1. The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests
- Author
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Mototsugu Kato, Shu Hoteya, Kiyohito Tanaka, Hisao Tajiri, Tomohiro Shinozaki, Manabu Muto, Takahisa Matsuda, Kiyonori Kobayashi, Ryota Niikura, Hiroaki Miyata, Shomei Ryozawa, Koji Matsuda, Naomi Uemura, Ichiro Oda, Ken Haruma, Masayuki Kato, Atsuo Yamada, Shinya Kodashima, Hiromu Kutsumi, Mitsuhiro Kida, Ryuichi Iwakiri, Michio Kaminishi, Yutaka Saito, Mitsuhiro Fujishiro, Hironori Yamamoto, Kazuhiko Koike, Chikatoshi Katada, Kazuma Fujimoto, Kazuo Ohtsuka, and Takahiro Horimatsu
- Subjects
Adenoma ,Male ,medicine.medical_specialty ,Thienopyridine ,Pyridines ,Colorectal cancer ,Administration, Oral ,Gastroenterology ,Feces ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Predictive Value of Tests ,Internal medicine ,Antithrombotic ,Humans ,Mass Screening ,Medicine ,False Positive Reactions ,Prospective Studies ,Aged ,Retrospective Studies ,Aged, 80 and over ,Aspirin ,business.industry ,Warfarin ,Anticoagulants ,Cancer ,Colonoscopy ,Middle Aged ,medicine.disease ,Case-Control Studies ,Occult Blood ,030220 oncology & carcinogenesis ,Propensity score matching ,Female ,030211 gastroenterology & hepatology ,Colorectal Neoplasms ,business ,medicine.drug - Abstract
Aim: To clarify whether antithrombotic drugs affect diagnosis using the immunochemical faecal occult blood test (iFOBT) of colorectal neoplasia. Methods: Using the Japan Endoscopy Database from 8 centres between 2015 and 2017, we analyzed data about patients who were iFOBT positive and had received direct oral anticoagulants (DOAC), warfarin, aspirin or thienopyridine. One-to-one matching-analogue propensity score weighted analyses were performed to compare the positive predictive value (PPV) of all neoplasms, invasive and non-invasive colorectal cancers and adenomas between drug users and non-users. All neoplasms included invasive and non-invasive colorectal cancer, and adenomas. Results: We analyzed 197 DOAC users and 196 non-users, 153 warfarin users and 153 non-users, 408 aspirin users and 415 non-users, and 97 thienopyridine users and 97 non-users. No significant differences were observed in the PPV for all neoplasms (56.67 vs. 50.43%), invasive cancer (4.32 vs. 3.53%), non-invasive cancer (15.58 vs. 15.56%) or adenoma (53.13 vs. 48.09%) between the DOAC user and non-user groups. No significant differences were observed in the PPV for all neoplasia, invasive and non-invasive cancer, or adenoma between warfarin, aspirin and thienopyridine use and non-users. Conclusions: DOAC, warfarin, aspirin and thienopyridine use did not decrease the PPVs of the iFOBT used to evaluate all colorectal neoplasia.
- Published
- 2018