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1. Contents Vol. 87, 2014

Author

Masakazu Yoshioka, Hugo Goulart de Oliveira, Manuel Schlageter, Philipp Latzin, Marina Saetta, Koji Sakamoto, Sylvia Verbanck, Samuel V. Kemp, Naohiro Watanabe, Osamu Nishiyama, Michael Tamm, Ravi Mahadeva, Manuel G. Cosio, Florian Singer, Salman Siddiqui, Alexandar Tzankov, Hiroyuki Taniguchi, Tsogyal D. Latshang, Werner Druck Medien Ag, Yoshinori Hasegawa, Richard Kraemer, Amisha Singapuri, Liesbeth De Meirleir, Satz Mengensatzproduktion, Malcolm Kohler, Anne Malfroot, Konrad E. Bloch, Kodai Kawamura, Harry J.M. Groen, Lutz Freitag, Eef Vanderhelst, Walter Vincken, Arschang Valipour, Armin Ernst, Daniela Gompelmann, Spasenija Savic, Mark Wiese, Lukas Bubendorf, Steven Corkill, Gerard J. Criner, Yasuhiro Kondoh, Christian M. Lo Cascio, Junya Fukuoka, Kenzo Ono, Dirk-Jan Slebos, Felix J.F. Herth, Bruce Thompson, Kensuke Kataoka, Kazuya Ichikado, Zaid Zoumot, Pallav L. Shah, Riccardo Cazzuffi, Per E. Gustafsson, Kathleen Jahn, Sherif Gonem, Daniel Schuermans, Tomoki Kimura, Ralf Eberhardt, Jos A. Stigt, Thomas Fehr, and Moritaka Suga

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
2014
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2. Gemeinsame Jahresversammlung der Schweizerische Gesellschaft für Pneumologie / Société Suisse de Pneumologie. Schweizerische Gesellschaft für Pädiatrische Pneumologie / Société Suisse de Pneumologie Pédiatrique. Schweizerische Gesellschaft für Thoraxchirurgie / Société Suisse de Chirurgie Thoracique. Schweizerische Vereinigung für Endoskopie Personal / Association Suisse du Personnel en Endoscopie. 8.-9. Mai 2014, Interlaken: Abstracts

Author

Harry J.M. Groen, Christian M. Lo Cascio, Dirk-Jan Slebos, Steven Corkill, Sherif Gonem, Daniel Schuermans, Alexandar Tzankov, Tomoki Kimura, Hiroyuki Taniguchi, Jos A. Stigt, Florian Singer, Satz Mengensatzproduktion, Osamu Nishiyama, Eef Vanderhelst, Yasuhiro Kondoh, Tsogyal D. Latshang, Michael Tamm, Amisha Singapuri, Samuel V. Kemp, Riccardo Cazzuffi, Ravi Mahadeva, Lutz Freitag, Per E. Gustafsson, Kenzo Ono, Marina Saetta, Hugo Goulart de Oliveira, Kazuya Ichikado, Thomas Fehr, Manuel Schlageter, Moritaka Suga, Werner Druck Medien Ag, Walter Vincken, Yoshinori Hasegawa, Zaid Zoumot, Arschang Valipour, Liesbeth De Meirleir, Masakazu Yoshioka, Konrad E. Bloch, Kodai Kawamura, Pallav L. Shah, Philipp Latzin, Bruce Thompson, Felix J.F. Herth, Salman Siddiqui, Manuel G. Cosio, Lukas Bubendorf, Kensuke Kataoka, Malcolm Kohler, Junya Fukuoka, Richard Kraemer, Kathleen Jahn, Ralf Eberhardt, Anne Malfroot, Sylvia Verbanck, Daniela Gompelmann, Mark Wiese, Naohiro Watanabe, Gerard J. Criner, Spasenija Savic, Armin Ernst, and Koji Sakamoto

Subjects
Pulmonary and Respiratory Medicine, Gynecology, medicine.medical_specialty, business.industry, medicine, business
Published
2014
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3. Efficacy of Azithromycin for Treatment of Acute Exacerbation of Chronic Fibrosing Interstitial Pneumonia: A Prospective, Open-Label Study with Historical Controls

Author

Kodai Kawamura, Kazuya Ichikado, Masakazu Yoshioka, and Moritaka Suga

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Exacerbation, Azithromycin, Lung injury, Idiopathic pulmonary fibrosis, Japan, Internal medicine, Clinical endpoint, medicine, Humans, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, Dose-Response Relationship, Drug, business.industry, Mortality rate, medicine.disease, Survival Analysis, Anti-Bacterial Agents, Clinical trial, Treatment Outcome, Chronic Disease, Disease Progression, Administration, Intravenous, Drug Therapy, Combination, Female, Steroids, Drug Monitoring, Lung Diseases, Interstitial, business, Fluoroquinolones, medicine.drug
Abstract

Background: Acute exacerbation of chronic fibrosing interstitial pneumonia (AE-CFIP) is an often fatal condition with no established treatment. Recently, macrolides were found to be beneficial in cases of acute lung injury. Objectives: To examine the clinical effectiveness and safety of intravenous azithromycin in patients hospitalized for AE-CFIP. Methods: A prospective, open-label study with historical controls was conducted. Twenty consecutive patients with AE-CFIP received azithromycin. They were compared with a historical cohort treated with fluoroquinolone (n = 56). All patients received high-dose steroid pulse therapy. The primary end point was mortality at 60 days. The secondary end point was safety of intravenous azithromycin in patients with AE-CFIP. Inverse probability of treatment weighting (IPTW) using the propensity score was performed to investigate the relationship between azithromycin use and survival time. Results: Mortality was significantly lower in the patients treated with azithromycin than in those treated with fluoroquinolone (mortality rate at 60 days: 20 vs. 69.6%, p < 0.001; median survival time: not reached vs. 29.5 days, p < 0.001). The IPTW adjusted hazard of mortality at 60 days in patients receiving azithromycin was 0.17 (95% CI 0.05-0.61). No serious adverse events were observed. Conclusions: Azithromycin was associated with improved outcomes in patients with AE-CFIP. Further studies are needed to verify this finding (Clinical trial JMA-IIA00095).

Published
2014
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