1. Cytology of Ascitic Fluid in a Patient with Metastasizing Malignant Brenner Tumor of the Ovary
- Author
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Anton Scharl, Johannes F.H. Gauwerky, A. Ahr, Georg Arnold, Serban Costa, and Uwe-Jochen Göhring
- Subjects
Pathology ,medicine.medical_specialty ,Histology ,medicine.diagnostic_test ,business.industry ,Brenner Tumor ,Ovary ,General Medicine ,medicine.disease ,Pathology and Forensic Medicine ,Metastasis ,medicine.anatomical_structure ,Cytopathology ,Cytology ,Biopsy ,medicine ,business ,Hyperchromasia ,Mesothelial Cell - Abstract
Background Transitional cell ("Brenner") tumors represent about 2% of all ovarian neoplasms. Brenner tumors are almost always benign. Malignant Brenner tumors of the ovary resemble urothelial carcinomas and are extremely rare. Case A 77-year-old, white female presented with malignant Brenner tumor in both ovaries as well as lung and abdominal metastases. The cytology of the ascitic fluid revealed many activated mesothelial cells and three-dimensional cell clusters arranged in a papillary pattern. The round to oval nuclei displayed mild anisokaryosis and hyperchromasia but had a quite evenly dispersed opaque or finely granular nucleoplasm. Enfoldings of the nuclear membrane gave them the appearance of so-called coffee bean nuclei. The cytoplasm stained light bluish. Conclusion Knowledge of the cytologic features of ascitic fluid might allow a preoperative diagnosis of malignant, or at least proliferating, ovarian Brenner tumor.
- Published
- 1997