1. Humoral Response and SARS-CoV-2 Infection Risk following the Third and Fourth Doses of the BNT162b2 Vaccine in Dialysis Patients
- Author
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Yael Einbinder, Jeffrey Perl, Naomi Nacasch, Alon Bnaya, Linda Shavit, Daniel Erez, Moshe Shashar, Tamar Halperin, Ayelet Grupper, Sydney Benchetrit, Ori Wand, and Keren Cohen-Hagai
- Subjects
COVID-19 Vaccines ,Renal Dialysis ,SARS-CoV-2 ,Nephrology ,COVID-19 ,Humans ,Viral Vaccines ,Antibodies, Viral ,BNT162 Vaccine - Abstract
The optimal SARS-CoV-2 vaccination schedule in dialysis patients and the potential need for a fourth vaccine dose are debatable. We prospectively assessed the humoral responses to three and four doses of BNT162b2 among dialysis patients. The study included 106 dialysis patients; 60 (56.6%) and 46 (43.4%) received 3 and 4 vaccine doses, respectively. Anti-spike (anti-S) antibody titers significantly increased after the third vaccine dose, followed by a decline, yet still remained higher than all previous measurements. The fourth vaccine dose led to another profound rise in anti-S titers. The absolute increase following the fourth dose correlated with response to the third dose. Infection risk however was similar between patients vaccinated with three or four doses.
- Published
- 2022
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