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4 results on '"Massimiliano D'Aiuto"'

1. Weekly Dose-Dense Cisplatin-Epirubicin-Paclitaxel Administration with Granulocyte Colony-Stimulating Factor Support Does Not Substantially Improve Prognosis in Extensive Disease Small-Cell Lung Cancer

Author

Pasquale Comella, Roberta D’Aniello, Renato Giordano, Giuseppe Comella, Cosimo Brunetti, Massimiliano D’Aiuto, D Muci, Ignazio Carreca, Giuseppe DeCataldis, Sergio Palmeri, Anna Russo, and Giuseppe Frasci

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Pathology, medicine.medical_treatment, Phases of clinical research, Granulocyte, chemistry.chemical_compound, Internal medicine, polycyclic compounds, medicine, skin and connective tissue diseases, Lung cancer, Cisplatin, Chemotherapy, business.industry, General Medicine, medicine.disease, Granulocyte colony-stimulating factor, medicine.anatomical_structure, Paclitaxel, chemistry, business, medicine.drug, Epirubicin
Abstract

Purpose: The present study was aimed at defining the antitumor activity of the cisplatin-epirubicin-paclitaxel (PET) weekly administration with granulocyte colony-stimulating factor (G-CSF) support in chemonaive small-cell lung cancer patients with extensive disease (ED-SCLC). Methods: Chemonaive ED-SCLC patients received cisplatin 30 mg/sqm, epirubicin 50 mg/sqm and paclitaxel 120 mg/sqm, weekly, with G-CSF (5 µg/kg from day 3 to 5) support, for a maximum of 12 weeks. Results: Thirty-nine patients were treated, for a total of 354 cycles delivered. Eight complete (21%), and 22 partial responses (56%) were recorded, giving a 77% (95% CI = 61–89%) objective response rate (ORR). After 14 (range, 7–28)-month median follow-up, 24 deaths have occurred. Median progression-free and overall survival were 7 months and 11 months, with 1- and 2-year projected survivals of 45 and 24%, respectively. No toxic deaths occurred. Grade 4 neutropenia and thrombocytopenia occurred in 4 (10%) and 1 (3%) patients, respectively. Only one case of neutropenic sepsis was recorded, while hemorrhagic thrombocytopenia was never observed. Emesis, loss of appetite, mucositis and fatigue were the main nonhematological toxicities, being severe in 9, 8, 4 and 7 patients, respectively. Conclusions: The weekly PET combination with G-CSF support represents an active therapeutic approach in chemonaive ED-SCLC patients. However, both ORR and median survival does not seem substantially better than those achievable with a standard regimen. In view of that, and in consideration of the relevant nonhematological toxicity, this approach should not be pursued outside clinical trials.

Published
2005
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2. Biweekly Docetaxel-Irinotecan Treatment with Filgrastim Support Is Highly Active in Antracycline-Paclitaxel-Refractory Breast Cancer Patients

Author

Giuseppe Comella, Giuseppe Frasci, Massimiliano D’Aiuto, R. Thomas, Giuseppe D'Aiuto, Renato Giordano, Gerardo Botti, Vincenzo De Rosa, Pasquale Comella, Paolo Vallone, Liliana Lapenta, Maurizio Di Bonito, and Roberta D’Aniello

Subjects
Adult, Oncology, Cancer Research, medicine.medical_specialty, Filgrastim, Maximum Tolerated Dose, Paclitaxel, Salvage therapy, Breast Neoplasms, Docetaxel, Irinotecan, Disease-Free Survival, chemistry.chemical_compound, Breast cancer, Refractory, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Granulocyte Colony-Stimulating Factor, medicine, Humans, Anthracyclines, Aged, Neoplasm Staging, Salvage Therapy, Dose-Response Relationship, Drug, business.industry, General Medicine, Middle Aged, medicine.disease, Recombinant Proteins, Granulocyte colony-stimulating factor, Surgery, chemistry, Feasibility Studies, Camptothecin, Female, Taxoids, business, medicine.drug
Abstract

Purpose: To evaluate the feasibility and activity of combination treatment with docetaxel (DTX) and irinotecan (CPT-11), given together every other week, combined with filgrastim support, in anthracycline- and paclitaxel-pretreated breast cancer (BC) patients. Patients and Methods: Advanced BC patients pretreated with anthracycline- and paclitaxel-based chemotherapy were eligible. DTX (80 mg/m2) and CPT-11 (100 mg/m2) were given biweekly with filgrastim support (300 µg/day on days 4–7). Results: Fifty patients (48 with metastatic and 2 with locally advanced cancer) were enrolled, with a total of 318 cycles being delivered. Thirty-one patients had visceral localizations. All patients had received epirubicin plus paclitaxel, with or without cisplatin, as front-line treatment for advanced disease. Overall, fatigue and diarrhea were the main chemotherapy-related toxicities in this study, being severe in 10 (20%) and 4 (8%) patients. Grade 3 or 4 neutropenia and thrombocytopenia occurred in 18 (36%) and 6 (12%) patients, respectively. Red blood cell transfusions were required in 4 patients. A total of 32 objective responses were registered (overall response rate, ORR = 64%, 95% confidence interval = 49–77%), including 8 complete responses (16%). An additional 8 patients showed stable disease. After a median follow-up of 18 (range 4–29) months, 30 patients were still alive, and 19 were progression free; median progression-free and overall survivals were 10 and 23 months, respectively. Conclusions: Biweekly DTX/CPT-11 with G-CSF support is a well-tolerated and highly effective approach in anthracycline-/paclitaxel-pretreated patients. The very promising ORR and survival outcome observed in this subset of patients with a poor prognosis suggest that this regimen might play a major role in the management of this disease.

Published
2005
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3. Contents Vol. 68, 2005

Author

Takashi Sugita, Takaaki Kondo, Karina Fincati, Alberto Chiappori, G. De Cataldis, Tadahiko Kubo, S. Spada, Jayesh A. Prajapati, Hideaki Toyoshima, Christoph Rochlitz, Anthony T.C. Chan, Patrick J. Loehrer, Dong Kyun Park, Marcella Occelli, Laura Bertolotti, Anna Mastrosimini, Donato F. Altomare, L. Capussotti, Michele Milella, Cecilia Nisticò, Ming Gao, Nitin Chakravarti, Carter W.N. Cheng, Masayuki Hino, Eun Kyung Cho, Yoshimi Sugama, Mario Correale, Gabriella Uhercsák, Krisztina Boda, Masafumi Ikeda, Chih-Hsin Yang, Eustachio Ruggieri, Neal J. Meropol, Christina Liossi, Shinkan Tokudome, Gabriel Civiello, Masayo Kojima, Robert C. F. Leonard, Nicola Marzano, Luisa Barzon, Vincenzo De Rosa, S. Palmeri, R. Martí, Kazuhiro Yasuda, Alfred Rademaker, Paolo Carlini, Prabhudas S. Patel, Daniel Fink, Chih-Yen Chien, Louis W.C. Chow, A. Farris, Toshihiro Matsuo, Luciano Frontini, Marc Salzberg, Shinichi Tsutsui, Eric Francois, P. Gabriele, Giulia Masi, Woon Ki Lee, Shigeru Tatebe, Pasquale Comella, Dayna S. Early, Serafino Conforti, Helmut Messmann, Anthony P.C. Yim, Yu-Chie Yu, Mitsuo Ochi, Ann-Lii Cheng, M. Danova, Takuji Okusaka, Hui-Chun Chen, Hiroko Fukushima, Min-Chun Chen, Jae Hoon Lee, Gerardo Botti, M. Vera, Amit Verma, Pan-Chyr Yang, Ornella Garrone, Henry N. Wagner, H. Bourgeois, E. Sperti, A. Misino, Sudhir Bahadur, H. Perrier, Upendra M. Rawal, J.-P. Wiksten, M. Hebbar, Sadao Suzuki, E. Dorval, Daniel K.H. Tong, Yu-Fei Jiao, B. Massidda, Benedetta D'Attoma, Jacqueline Whang-Peng, Hidefumi Higashi, Norihiko Hayakawa, Seok-Ah Im, Federica Cuppone, Lucia Del Mastro, M. Cajozzo, L. Palmeri, Michihiko Hirayama, Tilmann Steinmetz, J.Y. Douillard, V. Leonardi, Kenichi Yamaguchi, George R. Simon, See Ching Chan, Ranju Ralhan, Hiroshi Inoue, Yoriko Takezako, A. Mangiameli, Giuseppe Comella, Conrad Lee, Paolo Vallone, M. Karthaus, Se Hoon Park, A. Magnino, Nootan Kumar Shukla, Pankaj M. Shah, S. Puig, Chih-Hung Hsu, G. Filippelli, Chong-Jong Wang, F. Ferraù, G. Comella, Koji Tamakoshi, Pei-Yen Yeh, Al B. Benson, Shunichi Tsujitani, Hiroyuki Tsuchiya, Roland Greinwald, Kun-Huei Yeh, Jatinder Kaur, Hiroshi Yatsuya, Ching-Yeh Hsiung, C. Conill, J. Malvehy, Shin-ichi Nakamura, Giuseppe Frasci, Fu-Min Fang, Soon Nam Lee, Caio Rocha-Lima, J.J. Grau, Sandro Barni, Nobuyuki Shirai, Lai Ngor Wong, Bruce E. Johnson, Benny Zee, Toru Mukohara, Beat Thürlimann, Shotaro Oro, Massimiliano D’Aiuto, Herng-Chia Chiu, P. Barthélemy, Keiji Sato, S. Nordling, M. Aglietta, Akinori Takagane, Li Zhang, Harald Ballo, Winnie Yeo, M. Vaglica, Wolgang Abenhardt, Maria Notarnicola, Hiroshi Ikeda, Scott J. Antonia, R. Thomas, Gianluigi Ferretti, J. Domingo-Domènech, Ulrich Kleeberg, Shoichi Era, Rüdiger Behrens, Takehisa Suekane, Charles Williams, Kwok Chi Lam, Anupam Kumar, M. Gatti, B. Mellado, Masahiko Ohsawa, T. Castel, Hideki Ueno, Maria Gabriella Caruso, Miyuki Kawado, Tetsuo Hotta, Antonio Febbraro, Meera Mathur, Mary F. Mulcahy, M. Lundin, Gianfilippo Bertelli, Kotaro Ozasa, Gerold Bepler, Young S. Oh, Tony Mok, Dirk Behringer, Roger von Moos, Suryanaryana V.S. Deo, Kosuke Suzuki, Rozalia Hajnal-Papp, R. Molina, Monia Pacenti, Vito Guerra, Yoshinori Ito, R. Faggiuolo, Yoshikazu Kagami, E. Iannitto, Francesco Cognetti, Siddhartha Datta Gupta, Makiko Ueda, Tamotsu Sugai, J. Isola, Giorgio Palù, Yeonho Park, László Thurzó, P. Gascón, Chi-Long Chen, Renato Giordano, Yoshiyuki Watanabe, C. Martin, Karen Chak, Hans-Peter Boeck, Hiroaki Saito, Herman Wong, Thomas Geer, Soo Mee Bang, Jörg Schimke, Masahide Ikeguchi, Hervé Bonnefois, C. Haglund, Hans-Jörg Senn, D. Regge, Pasi A. Jänne, C. Montagut, Beena P. Patel, Giuseppe D'Aiuto, Shilpi Soni, Kenji Wakai, J.M. Auge, Tina K. Dave, Carlo Garufi, Riad R. Azar, J. Bennouna, Dong Bok Shin, Emilio Bria, Koji Suzuki, Manfred Kindler, G. Condemi, Shoji Shimose, Anna-Lisa Stefani, Barbara Vanni, M.C. Macaluso, P. Massucco, Wen-Ling Tsai, Rakesh Rawal, Zsuzsanna Kahán, Eric B. Haura, Maurizio Di Bonito, Masaki Mori, S.V.S. Deo, Edmondo Terzoli, D. Mayeur, J. Lundin, Liliana Lapenta, Dietrich Braumann, Akiko Tamakoshi, Yoshihiro Ikura, Masamichi Suzuki, Wataru Habano, Shuji Hashimoto, Roberta D’Aniello, and Chigusa Morizane

Subjects
Cancer Research, Oncology, General Medicine
Published
2005
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4. Subject Index Vol. 68, 2005

Author

Donato F. Altomare, M. Vaglica, Cecilia Nisticò, Ming Gao, Masayuki Hino, Eun Kyung Cho, Yoshimi Sugama, Mario Correale, B. Mellado, Chih-Hsin Yang, Gabriella Uhercsák, Renato Giordano, Hideki Ueno, Antonio Febbraro, Meera Mathur, Gerold Bepler, Masahide Ikeguchi, Karen Chak, Hans-Peter Boeck, Gianfilippo Bertelli, M. Lundin, Mary F. Mulcahy, Hervé Bonnefois, Young S. Oh, Kotaro Ozasa, Kwok Chi Lam, Dirk Behringer, Suryanaryana V.S. Deo, Herman Wong, Hiroaki Saito, Yu-Fei Jiao, D. Regge, Pasi A. Jänne, C. Montagut, Rozalia Hajnal-Papp, Giuseppe D'Aiuto, R. Molina, Kenji Wakai, Li Zhang, Monia Pacenti, Kosuke Suzuki, Pankaj M. Shah, J.M. Auge, Winnie Yeo, Vito Guerra, Yoshinori Ito, M. Vera, Carlo Garufi, Pei-Yen Yeh, Caio Rocha-Lima, B. Massidda, T. Castel, Tina K. Dave, Maria Notarnicola, Luisa Barzon, Prabhudas S. Patel, Chih-Yen Chien, Beat Thürlimann, Thomas Geer, George R. Simon, Jörg Schimke, Pan-Chyr Yang, C. Haglund, A. Farris, Toshihiro Matsuo, G. De Cataldis, Kenichi Yamaguchi, Nobuyuki Shirai, Lai Ngor Wong, S. Spada, Krisztina Boda, Toru Mukohara, Gianluigi Ferretti, Soo Mee Bang, Christoph Rochlitz, G. Comella, Louis W.C. Chow, Wataru Habano, Sudhir Bahadur, Upendra M. Rawal, Kazuhiro Yasuda, Shuji Hashimoto, Roberta D’Aniello, P. Gascón, Masahiko Ohsawa, U.R. Kleeberg, Dayna S. Early, Marc Salzberg, Masayo Kojima, J.J. Grau, Woon Ki Lee, Shigeru Tatebe, Giulia Masi, Lucia Del Mastro, Anupam Kumar, Soon Nam Lee, Tony Mok, Anthony P.C. Yim, Robert C. F. Leonard, Chigusa Morizane, László Thurzó, Hiroshi Ikeda, Min-Chun Chen, Jae Hoon Lee, Emilio Bria, Riad R. Azar, Al B. Benson, M. Danova, Takuji Okusaka, Hui-Chun Chen, Tilmann Steinmetz, Shin-ichi Nakamura, G. Filippelli, Giuseppe Comella, Keiji Sato, S. Nordling, Wolgang Abenhardt, Shoji Shimose, M. Cajozzo, Mitsuo Ochi, Hiroyuki Tsuchiya, Giuseppe Frasci, Se Hoon Park, Amit Verma, Hideaki Toyoshima, Siddhartha Datta Gupta, Hiroshi Inoue, Hiroko Fukushima, J. Bennouna, C. Conill, E. Sperti, Eustachio Ruggieri, Barbara Vanni, Jatinder Kaur, R. Faggiuolo, Francesco Cognetti, Ornella Garrone, Marcella Occelli, Gerardo Botti, Norihiko Hayakawa, Tamotsu Sugai, Chih-Hung Hsu, Maurizio Di Bonito, M. Karthaus, J. Domingo-Domènech, S. Puig, J. Isola, Hidefumi Higashi, Laura Bertolotti, Takashi Sugita, Wen-Ling Tsai, Rakesh Rawal, Koji Tamakoshi, Zsuzsanna Kahán, Eric B. Haura, Yoshikazu Kagami, L. Palmeri, Jacqueline Whang-Peng, A. Mangiameli, S.V.S. Deo, E. Iannitto, Tadahiko Kubo, Edmondo Terzoli, Roland Greinwald, Makiko Ueda, Hiroshi Yatsuya, Daniel Fink, Sandro Barni, Fu-Min Fang, Dong Kyun Park, Chong-Jong Wang, F. Ferraù, D. Mayeur, Helmut Messmann, L. Capussotti, Michele Milella, M.C. Macaluso, Neal J. Meropol, Christina Liossi, Gabriel Civiello, Giorgio Palù, E. Dorval, A. Misino, J. Malvehy, Akinori Takagane, Bruce E. Johnson, P. Massucco, J. Lundin, Harald Ballo, Conrad Lee, Paolo Vallone, Hans-Jörg Senn, Yu-Chie Yu, Benedetta D'Attoma, Benny Zee, Ann-Lii Cheng, H. Perrier, S. Palmeri, Beena P. Patel, Scott J. Antonia, Kun-Huei Yeh, J.-P. Wiksten, M. Hebbar, Luciano Frontini, Yeonho Park, R. Thomas, Liliana Lapenta, Shilpi Soni, Rüdiger Behrens, Chi-Long Chen, Takaaki Kondo, Massimiliano D’Aiuto, Akiko Tamakoshi, Charles Williams, Anthony T.C. Chan, Patrick J. Loehrer, P. Barthélemy, Yoshihiro Ikura, Anna Mastrosimini, Masamichi Suzuki, Nitin Chakravarti, Carter W.N. Cheng, Shotaro Oro, Masaki Mori, Masafumi Ikeda, Yoshiyuki Watanabe, Nicola Marzano, M. Gatti, Dong Bok Shin, C. Martin, Shoichi Era, Roger von Moos, Vincenzo De Rosa, R. Martí, Pasquale Comella, Sadao Suzuki, V. Leonardi, Takehisa Suekane, Maria Gabriella Caruso, Miyuki Kawado, Tetsuo Hotta, Koji Suzuki, Manfred Kindler, G. Condemi, Anna-Lisa Stefani, Shinichi Tsutsui, Eric Francois, P. Gabriele, Serafino Conforti, Henry N. Wagner, Seok-Ah Im, Federica Cuppone, A. Magnino, Nootan Kumar Shukla, Alfred Rademaker, Paolo Carlini, Shunichi Tsujitani, Daniel K.H. Tong, Michihiko Hirayama, See Ching Chan, Ranju Ralhan, Ching-Yeh Hsiung, Karina Fincati, Alberto Chiappori, Jayesh A. Prajapati, Dietrich Braumann, Herng-Chia Chiu, M. Aglietta, Shinkan Tokudome, H. Bourgeois, J.Y. Douillard, and Yoriko Takezako

Subjects
Cancer Research, Index (economics), Oncology, Statistics, Subject (documents), General Medicine, Mathematics
Published
2005
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