Pig Model of Asthma

Author

Hironori Sagara, Sakumi Shinohara, Ko Okumura, Chisei Ra, Takenori Okada, Sohei Makino, and Takeshi Fukuda

Subjects
Male, Time Factors, Guinea Pigs, Immunology, Anti-Inflammatory Agents, Oligosaccharides, Inflammation, Cross Reactions, Umbilical vein, Guinea pig, chemistry.chemical_compound, Cell Adhesion, medicine, Animals, Humans, Immunology and Allergy, Eosinophilia, Sialyl Lewis X Antigen, Cells, Cultured, biology, Inhalation, business.industry, General Medicine, respiratory system, Eosinophil, Asthma, respiratory tract diseases, Eosinophils, Chemotaxis, Leukocyte, Ovalbumin, medicine.anatomical_structure, Sialyl-Lewis X, chemistry, biology.protein, Endothelium, Vascular, medicine.symptom, business
Abstract

Preferential eosinophil accumulation is characteristic of airway inflammation in asthma. Although little is known about its mechanism, the effect of a sialyl Lewis X analog on airway eosinophilia was examined in a guinea-pig model of asthma. Guinea-pigs were sensitized by repeated inhalation of ovalbumin. After a single inhalation challenge, the animals showed striking airway eosinophilia and a late asthmatic response. In contrast, when guinea-pigs were pretreated intravenously with sialyl Lewis X analog (LX 0104) 1 h before antigen challenge, both eosinophil infiltration in the tracheal wall and the late asthmatic response were significantly inhibited in a dose-dependent manner. In a further in vitro study, LX 0104 significantly suppressed the adhesion of human and guinea-pig eosinophils to human umbilical vein endothelial cells activated with interleukin-1 beta. These results suggest that LX 0104 plays a critical role in antigen-induced airway eosinophilia and the late asthmatic response.

Published
1996
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10. Contents, Vol. 108, Supplement 1, 1995

Author

Masafumi Tsujimoto, Mineharu Sugimoto, Shimpei Furusawa, Hideo Shishido, Koichi Hirai, Atsushi Saito, Kaneshige Yoshida, Kenji Saitou, Kazuhiko Oki, Ken Ohta, Akihiko Terada, Shigeru Takafuji, Mitsuomi Hirashima, Makino S, Kensuke Watanabe, Munetada Haruyama, Haruhito Sugiyama, Masakuni Aoyagi, Nobuo Tsuruoka, Toshiaki Takaishi, Yoshinori Kawabata, Hitoshi Kamiya, Takao Fujisawa, Yutaka Morita, Tadashi Kasahara, Teiji Iwamoto, Mariko Iida, Kenichi Takeuchi, Takayuki Ohtoshi, Hideo Enokihara, Matsunobu Suko, Masayuki Ando, Hironobu Sugita, Hisaho Takahashi, Junichi Chihara, Shigenori Nakajima, Clemens A. Dahinden, Takeshi Fukuda, Takeru Ishikawa, Takahiro Yamamoto, Ken-ichi Manaka, Koji lto, Go Matsuzaki, Yuuichi Nakamura, Yuichi Takahashi, Ikko Higashimoto, Seigou Hirayama, Naoki Saita, Toshiyuki Koike, Shoichi Sakamoto, Misato Miyamasu, Kiyoshi Takatsu, Ikkou Higashimoto, Nobukazu Tomichi, Kenji Tadokoro, Jun Atsuta, Yukako Arakawa, Minoru Sakurai, Dai Kurachi, Yosinori Kawabata, Kanji Watanabe, Hironari Arimura, Masafumi Arima, Tomokazu Kakazu, Kosei Iguchi, Hirokazu Okudaira, and Koji Ito

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1995
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11. Role of Platelet-Activating Factor in the Release of Neutrophil and Eosinophil Chemotactic Attractants from Cultured Guinea-Pig Tracheal Epithelial Cells

Author

Ken-ichi Manaka, Masafumi Arima, Takeshi Fukuda, and Makino S

Subjects
Male, Neutrophils, Neutrophile, Guinea Pigs, Immunology, Receptors, Cell Surface, Platelet Membrane Glycoproteins, Biology, Piperazines, Receptors, G-Protein-Coupled, chemistry.chemical_compound, medicine, Animals, Immunology and Allergy, Platelet Activating Factor, Chemotactic Factors, Platelet-activating factor, Granulocyte-Macrophage Colony-Stimulating Factor, Epithelial Cells, Chemotaxis, General Medicine, respiratory system, Eosinophil, In vitro, Epithelium, Eosinophils, Trachea, Thiazoles, Granulocyte macrophage colony-stimulating factor, medicine.anatomical_structure, chemistry, Cell culture, Thiazolidines, medicine.drug
Abstract

Platelet-activating factor (PAF) has been implicated in the pathogenesis of allergic disease, particularly bronchial asthma, by recruitment and activation of inflammatory cells. In an effort to further elucidate this function of PAF, guinea-pig tracheal mucosa was cultured in the presence of PAF in vitro, and culture supernatants were injected intradermally into normal guinea-pigs. After 6 h, recruitment of the inflammatory cells in the tissue was evaluated as a marker of chemotactic activity. Neutrophil and eosinophil recruitment increased significantly 1 h after PAF stimulation, the latter more than the former. After fractionation of the culture supernatant using molecular sieve filters, the fraction of 10-30 kDa showed greater chemotactic activity than the fractions of below 10 kDA or greater than 30 kDA. This activity was inhibited in a dose-dependent manner (over about 1-100 mg/ml) by treatment with anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibody. These results suggest that PAF induces the release of chemotactic factors for neutrophils and eosinophils from guinea-pig tracheal epithelial cells, and one of these factors may be GM-CSF.

Published
1995
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12. GM-CSF and Eosinophil Chemotactic Factors in an Acute Lymphoblastic Leukemia Patient with Eosinophilia

Author

Kenji Saito, Shigeki Nagashima, Shinpei Furusawa, Takeshi Fukuda, Yasutsugu Fukushima, Hideo Enokihara, Hideo Shishido, Hajime Yamato, S. Tsunogake, and Ruka Kita

Subjects
Adult, Pathology, medicine.medical_specialty, Chemotactic Factors, Eosinophil, medicine.medical_treatment, Cell, Granulocyte, Cerebrospinal fluid, Acute lymphocytic leukemia, Eosinophilia, medicine, Humans, business.industry, Granulocyte-Macrophage Colony-Stimulating Factor, Hematology, General Medicine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Eosinophil, medicine.disease, medicine.anatomical_structure, Cytokine, Granulocyte macrophage colony-stimulating factor, Immunology, Female, medicine.symptom, business, medicine.drug
Abstract

We describe a patient with common acute lymphoblastic leukemia associated with blood and cerebrospinal fluid (CSF) eosinophilia. Serum obtained at onset and conditioned medium prepared from T cells obtained at remission stimulated with interleukin-2 contained eosinophil colony stimulating activity (Eo-CSA), which was confirmed to be predominantly GM-CSF. Leukemic cell conditioned medium and serum obtained at remission contained no Eo-CSA. The CSF contained increased eosinophil chemotactic activity, however, this factor was not identified.

Published
1993
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13. Development of a Guinea Pig Model of Chronic Asthma with Markedly Thickened Airway Walls: Two Studies Using This Animal Model

Author

Hironori Sagara, Takako Hiyama, Masao Toda, Takeshi Fukuda, Yasuhiro Nakano, and Minoru Yoshida

Subjects
Bronchus, Pathology, medicine.medical_specialty, Allergy, business.industry, Immunology, Respiratory disease, General Medicine, medicine.disease, Pathogenesis, Guinea pig, medicine.anatomical_structure, medicine, Immunology and Allergy, Airway, business, Asthma, Respiratory tract
Published
2001
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14. Contents, Vol. 94, 1991

Author

Graham S. LeGros, Hiroshi Yamakawa, K. Takatsu, Ratko Djukanovic, P.G. Holt, J. Bujanowski-Weber, P. Oehme, S. Bianchj, William Roche, I. Knöller, G. Delespesse, Toru Ando, Reinhold Penner, D. Macchia, R. Djukanovic, George W. Ward, Thomas Bieber, T. Furitsu, Makoto Dohi, Susan M. MacDonald, Martin D. Chapman, F. Chavarria, R. Robert Schellenberg, Michiko Haida, Makoto Nogami, John R. Brashler, J. Brom, Pascal Chanez, A. Ciccarelli, T.D. Whalley, M.J. Carmona, E. Saito, Mamoru Ito, H. Behrendt, W. Zachgo, Gabriele Zwadlo-Klarwasser, Philip J. Thompson, Sylvia Miescher, N.P. Siemensma, A. de Paulis, G. Schultze-Werninghaus, J.-P. Kinet, B.D. Gomperts, Takeo Juji, Ikuo Akutsu, Richard J. Simpson, S. Wilson, T.H. Lee, Suhad El-Lati, Bernhard Przybilla, J. Oliver, Sesha Reddigari, Monique Vogel, Koki Takahashi, Thomas Iff, L. Mugnai, E. Neher, Nathalie Paul-Eugène, Ph. Lassalle, Takeshi Fukuda, Dean D. Metcalfe, V. Lagente, C.E. O’Neil, Go Matsuzaki, C. McMenamin, Jordan N. Fink, G. Burow, Ch. Lemmermann, Ch. Schweiger, H. Wagner, K. Kurihara, D.R. Springall, Karin Pettenburger, A. Capron, H.Y.A. Lau, R. Wahl, G.J. Gleich, K. Rother, Shigeru Takafuji, W.R. Roche, Kurt Blaser, F. Gambassi, A. Pistelli, M. Bubak, Andrew F. Walls, Jeffrey M. Drazen, S.J. Lane, Johann-Christian Virchow, Akio Mori, J.M. Polak, Dietrich Kraft, Hans L. Spiegelberg, L. Lipponer, Friederike von zur Mühlen, R. zur Strassen, Rihoux Jean-Pierre, Susanne Spitzauer, Werner J. Pichler, Karen Britten, M. Schon-Hegrad, Barbara K. Stout, John Wilson, Hirokazu Okudaira, Otto Scheiner, Mitsuko Kondo, Akira Ishii, Richard Sporik, Daniel Weinreich, M. Keating, W. Dorsch, Manel Jordana, Ch.H. Heusser, Ingrid Enander, Massimo Triggiani, T. Ishizaka, Colin J. Sanderson, Dieter Vieluf, Stephanie A. Shore, J. Anrather, S. Terrados, Claus Bachert, Rosa M. Ten, E.W. Rauterberg, E. Masini, H. Rumpold, Jean Yves Lacoste, T.H.W. Lillie, K. Ohno, Alison M. Campbell, E. Gutierrez, F.L. Pearce, Stephan C. Bischoff, R. Suau, Miguel Blanca, P.H. Howarth, P.K. Jeffery, Robert L. Barker, E. Perez, M. Pfenning, Marshall Plaut, Piotr Kuna, T. Abe, H. Rotermund, Michael A. Lett-Brown, Herbert G. Johnson, Thomas Brunner, C. Ra, U. Ganzer, N. Hyslop, Kazuhiko Akiyoshi, Alain L. de Weck, J. Bews, A. Hartnell, J. Dry, K. Nosbüsch, Rafeul Alam, G. Le Gros, V. Brinkmann, Jacqueline M. Langdon, B. Thomas, P. Heap, Corinne Petit-Frère, A.G. Fernández, Wolfgang Schmutzler, Gianni Marone, Matsunobu Suko, R.W. Gristwood, D. Kraft, G.M. Walsh, A.G. Palma-Carlos, B. Bradley, N.S. Sakaguchi, J.M. Vega, O.-H. Wilhelms, R. Wiewrodt, A. Brini, Stephen R. Durham, M. Lupini, M.A. Reed, Thierry Maisonnet, A. Witzel, Peter J. Barnes, Ch. Brander, Lawrence M. Lichtenstein, A. Koffer, Y. Delneste, Laura Palma-Carlos, Jennifer Cairns, T. Brunnee, Elliott Homer, Diana J. Quint, F. Bettens, Monique Capron, Sohei Makino, Luanda Beck, T. Imai, Takayuki Ohtoshi, A. Akasawa, Lore Koller, Yoji Iikura, Naohiro Watanabe, Ahuva Nissim, J.W. Coleman, A. Ohgimi, D. Befus, J.R. Wilkinson, H. Küster, T. Katsunuma, Ch. Ebner, K.J. Turner, M.P. Piccinni, F. Ledermann, Michael Breitenbach, Bradley J. Undem, A.B. Kay, John E. Salvaggio, Carvalho de Sousa, S.T. Holgate, B. Girn, P. Berga, S. Bent, Gerald J. Gleich, Arnold S. Kirshenbaum, P.B. Boulos, Yoshitaka Ino, M. Breitenbach, R. Rathsack, May Azzawi, Sun Ying, Philippe Godard, J.H. Widdicombe, Rudolf Valenta, Christopher Corrigan, S. Romagnani, D.M. Kemeny, Bernard Dugas, Samuel B. Lehrer, Y. Churcher, John Gordon, C. Brom, F. Leynadier, Gert Kunkel, Gerard Cox, B.F. Weber, D. Diaz-Sanchez, Shinji Motojima, J.W. Wilson, Pieter L.B. Bruijnzeel, P.F. Mannaioni, K. Britten, Allen P. Kaplan, Yutaka Morita, K. Ishida, Erika Jensen-Jarolim, Jack Gauldie, Fiona R. Lake, S. Raspanti, Andrew Grant, R. Fadel, S. Dunnette, Jean Bousquet, Ivan Aebischer, Thomas A.E. Platts-Mills, T. Wyss, Richard D. O’Connor, Larry D. Ward, A.G. Morris, Clemens A. Dahinden, Toshifumi Yuuki, P. Parronchi, Hiroyuki Mochizuki, Gail M. McNutt, D.C. Reason, Martin Krieger, Lawrence E. Gelber, Naoki Inagaki, E. Kilchherr, Elisabeth Boichot, Qiu Gang, F. Gabl, Alec H. Sehon, J.V. Collins, Shiro Kasuya, J. Blomgren, Bernadette Pignol, Motohiro Ebisawa, N. Sakaguchi, Jacalyn H. Pierce, U. Blank, Fu-Tong Liu, Robert A. Seder, R. Hilger, Richard P. Bransford, M. Linssen, Jörg Kleine-Tebbe, P.D. Pare, Kazuhiko Yamamoto, Jean Michel Mencia-Huerta, Michael K. Bach, Pierre Braquet, J. Salvaggio, Reuben J.M. Falkoff, R. Merget, J. Hards, B.J. Holt, D. Strickland, P.E.R. Tatham, A.B. Tonnel, H. Saito, François-B. Michel, K. Akimoto, Jerry Dolovich, Brian M. Greenlee, Carl G. A. Persson, Anne Kagey-Sobotka, Tim R. Mosmann, Zelig Eshhar, N. Wallen, Maria Baeza, A.J. Wardlaw, Peter H. Howarth, Robin N. Poston, W. König, R.C. Benyon, M. Lopez, D. Mijic, E. Jarolim, William E. Paul, John P. Caulfield, B. Kunz, Milton A. Martins, Yasushi Okumura, J. Knöller, R. Ciriilo, K. Nieber, Geoffrey A. Stewart, Allen C. Myers, Zami Ben-Sasson, U. Hauser, M. G. Di Bello, Michael Duchêne, C. Baumgarten, C.J. Sanderson, Koji Ito, R. Valenta, M.-H. Jouvin, Menachem Rottem, F. Carswell, A. Miranda, K.R. Tainsh, Kimm J. Hamann, Judah A. Denburg, K. Wagner, Martin K. Church, Qutayba Hamid, O. Mejan, Johannes Ring, J. Fernandez, L. Juhlin, Kiyoshi Takatsu, Martin E. Sanders, Peter W. Heymann, C.E. Reed, P. Wentz-Murtha, Fred D. Finkelman, J. Llupiá, Helmut Rumpold, Stephen T. Holgate, Conceição B. Santos, G.M. Hänsch, W.L. Liu, Christoph Walker, M. Ricci, Ph. Gosset, E. Maggi, J. Wilson, R. Moqbel, and Beda M. Stadler

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1991
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15. Contents, Vol. 114, Supplment 1, 1997

Author

Somei Kojima, Yoshiki Miyachi, Hideo Kikkawa, Kosei Iguchi, Taishi Hata, Takao Shimizu, Wataru Shimadzu, Hirohito Kita, Akira Tsuda, Matsunobu Suko, Masayuki Ando, Georg Stingl, Norihisa Ogata, Kunio Sano, Hironori Sagara, Hajime Oyamada, Junich Chihara, Yuji Shimizu, Shinji Motojima, Mitsuomi Hirashima, Naoki Matsumoto, Hiroyuki Kobayashi, Makoto Nagata, Toshiyuki Koike, Kohei Yamauchi, Mitsuhiro Matsumoto, Tadashi Tezuka, Gen Tamura, Masao Tomonaga, Toru Horie, Hidekazu Yamada, Hirotsugu Kohrogi, Masatomo Mori, Yoshimichi Okayama, Julie B. Sedgwick, Keizo Waku, Akio Mori, Masaharu Matsukura, Hiroo Amano, Jong Yil Chai, Osamu Ishikawa, Martin K. Church, Shinpei Furusawa, Takashi Koseki, Takeshi Fukuda, Hideo Enokihara, Sohei Makino, Masaaki Honma, Osamu Kaminuma, Tohru Yamanaka, Masatsugu Kurokawa, Yumiko Kamada, Mitsuru Adachi, Hirokazu Okudaira, Hirokazu Nakajima, Takayuki Sugiura, Yuichi Nakamura, Takeshi Nara, Gerald J. Gleich, Hiroshi Sakagami, Tatsuo Yudate, Taku Kouro, Takashi Izumi, Hiromichi Noda, Masahiko Kato, Kazuaki Naito, Yuvadee Mahakunkijcharoen, Moritaka Suga, Osamu Urayama, Kunio Shirato, Yoshio Osada, Takao Fujisawa, Fumio Kokubu, Jun Atsuta, Kinji Tateishi, Akihiko Terada, Yuji Kikuchi, Leone K. Ashman, Naotomo Kanbe, Hisahiro Tokunaga, Takeru Ishikawa, Akihiro Morikawa, Masako Seki, Motohiro Kurosawa, William W. Busse, Kiyoshi Takatsu, Seishi Kishimoto, Yasushi Igarashi, Eun-Hee Shin, Yoichiro Matsushima, Hitoshi Kamiya, Naoki Saita, Stephan T. Holgate, Hiroki Hoshi, Minoru Sakurai, Minoru Takeda, Junichi Chihara, and Kenji Saito

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1997
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16. Subject Index Vol. 149, Suppl. 1, 2009

Author

Izumi Kikuchi, Matsunobu Suko, Kazufumi Katayama, Ken Ohta, Hikari Kato, Tomoko Masuda, Saori Ichikawa, Shintarou Suzuki, Hiroaki Harada, Nobutaka Kiyokawa, Shin Watanabe, Koichi Hagiwara, Yasuhiko Tabata, Susumu Nakae, Chiyako Oshikata, Kazuo Akiyama, Koichi Hirose, Taku Matsumoto, Takehito Kobayashi, Makoto Nagata, Shu Hashimoto, Kazuyuki Nakagome, Masahide Takeda, Yoshimichi Okayama, Satoshi Matsukura, Masayuki Sato, Marc E. Rothenberg, Noriaki Kobayashi, Yumiko Kamada, Yoshiaki Goi, Miho Odaka, Yasuhiro Kojima, Daisuke Endo, Mitsuru Imamura, Kazuo Ohuchi, Kouji Matsushima, Takayuki Ohtomo, Akio Mori, Takahiro Okasora, Wataru Ito, Chisei Ra, Shau-Ku Huang, Toshiro Takai, Takako Toda, Hideki Tatsumi, Shigeharu Ueki, Satoshi Nunomura, Toshio Seyama, Junichi Chihara, Maho Suzukawa, Makoto Dohi, Ryoichi Tanaka, Yuji Motoi, Hiroshi Nakajima, Koichi Yamamura, Hidefumi Wakashin, Masao Yamaguchi, Naoto Watanabe, Mitsuru Adachi, Atsuko Usami, Kenji Matsumoto, Mariko Mori, Minoru Kanazawa, Takashi Hirose, Kazuko Yamaoka, Kyoko Yamashita, Rikiya Koketsu, Yoshiyuki Yamada, Hiroshi Ohtsu, Rie Kamada, Naomi Tsurikisawa, Asae Hara, Sohei Makino, Lijun Yang, Hiroshi Saito, Motoyasu Iikura, Hiroko Takeuchi, Kazuya Suzuki, Shuhei Fukuda, Takahito Chiba, Koushi Ieki, Masutaka Furue, Mio Kawaguchi, Itsuo Iwamoto, Jang Ja Hong, Noriko Kitamura, Fumio Takaiwa, Akira Hirata, Hirohisa Saito, Tetsuya Adachi, Kenji Ishihara, Sohichi Nemoto, Masatsugu Kurokawa, Hiroshi Wada, Tetsuya Homma, Satoshi Konno, Noriyasu Hirasawa, Katsuhide Okunishi, Yotaro Takaku, Oh Sasaki, Tomomi Tanigai, Hiroyuki Kayaba, Jose A. Cancelas, Ko Okumura, Takahiro Tsuburai, Yasuhiro Gon, Shinya Kikuchi, Osamu Kaminuma, Hideoki Ogawa, Mariko Oguma, Takachika Hiroi, Kazuhiko Yamamoto, Yuri Nakamura, Takeshi Fukuda, and Hiroyuki Nagase

Subjects
Gerontology, Index (economics), business.industry, Immunology, Immunology and Allergy, Medicine, Subject (documents), General Medicine, business
Published
2009
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17. Preface

Author

Takeshi Fukuda

Subjects
Immunology, Immunology and Allergy, General Medicine
Published
2005
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18. Subject Index Vol. 122, Suppl. 1, 2000

Author

Hisao Tomioka, Takeru Ishikawa, Hidenori Arai, Itsuo Iwamoto, Hajime Oyamada, Ikuko Satoh, Kazuo Akiyama, Tomoe Kuwasaki, Kenji Ishihara, Hiroyuki Nagase, Kouji Matsushima, Fumio Kokubu, Hideaki Yamamoto, Hitoshi Arioka, Yoshikata Misaki, Koichi Hirai, Shigeru Kubota, Kohei Honda, Yoshiyuki Yamada, Takao Sugiyama, Yutaka Morita, Makoto Nagata, Atsushi Tachibana, Junichi Nakano, Satoshi Matsukura, Kenichi Ochiai, Mio Kawaguchi, Kenichi Tokuyama, Takeshi Fukuda, Motohiro Ito, Chang-hao Cui, Akihiro Morikawa, Kazuaki Tabe, Akio Mori, Hiroshi Yamamoto, Hisako Shimizu, Kotaro Kumano, Makoto Sueishi, Ruji Kawashima, Hideki Kuga, Atsuhito Nakao, Yukifumi Nawa, Hiroshi Saito, Hiroshi Kawasaki, Osamu Kaminuma, Masao Yamaguchi, M Kagami, Misato Miyamasu, Hirokazu Yamada, Yoshimi Kobayashi, Yoshio Sakamoto, Kazuo Ohuchi, Hirokazu Kimura, Hiroshi Matsuo, Mitsutaka Kadokura, Hiroyuki Kayaba, Naomi Yamashita, Yumiko Kamada, Osamu Yoshie, Mitsuru Adachi, Sayaka Jibiki, Takeshi Tomita, Kazuhiko Yamamoto, Youichi Motegi, Ken Ohta, Hideo Kikkawa, Hirohito Kita, Sohei Makino, Takuya Nakazawa, Mitsuomi Hirashima, Makoto Tajima, Masahiko Kato, Junichi Chihara, Toshiharu Nakajima, Norihiro Saito, Koji Ogawa, Jun Ohmori, Tadashi Miyasaka, and Hiroshi Nakajima

Subjects
Gerontology, Index (economics), business.industry, Immunology, Immunology and Allergy, Medicine, Subject (documents), General Medicine, business
Published
2000
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19. Biographical Sketch of Dr. Alec H. Sehon

Author

Matsunobu Suko, R.W. Gristwood, A.G. Palma-Carlos, T.H.W. Lillie, K. Ohno, R. Wiewrodt, K. Nosbüsch, Jacqueline M. Langdon, A. Brini, Zelig Eshhar, E. Kilchherr, V. Lagente, C.E. O’Neil, T. Katsunuma, Jean Michel Mencia-Huerta, M. Lopez, Michael K. Bach, D. Mijic, E. Jarolim, F.L. Pearce, E. Perez, Beda M. Stadler, Pierre Braquet, E. Saito, Mamoru Ito, H. Behrendt, N. Wallen, Maria Baeza, A.J. Wardlaw, Ch. Lemmermann, Ch. Schweiger, Bernadette Pignol, A. de Paulis, J. Salvaggio, Reuben J.M. Falkoff, J. Hards, William E. Paul, B.J. Holt, P. Berga, R. Djukanovic, Philip J. Thompson, Sylvia Miescher, N.P. Siemensma, Graham S. LeGros, Hiroshi Yamakawa, Yoshitaka Ino, M. Breitenbach, D. Strickland, K. Wagner, Martin K. Church, B. Bradley, Gert Kunkel, Gerard Cox, John P. Caulfield, Milton A. Martins, Yasushi Okumura, Daniel Weinreich, C.E. Reed, M.A. Reed, Thierry Maisonnet, Sesha Reddigari, Monique Vogel, Philippe Godard, J.H. Widdicombe, Robert A. Seder, F. Gabl, Christopher Corrigan, S. Romagnani, J.V. Collins, Jacalyn H. Pierce, O. Mejan, J. Fernandez, Fred D. Finkelman, J. Llupiá, O.-H. Wilhelms, H. Saito, François-B. Michel, A. Witzel, Jean Bousquet, Ivan Aebischer, Lawrence E. Gelber, Naoki Inagaki, Fu-Tong Liu, Thomas A.E. Platts-Mills, T. Wyss, D.M. Kemeny, Elisabeth Boichot, T. Imai, Y. Delneste, Ch. Brander, Stephanie A. Shore, John R. Brashler, Wolfgang Schmutzler, Richard P. Bransford, Fiona R. Lake, Ingrid Enander, W. Zachgo, Gabriele Zwadlo-Klarwasser, S. Terrados, Jennifer Cairns, Rosa M. Ten, R.C. Benyon, J.W. Coleman, Bernard Dugas, Samuel B. Lehrer, Y. Churcher, Shiro Kasuya, Takayuki Ohtoshi, G. Le Gros, D. Diaz-Sanchez, A.B. Tonnel, J. Brom, Pascal Chanez, J. Blomgren, John Gordon, P. Heap, M. Linssen, Jörg Kleine-Tebbe, Manel Jordana, Ch.H. Heusser, K. Akimoto, Jerry Dolovich, T. Ishizaka, Ratko Djukanovic, I. Knöller, Thomas Bieber, Peter H. Howarth, Helmut Rumpold, H. Rumpold, Motohiro Ebisawa, Jean Yves Lacoste, Gianni Marone, P.G. Holt, Pieter L.B. Bruijnzeel, Massimo Triggiani, Karen Britten, D.C. Reason, N. Sakaguchi, N.S. Sakaguchi, Ikuo Akutsu, G. Schultze-Werninghaus, R. Valenta, U. Blank, J.M. Vega, F. Leynadier, C. Ra, Bernhard Przybilla, K. Takatsu, Robin N. Poston, Larry D. Ward, P.K. Jeffery, Stephen R. Durham, J. Bujanowski-Weber, Nathalie Paul-Eugène, J. Dry, E.W. Rauterberg, B. Kunz, Christoph Walker, Richard J. Simpson, S. Wilson, V. Brinkmann, Ph. Lassalle, G. Burow, P.D. Pare, P. Oehme, Rafeul Alam, J. Knöller, R. Ciriilo, Conceição B. Santos, W. König, S. Bianchj, Allen C. Myers, K.R. Tainsh, Thomas Iff, E. Maggi, A. Miranda, T.D. Whalley, William Roche, Kimm J. Hamann, Lawrence M. Lichtenstein, Herbert G. Johnson, Kazuhiko Akiyoshi, Allen P. Kaplan, G. Delespesse, M.J. Carmona, H.Y.A. Lau, Kazuhiko Yamamoto, C. McMenamin, J. Wilson, Peter J. Barnes, Laura Palma-Carlos, A. Akasawa, G.M. Walsh, A. Capron, Toru Ando, W.R. Roche, Qiu Gang, Andrew F. Walls, Monique Capron, Sohei Makino, M. Lupini, Luanda Beck, J. Oliver, C. Baumgarten, L. Mugnai, C.J. Sanderson, Naohiro Watanabe, L. Lipponer, Alec H. Sehon, T. Furitsu, A. Ohgimi, Makoto Dohi, T. Brunnee, Elliott Homer, Diana J. Quint, A. Koffer, Friederike von zur Mühlen, R. Moqbel, Bradley J. Undem, Barbara K. Stout, Arnold S. Kirshenbaum, P.B. Boulos, Judah A. Denburg, M.-H. Jouvin, Werner J. Pichler, Shigeru Takafuji, M. Schon-Hegrad, Michael Breitenbach, G.M. Hänsch, Johannes Ring, J. Anrather, Robert L. Barker, Reinhold Penner, Otto Scheiner, L. Juhlin, Johann-Christian Virchow, Hirokazu Okudaira, E. Masini, S. Dunnette, Gerald J. Gleich, E. Gutierrez, Marshall Plaut, K. Nieber, F. Carswell, Piotr Kuna, R. Hilger, H. Küster, Clemens A. Dahinden, D. Macchia, W.L. Liu, M.P. Piccinni, Colin J. Sanderson, F. Gambassi, Jeffrey M. Drazen, Geoffrey A. Stewart, R. Wahl, G.J. Gleich, R. zur Strassen, R. Merget, M. Ricci, Menachem Rottem, John E. Salvaggio, Qutayba Hamid, Go Matsuzaki, Peter W. Heymann, Martin D. Chapman, P.E.R. Tatham, F. Chavarria, P. Wentz-Murtha, H. Wagner, S.J. Lane, Ph. Gosset, Akio Mori, K. Rother, Dietrich Kraft, Hans L. Spiegelberg, Kurt Blaser, A. Pistelli, Koki Takahashi, Kiyoshi Takatsu, D. Kraft, Martin E. Sanders, R. Suau, Stephen T. Holgate, T. Abe, Thomas Brunner, John Wilson, N. Hyslop, Alain L. de Weck, A. Hartnell, Corinne Petit-Frère, Zami Ben-Sasson, F. Bettens, Lore Koller, Yoji Iikura, U. Hauser, May Azzawi, Yutaka Morita, K. Ishida, M. G. Di Bello, Michael Duchêne, Koji Ito, Martin Krieger, D.R. Springall, Karin Pettenburger, J.M. Polak, Ahuva Nissim, Susanne Spitzauer, D. Befus, J.R. Wilkinson, Ch. Ebner, K.J. Turner, M. Bubak, F. Ledermann, Akira Ishii, Richard Sporik, M. Keating, A.B. Kay, Carvalho de Sousa, S.T. Holgate, B. Girn, S. Bent, Dieter Vieluf, Rihoux Jean-Pierre, W. Dorsch, Mitsuko Kondo, Claus Bachert, T.H. Lee, Suhad El-Lati, George W. Ward, E. Neher, R. Robert Schellenberg, Michiko Haida, Makoto Nogami, Brian M. Greenlee, Carl G. A. Persson, Anne Kagey-Sobotka, M. Pfenning, Dean D. Metcalfe, B.F. Weber, H. Rotermund, Shinji Motojima, J.W. Wilson, Tim R. Mosmann, Michael A. Lett-Brown, K. Kurihara, P.F. Mannaioni, Erika Jensen-Jarolim, Jack Gauldie, S. Raspanti, Andrew Grant, U. Ganzer, R. Fadel, R. Rathsack, Susan M. MacDonald, Toshifumi Yuuki, Sun Ying, B. Thomas, Rudolf Valenta, P. Parronchi, A. Ciccarelli, J.-P. Kinet, B.D. Gomperts, Takeo Juji, C. Brom, Hiroyuki Mochizuki, Gail M. McNutt, Alison M. Campbell, Takeshi Fukuda, K. Britten, Jordan N. Fink, J. Bews, Richard D. O’Connor, Stephan C. Bischoff, Miguel Blanca, P.H. Howarth, A.G. Morris, and A.G. Fernández

Subjects
Gerontology, media_common.quotation_subject, Immunology, Immunology and Allergy, Art history, General Medicine, Art, Biographical sketch, media_common
Published
1991
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20. Subject Index Vol. 120, Suppl. 1, 1999

Author

Ryo Atsuta, Tadashi Tezuka, Kana Ueno, Hirotsugu Kohrogi, Enno Christophers, Hitoshi Kamiya, Masaharu Matsukura, Motohiro Ito, Itsuo Iwamoto, Yoshimi Kobayashi, Kenji Ishihara, Hiroshi Wakiguchi, Norihiro Saito, Akinori Mochizuki, Hideko Kobayashi, Mitsuhiro Osame, Kazuo Ohuchi, Mitsuru Mochizuki, Hiroyuki Kayaba, Bruce S. Bochner, Kohei Honda, Hiroko Watanabe, Takao Fujisawa, Kenichi Ochiai, Kayako Hira, Hirokazu Kimura, Shoso Yamamoto, Yumiko Kamada, Toshiyuki Nishimuta, Yoshinosuke Fukuchi, Kazumoto Katagiri, Takeru Ishikawa, Tohru Yamanaka, Hideoki Ogawa, Tadanori Hashimoto, J. Suzuki, Hiroshi Matsuda, Sohei Makino, Shigenori Nakajima, Tomoe Kuwasaki, Masahiko Kato, Koichi Mitsuishi, Yutaka Hatano, Kazuo Akiyama, Kunio Sekine, A. Tsukadaira, Takeaki Nittoh, Y. Okubo, Yoshiko Kato, Susumu Takayasu, Yasushi Saito, Tetsushi Unno, S. Horie, Masahide Miyamoto, Koji Ogawa, Atsuhito Nakao, S. Takashi, Hidekazu Yamada, M. Sekiguchi, M. Isobe, T. Momose, Kenji Minoguchi, Matsunobu Suko, Masayuki Ando, Kosei Iguchi, Katsuo Ikezawa, Osamu Kaminuma, Masaharu Kawabata, Mitsuomi Hirashima, Kenji Matsumoto, Kenichi Tokuyama, Naoki Shimojo, Yoshiyuki Yamada, Hajime Oyamada, Satoshi Miike, Chisei Ra, Hirokazu Okudaira, Kiyoko Wada, Mizuko Mamura, Tatsuo Yudate, Ko Okumura, Chang-Hao Cui, Ikkou Higashimoto, Miho Omura, Takeshi Fukuda, Masahiko Aoyagi, Takanobu Kurashige, Rieko Kameda, Yoichi Kohno, Naoki Saita, Shinji Kurashimo, Youichi Motegi, Norihoro Saito, Ikuko Satoh, Hideaki Yamamoto, Atsushi Tachibana, Akiyoshi Konno, Akio Mori, Masaki Hiraguri, Takuji Shirasawa, Takafumi Uchida, Jens-M. Schröder, Susumu Tsurufuji, Makoto Nagata, Mitsuru Adachi, Hideo Kikkawa, Hirohito Kita, Yasurou Kohno, Akihiko Terada, Hisao Tomioka, Kayo Tsukahara, Hajime Suto, Akihiro Morikawa, and Junichi Chihara

Subjects
Gerontology, Index (economics), Immunology, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
1999
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21. Preface

Author

Sohei Makino, Takeru Ishikawa, and Takeshi Fukuda

Subjects
Immunology, Immunology and Allergy, General Medicine
Published
1999
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22. Preface

Author

Takeru Ishikawa, Sohei Makino, and Takeshi Fukuda

Subjects
Immunology, Immunology and Allergy, General Medicine
Published
1997
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23. Author Index / Subject Index

Author

Atsushi Saito, Satoshi Takaki, Nobuo Tsuruoka, Matsunobu Suko, Masayuki Ando, Toshiyuki Koike, Motoshi Wakugawa, Ko Okumura, Nobuo Yamada, Wataru Shimazu, Ryuichiro Maeda, Shoichi Sakamoto, Yukako Arakawa, Kenichi Takeuchi, Hisaho Takahashi, Tohru Yamanaka, Junichi Chihara, Tadashi Tezuka, Akio Mori, Mineharu Sugimoto, Kenji Saito, Hironobu Sugita, Sakumi Shinohara, Hirotsugu Kohrogi, Sapaldiz Team, Hidemi Nakagawa, Chisei Ra, Shigenori Nakajima, Keizo Waku, Takenori Okada, Takeshi Fukuda, Masaharu Matsukura, Kazuhiko Oki, Hideo Kikkawa, Haruto Hirano, Hidekazu Yamada, Akira Tsuda, Osamu Kaminuma, Tomoko Yoshida, Toshiro Shibuya, Hisao Tomioka, Takao Shimizu, Kunihiko Tamaki, Sohei Makino, Ryutaro Matsumura, Shinpei Furusawa, Terumasa Miyamoto, N. Tomichi, Takayuki Sugiura, Nobuyoshi Takahashi, Masashi Shiiba, Hideo Enokihara, Katsuo Ikezawa, Masaharu Kawabata, Kiyoshi Takatsu, Takashi Takaiwa, Seishi Kishimoto, Kenichi Ochiai, Tomokazu Kakazu, Hirokazu Okudaira, Mitsuomi Hirashima, Tatsuo Yudate, Moritaka Suga, Takashi Izumi, Osamu Urayama, Yoko Nishizaki, Goro Yamada, Kazuko Fujita, Jiang Li, K Umemiya, Hiroshi Saito, Hironori Sagara, Ryo Izutani, Kazusige Futai, Naoki Saita, Masayoshi Nishimoto, Yoshinori Kawabata, Mitsuhiro Osame, Kyoko Yamashiro, Ikkou Higashimoto, Yuichi Nakamura, M Kagami, Tsutomu Sakuma, and Tatsuo Kawashima

Subjects
Gerontology, Index (economics), Immunology, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
1996
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