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1. The Relationship of NT-proBNP and Dialysis Parameters with Outcome of Incident Haemodialysis Patients: Results from the Membrane Permeability Outcome Study

Author

Annemieke Dhondt, Marian Klinger, Thierry Hannedouche, Vincenzo La Milia, Isabel Berdud, Sergio Stefoni, Stefan H. Jacobson, Adelheid Gauly, Alejandro Martin-Malo, Thierry Krummel, Francesco Locatelli, Hervé Maheut, Raymond Vanholder, Juan M. Lopez Gomez, Claudio Ronco, Locatelli F, Hannedouche T, Martin-Malo A, Jacobson SH, Vanholder R, Ronco C, La Milia V, Lopez Gomez JM, Stefoni S, Maheut H, Klinger M, Krummel T, Dhondt A, Berdud I, and Gauly A.

Subjects
Adult, Male, NT-PROBNP, Multivariate statistics, medicine.medical_specialty, Membrane permeability, BRAIN NATRIURETIC PEPTIDE (BNP), medicine.medical_treatment, Urology, CARDIOVASCULAR DISEASES, Permeability, Renal Dialysis, Risk Factors, Natriuretic Peptide, Brain, Humans, Medicine, In patient, Prospective Studies, Renal Insufficiency, cardiovascular diseases, HAEMODIALYSIS, Dialysis, Survival analysis, Aged, Proportional Hazards Models, business.industry, Proportional hazards model, Membranes, Artificial, Hematology, General Medicine, Middle Aged, HIGH FLUX MEMBRANE, Brain natriuretic peptide, medicine.disease, Survival Analysis, Peptide Fragments, Surgery, Treatment Outcome, Nephrology, Heart failure, Female, business, Biomarkers, hormones, hormone substitutes, and hormone antagonists
Abstract

Background/Aims: The association of raised levels of natriuretic peptides with elevated risk of mortality was investigated in the present analysis of the Membrane Permeability Outcome study. Methods: N-terminal probrain type natriuretic peptide (NT-proBNP) was measured in 618 incident haemodialysis patients, randomised to either high-flux or low-flux. Characteristics of patients with NT-proBNP levels below or above the median were descriptively analysed and survival analysis was performed. Results: Median NT-proBNP value was 2,124 pg/ml, with 1,854 pg/ml in the high-flux and 2,919 pg/ml in the low-flux group. Survival probability was lowest in patients with both a history of cardiovascular disease and NT-proBNP values above the median (p < 0.001). A multivariate Cox proportional hazard model showed interaction between presence of cardiovascular diseases and NT-proBNP levels above the median. Conclusions: NT-proBNP is an independent predictor of mortality also in incident haemodialysis patients. Lower concentrations associated with high-flux dialysis suggest a possible biological link to improved survival in this group.

Published
2013
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2. Selected Abstracts from the 31th International Vicenza Course on Critical Care Nephrology. Vicenza, June 11-14, 2013

Author

Werner Beck, Catarina Teixeria, Ian T. Baldwin, Boris Zingerman, Franz Techert, D. Cruz, Irene Capelli, Sylvain J. Marchais, Nathan W. Levin, Jeroen P. Kooman, Cristina Marelli, Josipa Radic, Néstor Fontseré, Satz Mengensatzproduktion, Michael Bergman, Jeong Chul Kim, A. Bonaccorsi, Daniele Galavotti, M. Rassu, Annemie Dhondt, Gérard M. London, Golaun Odabaei, Gerald B. Appel, F. Furlan, Zaccaria Ricci, Michael Etter, Robert J. Kossmann, Rachel S. Levy-Drummer, Yang Shen, Vedran Kovacic, Mislav Radic, Francesco Alviano, Hee Chan Kim, Hertzel Salman, R. Grillone, Massimo de Cal, Sergio Picardo, Dragan Ljutic, Giuseppe Cianciolo, Ji Hyun Kim, Albert Power, Akash Nayak, Yaacov Ori, Grazia Maria Virzì, Len A. Usvyat, Claudio Laterza, Paola Cogo, Elaine Ku, Carla M. Nester, Maurizio Muraca, Aleix Cases, Hans Dietrich Polaschegg, Matteo Di Nardo, Elena Della Bella, Thierry Krummel, Milenka Sain, Roberta Costa, S. Cazzavillan, Vincenzo La Milia, Elisabet Massó, Maria Cappuccilli, Rod S. Passman, Stephan Thijssen, Hanna Bessler, Vito M. Campese, Keith C. Norris, Marian Klinger, Matteo Brolgli, M. Carrera, Alice Sue Appel, Bruno Pannier, Thierry Hannedouche, Franz Kappel, G M Virzì, Raymond Vanholder, Stefania Marzocco, Nevin M. Katz, Ulrike Haug, Peter Kotanko, Domenico Tartaglia, Tai-Gen Cui, Heike Lebsanft, Gaetano La Manna, Reinhold Deppisch, Maria Laura Angelini, Ted Toffelmire, Melvin Bonilla-Felix, Dinna N. Cruz, Maria Luisa Sirico, Jing Liu, V. Corradi, Elisa Scalzotto, Anja Kruse, Nosratola D. Vaziri, Uzi Gafter, Anna Giuliani, Stefan H. Jacobson, Fabrizio Dal Piaz, Stefano Picca, Marie Baldwin, George A. Kaysen, Jing Huang, Giuseppina Autore, Claudio Ronco, Frank A. Gotch, Marta Arias, C. Ronco, Corrado Bellini, Manel Vera, Juan M. Lopez Gomez, Alessandra Brocca, A. Vázquez-Rangel, Druck Reinhardt Druck Basel, Ivo Jelicic, Rosa Luciano, Josep M. Campistol, Anna Clementi, P. Frisone, Serena Torraca, Yuedong Wang, Fang Sun, Huijuan Mao, Francisco Maduell, Yi-Lun Zhou, A. Morea, Volker Wizemann, Francesco Garzotto, Bernard Canaud, Isabel Berdud, Ada Dormi, Francesco Locatelli, Manish Kaushik, Hervé Maheut, M. De Cal, Yosef S. Haviv, A. Brendolan, Federico Nalesso, Li-Jie Ma, Eungtaek Kang, Lucia Di Micco, Francesca Stoppa, Ingrid Ledebo, Frank Prosl, Daniele Marcelli, Alejandro Martin-Malo, Alessio Ficarella, Lourdes Blanca-Martos, Mauro Neri, Sudhir K. Bowry, Sergio Stefoni, Biagio Di Iorio, Adelheid Gauly, and Gabriele Donati

Subjects
Nephrology, medicine.medical_specialty, business.industry, Family medicine, Internal medicine, medicine, Hematology, General Medicine, Intensive care medicine, business
Published
2013
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3. Abstracts

Author

Elena Della Bella, Roberta Costa, Carla M. Nester, Aleix Cases, Elisabet Massó, Stefania Marzocco, Giuseppe Cianciolo, Franz Techert, Yi-Lun Zhou, Lourdes Blanca-Martos, Maria Laura Angelini, Hanna Bessler, Keith C. Norris, Ted Toffelmire, Nosratola D. Vaziri, Druck Reinhardt Druck Basel, A. Morea, Rachel S. Levy-Drummer, Sergio Stefoni, Biagio Di Iorio, Adelheid Gauly, Ada Dormi, Rosa Luciano, Gerald B. Appel, Gabriele Donati, Fang Sun, Josep M. Campistol, Huijuan Mao, Marian Klinger, Serena Torraca, F. Furlan, Alice Sue Appel, Elisa Scalzotto, Jeroen P. Kooman, Volker Wizemann, Bruno Pannier, G M Virzì, S. Cazzavillan, Anna Clementi, Albert Power, Thierry Hannedouche, Heike Lebsanft, Nathan W. Levin, Francesco Garzotto, Bernard Canaud, Isabel Berdud, Cristina Marelli, Gaetano La Manna, Yuedong Wang, George A. Kaysen, Corrado Bellini, Ulrike Haug, Uzi Gafter, Michael Etter, P. Frisone, Akash Nayak, Maria Luisa Sirico, R. Grillone, M. De Cal, Ian T. Baldwin, Claudio Ronco, Alessio Ficarella, Francisco Maduell, Hertzel Salman, Anja Kruse, Zaccaria Ricci, Maria Cappuccilli, Dragan Ljutic, Sergio Picardo, Vedran Kovacic, Dinna N. Cruz, Gérard M. London, Satz Mengensatzproduktion, Francesco Locatelli, Paola Cogo, Stephan Thijssen, Josipa Radic, Hee Chan Kim, Jeong Chul Kim, Franz Kappel, Manish Kaushik, Yang Shen, Stefano Picca, Matteo Di Nardo, Elaine Ku, Nevin M. Katz, A. Bonaccorsi, Giuseppina Autore, Jing Huang, Hans Dietrich Polaschegg, Mislav Radic, Francesco Alviano, Thierry Krummel, Rod S. Passman, Hervé Maheut, Tai-Gen Cui, Frank A. Gotch, Fabrizio Dal Piaz, Ji Hyun Kim, C. Ronco, Jing Liu, Manel Vera, Marta Arias, Francesca Stoppa, Massimo de Cal, Daniele Galavotti, Claudio Laterza, Yosef S. Haviv, Domenico Tartaglia, Maurizio Muraca, Yaacov Ori, Milenka Sain, Anna Giuliani, Grazia Maria Virzì, Len A. Usvyat, Juan M. Lopez Gomez, M. Rassu, Annemie Dhondt, A. Brendolan, V. Corradi, Golaun Odabaei, Reinhold Deppisch, Marie Baldwin, Vito M. Campese, Irene Capelli, Peter Kotanko, Melvin Bonilla-Felix, Michael Bergman, Robert J. Kossmann, Federico Nalesso, Li-Jie Ma, Raymond Vanholder, Matteo Brolgli, Eungtaek Kang, M. Carrera, Lucia Di Micco, Néstor Fontseré, Vincenzo La Milia, Werner Beck, Mauro Neri, Catarina Teixeria, Ingrid Ledebo, Stefan H. Jacobson, Boris Zingerman, Sylvain J. Marchais, Frank Prosl, Daniele Marcelli, Alejandro Martin-Malo, Sudhir K. Bowry, D. Cruz, Ivo Jelicic, Alessandra Brocca, and A. Vázquez-Rangel

Subjects
medicine.medical_specialty, Nephrology, business.industry, medicine.medical_treatment, Medicine, Hematology, General Medicine, business, medicine.disease, Intensive care medicine, Dialysis, Kidney disease
Published
2013
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4. A Program of Physical Rehabilitation during Hemodialysis Sessions Improves the Fitness of Dialysis Patients

Author

Tomasz Gołębiowski, Krzysztof Letachowicz, Marian Klinger, Mariusz Kusztal, Wioletta Dziubek, Beata Strempska, Magdalena Krajewska, Wacław Weyde, Katarzyna Madziarska, and Marek Woźniewski

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Walking, Dialysis patients, End stage renal disease, Physical medicine and rehabilitation, Quality of life, Renal Dialysis, medicine, Humans, Cycle exercise, Muscle Strength, Dialysis, Aged, Rehabilitation, business.industry, General Medicine, Middle Aged, Physical Fitness, Nephrology, Exercise Test, Muscle strength, Physical therapy, Female, Hemodialysis, Cardiology and Cardiovascular Medicine, business
Abstract

Aim: The aim of the present study was to evaluate the influence of cycle exercise during hemodialysis (HD) on patients’ physical proficiency, muscle strength, quality of life and selected laboratory parameters. Patients and Methods: In a group of 29 (15 female, 14 male) HD patients (age 64.2 ± 13.1 years), 3 months of cycle training during dialysis sessions was performed. The following data were analyzed: strength of lower extremities (six-minute walk test, isokinetic knee extension, flexion peak torque), nutrition parameters (albumin, BMI), inflammation intensity (CRP, IL-6), and quality of life (SF-36v2). Results: In the six-minute walk test, the increase in walk velocity was 4% (3.56 km/h before and 3.73 km/h after cycle training; p < 0.01). At angular velocity (AV) of 60°/s, extension peak torque in the knee joint rose by 7% and at AV of 300°/s by 4% (p = 0.04). Flexion peak torque at AV of 180°/s increased by 13% (p = 0.0005). The program does not influence nutrition or inflammation parameters. No complications directly related to exercise were observed. Conclusion: Cycle exercise during dialysis is safe even in older HD patients with multiple comorbidities. It results in a significant increase in general patient walking ability and in a gain in lower extremity muscle strength.

Published
2012
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5. Etiology of Increased Enzymuria in Different Morphological Forms of Glomerulonephritis

Author

Zofia Marchewka, Tomasz J. Kuźniar, Marian Klinger, Jadwiga Lembas-Bogaczyk, and Jakub Kuźniar

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Glomerulonephritis, Membranoproliferative, Physiology, Population, urologic and male genital diseases, Glomerulonephritis, Membranous, Excretion, chemistry.chemical_compound, Glomerulonephritis, Physiology (medical), Internal medicine, Acetylglucosaminidase, medicine, Leukocyte degranulation, Humans, Minimal change disease, education, Glucuronidase, Creatinine, education.field_of_study, Proteinuria, urogenital system, Chemistry, Elastase, General Medicine, Middle Aged, medicine.disease, Lupus Nephritis, Endocrinology, Nephrology, Female, medicine.symptom
Abstract

Background: High urinary excretion of lysosomal enzymes is thought to reflect tubulointerstitial damage and is observed both in the acute and chronic phases of various morphological forms of glomerulonephritis (GN). It is related to the degree of proteinuria and secondary interstitial inflammatory process. N-acetyl-β-D-glucosaminidase (NAG) and β-glucuronidase (β-GR) are the most commonly used markers of tubulointerstitial injury. NAG and β-GR are also contained in azurophilic granulations of polymorphonuclear leukocytes (PMNs) and may be released during the activation of PMNs. Aims: The aim of this study was to elucidate the role of PMN degranulation in causing the increase of urinary excretion of lysosomal enzymes that is observed in glomerulonephritis. Material and Methods: We analyzed the urinary excretion of NAG, its B isoenzyme NAG-B, β-GR and leukocyte elastase (EL), in 91 patients with morphologically different primary and secondary glomerulopathies, and in 12 healthy controls. Results: Excretion of NAG, NAG-B and β-GR were statistically significantly higher in all GN patients in comparison to healthy controls. In the whole analyzed GN population significant correlations between amount of proteinuria and excretion of NAG, NAG-B and β-GR were ascertained. In subgroup analysis NAG excretion was significantly correlated with proteinuria in patients with diffuse proliferative GN (PGN), mesangiocapillary GN (MCGN), and minimal change disease (MCD). There was a significant correlation between NAG-B and proteinuria in MCD and PGN patients. There was a significant relationship of β-GR and EL with proteinuria and EL with NAG in the PGN group. Significant relationships between serum creatinine and excretion of EL but not NAG, NAG-B, or β-GR were observed in the whole examined group. Conclusions: Increased urinary excretion of elastase, with concomitant high proteinuria and NAG excretion in patients with proliferative GN may indicate that leukocyte degranulation is an additional source of enzymuria in the primary i.e. glomerular inflammatory process. Significant relationship between EL excretion and serum creatinine may indicate that EL released from PMN may also participate in the secondary i.e. interstitial injury that is decisive in the progression of GN.

Published
2004
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6. Contents, Vol. 72, 1996

Author

Hiroshi Toma, L. Raffaele, V. Dalmastri, Filippo Salvati, Divyesh M. Bhatt, Hiroshi Ishida, Hikaru Sugimoto, Juan M. Gonzalez, Salih Hazar, J. Guiserix, Kyoko Kurose, V. Stefanović, Majed Odeh, Hiroshi Inuma, Kamberi Perparim, Nilwarangkur S, L. Perini, F. Locatelli, Peter Nilsson-Ehle, Shigeo Takebayashi, N. Seyrek, G. Paunović, Vivette D. D'Agati, J.C. Boulanger, Mohamed A. El-Shahawy, Smaragdi Antonopoulou, M. Dapporto, Hiroshi Mabuchi, Syuko Yamamoto, Hiroshi Kitamura, Yong Goo Kim, A.G. Brox, G. Erba, R. Margreiter, Hiroshi Osawa, Hiroyoshi Matsukura, M. Vedovato, Der-Cherng Tarng, Hiromichi Suzuki, Ching-Huai Huang, Constantinos A. Demopoulos, R.F. Gagnon, Yahya Sagliker, D Di Landro, M. Oh, Shuichi Hatakeyama, Panos Ziroyiannis, A. Michault, Masateru Kawabata, P. Finielz, I. Guarnori, R. Pérez-García, Satoru Tsunoda, Shinsuke Nomura, F. Malacarne, Zensuke Ota, Byung Kee Bang, G. Ricci, Per Kjellstrand, Sompong Ong-ajyooth, Y. Sagliker, Gengo Osawa, Mark W. Majesky, Tadashi Asami, Hideaki Yamabe, L.P.W.J. van den Heuvel, Young Ok Kim, F. Fabrizi, Satsuki Yamada, H.A. Jalil, Arie Oliven, Takao Kohsaka, Hans-Georg Classen, Arturo Borsatti, B. de Cagny, R. Mallmann, M. Lago, Christos Iatrou, Yoshiharu Hiratsuka, Tanekazu Harada, Luan D. Truong, Ank Nurol, Masaki Kobayashi, Watanachai Susaengrat, Yoshiko Fujita, G.F. Romagnoli, Saime Paydas, Rainer Nobiling, D. Oefner, J.P. Mallie, George Moustakas, Syunji Ishihara, Zhi-Hong Liu, Kogo Onodera, Sumalee Nimmannit, G. Devulder, Marian Klinger, J. Radivojević, Chairat Shayakul, P. Fievet, Susumu Inaba, Masaaki Nakayama, Akira Noguchi, B. Athmani, T. Dimitrov, Emine Kocabaş, Phannee Pidetcha, P. Fardelone, Fumihiko Hinoshita, Raja I. Zabaneh, Hiroshi Nihei, M. Hattori, C. Raimondi, Naoko Yusa, Todd S. Ing, Hirofumi Makino, Manuel Martinez-Maldonado, Kouichi Hirayama, Björn Holmquist, Jesús Montoliu, P. Gilli, Hirokazu Okada, Hisashi Ozasa, Mitsuaki Kaizuka, Stefan H. Jacobson, Ichiro Koni, C. Aichberger, Augusto Antonello, David J. Leehey, R. Makdassi, A.F. van Lieburg, Masami Matsumura, Osamu Sakai, I. Pejčić, Toshio Okada, Yoshiaki Fujimiya, Miwako Arai, Hans Thysell, Seunghun Lee, Yu-Li Cho, V. Djordjević, David P. Brooks, Chul Woo Yang, Huan-Sheng Chen, Makoto Katagiri, Julio Ramos, William J. Kimberling, Kosuke Ota, Jackson Joe Yium, Paritosh Tiwari, M. Andréjak, Gary E. Striker, G. Pontoriero, P. Vaillant, Tung-Po Huang, Roberto Barrios, A. Peco-Antić, H. Sonnenberg, Osamu Hotta, Kaoru Sakai, Prida Malasit, Chie Inoue, Liliane J. Striker, Kandemir Tolga, Lorenzo A. Calò, Scott O. Trerotola, Stephen V. Foster, PeterMaria Rob, Salvatore Cantaro, Yoshihiko Kanno, V. Stojanov, Ann M. Johnson, A. Fournier, F. Zhang, Kosaku Nitta, Alex W. Yu, Richard Skroeder, P. Dennis DePalma, Keitaro Yokoyama, W. Proesmans, G. Guerra, Koji Kawamura, Merit F. Gadallah, M. Gowrishankar, I. Cheong, Eiko Suzuki, Klaus Sack, Maria Golato, Silvana Favaro, Byung Kee Kim, S. Di Filippo, J. Gondry, Necmi Aksaray, Akira Yamada, D. Marcelli, Nobuo Watanabe, Adam Bahattin, Makoto Uchiyama, Michihiro Gotoh, E. Sestigiani, Naoto Yamaguchi, Patricia A. Gabow, Stawomir C. Zmonarski, C. Campieri, Kenichi Shikata, Kennichi Shiroto, Steven Foster, I. Constant, Katsuhiko Sudo, A. Giudicissi, Ulf Nilsson, L. Neri, Kunimasa Yan, Regina R. Verani, Shuichi Tomisawa, Je Hoon Lee, M. Avramović, Akpolat Tekin, Chih-Wei Yang, Stanistaw Miękisz, Mercè Borràs, Haruki Nagahana, A. Koenigsrainer, Jerzy W. Mozrzymas, S. Stefoni, M.L. Halperin, Margret Arnadottir, Sigeko Hara, Naoyuki Tamura, Tsutomu Takahashi, Ikuo Horigome, Hidehiko Kawato, M. Ramdane, Yoshio Taguma, Yukiyoshi Nakamura, Chege J. Mukuria, F. Anaya, Satoshi Iwabuchi, Jana Pindur, L.M. Ho, M. Zompatori, Tetsuo Shibata, Ettore Tresca, V.V.A.M. Knoers, Touru Nishihara, L.A.H. Monnens, Ichiro Kajiwara, Akio Koyama, M. Crepaldi, Yoshindo Kawaguchi, Youji Ogawa, M.S. Garcia de Vinuesa, J.M. Hoarau, Shigeru Horita, Scott J. Savader, Wadi N. Suki, Bedir Abdülkerim, E. Lobjoie, Yuki Sakai, Hiroaki Muramoto, Andrzej Teisseyre, Han-Nan Liu, Tun-Jun Tsai, G. Bacchini, Hitoshi Ebata, Yung-Ming Chen, E. De Paoli Vitali, D. Toncheva, M. Kostić, Maria José Panadés, E. David, F. Valderrábano, Monica Rizzolo, Mario Liani, Yosuke Ogura, G.K. Richards, Catherine I. Lai, Angela D'Angelo, Nobuhide Mimura, Takao Saruta, Masaru Nasu, V. Bonomini, Neslihan Seyrek, Yoshio Suzuki, Somkiat Vasuvattakul, V. Parezanović, Theodore P. Labus, Masaharu Naiki, Shaul G. Massry, Yasuo Magari, S. Paydas, and Ryokichi Yasumori

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1996
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7. Contents, Vol. 10, 1990

Author

Shaul G. Massry, Gilbert Deray, Fumiaki Marumo, Gerald A. Young, Barbara F. Prowant, Michèle Dubois, Joel D. Kopple, Richard Bourbouze, F. Martinez, Roberta Bertelli, Corrine Algrim, Esteban Poch, Ronaldo R. Bergamo, Alejandro Darnell, Rosanna Gusmano, Carlos Quereda, J. Grellet, B. Baumelou, Maria Rosa Ciardi, Bertr Baumelou, Christy A. Price, Adalberto Sessa, Esa Soppi, C. Jacobs, Janet Dichiro, Larry A. Slomowitz, Fabrizio Ginevri, Jukka Mustonen, Joaquín Ortuño, Francis Hon-wai Wong, Mary Grosvenor, Albert Torras, Miguel González-Clemente, Mariana Linker-Israeli, Amedeo F. De Vecchi, Alek M. Brownjohn, Laura Torri Tarelli, Edward F. Vonesh, Claude Jacobs, Gary M. Rabetoy, Zbigniew Gaciong, Masayoshi Shichiri, Kiyohide Fushimi, Maite Rivera, Patricia Ho, Patrick Lau, John W.A. Findlay, Luis Revert, Mietta Meroni, Olavi Hällström, Amos Pasternack, J.-P. Rey, Jeffrey M. Sailstad, Jadwiga M. Alexiewicz, K. K. Pun, Hélène Beaufils, Marian Klinger, G. Deray, Thomas O. Pitts, Koichi Matsumoto, José, Alain Baumelou, Gian Marco Ghiggeri, Vinay Sakhuja, H. Boulechfar, Allen R. Nissenson, Kirpal S. Chugh, A. Botey, Claudia Castelnovo, Ana Gonzalo, Giovanni Candiano, Karl D. Nolph, and M.F. Bellin

Subjects
Gerontology, Nephrology, business.industry, Library science, Medicine, business
Published
1990
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8. Evidence of Impaired T Cell Function in Hemodialysis Patients: Potential Role for Secondary Hyperparathyroidism

Author

Thomas O. Pitts, Jadwiga M. Alexiewicz, Shaul G. Massry, Mariana Linker-Israeli, Marian Klinger, and Zbigniew Gaciong

Subjects
Adult, Male, medicine.medical_specialty, Resuscitation, T-Lymphocytes, T cell, medicine.medical_treatment, Parathyroid hormone, Lymphocyte Activation, Renal Dialysis, Internal medicine, Humans, Medicine, Phytohemagglutinins, Hyperparathyroidism, business.industry, Antibodies, Monoclonal, T lymphocyte, Middle Aged, medicine.disease, Endocrinology, medicine.anatomical_structure, Parathyroid Hormone, Nephrology, Impaired T cell function, Interleukin-2, Kidney Failure, Chronic, Calcium, Female, Hyperparathyroidism, Secondary, Secondary hyperparathyroidism, Hemodialysis, business, hormones, hormone substitutes, and hormone antagonists
Abstract

Previous studies in our laboratory showed that the T cell is a target for parathyroid hormone (PTH) action. It is theoretically possible, therefore, that chronic exposure of the T cells to high blood levels of PTH in patients with chronic renal failure may adversely affect T cell function. We examined in both normal subjects and dialysis patients several aspects of T cell function, including (1) T cell proliferation in response to phytohemagglutinin (PHA) mitogen with and without PTH and with and without exogenous interleukin 2 (IL-2); (2) the IL-2 production induced by PHA with and without PTH, and (3) resting levels of cytosolic calcium--[Ca2+]i--and the increment in [Ca2+]i in response to anti-CD3 antibody. Although PHA significantly (p less than 0.01) stimulated proliferation of T cells from both normal subjects and dialysis patients, the magnitude of the stimulation was significantly (p less than 0.01) smaller in the latter group. In both normal subjects and dialysis patients, exogenous IL-2 alone stimulated T cell proliferation, and the magnitude of the stimulation was similar to that produced by PHA. Also, IL-2 augmented PHA-induced proliferation of T cells from normal subjects, but failed to do so in T cells from dialysis patients. PHA did not augment IL-2 production by T cells from dialysis patients, and PTH did not correct this defect. The resting levels of [Ca2+]i in T cells from dialysis patients were significantly (p less than 0.01) higher, and the increments in [Ca2+]i in response to anti-CD3 antibody were significantly (p less than 0.01) lower than in T cells from normal subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1990
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9. Subject Index Vol. 72, 1996

Author

P. Fardelone, Naoko Yusa, Hirokazu Okada, J. Gondry, N. Seyrek, Hiroshi Mabuchi, D Di Landro, Michihiro Gotoh, Patricia A. Gabow, Per Kjellstrand, Ichiro Koni, Osamu Hotta, Naoyuki Tamura, Hiroshi Toma, Stephen V. Foster, Julio Ramos, V. Bonomini, M. Andréjak, Nilwarangkur S, Stawomir C. Zmonarski, Somkiat Vasuvattakul, Ikuo Horigome, Hidehiko Kawato, L. Raffaele, Toshio Okada, Satoshi Iwabuchi, Keitaro Yokoyama, Neslihan Seyrek, Masateru Kawabata, Yahya Sagliker, Seunghun Lee, Yung-Ming Chen, D. Toncheva, P. Finielz, Kennichi Shiroto, M. Zompatori, Yong Goo Kim, Masaaki Nakayama, M. Crepaldi, Yoshindo Kawaguchi, Yoshiharu Hiratsuka, L. Neri, I. Cheong, Eiko Suzuki, A. Michault, V. Dalmastri, R. Margreiter, Shinsuke Nomura, R. Makdassi, Maria Golato, Kosuke Ota, Scott J. Savader, R. Mallmann, Maria José Panadés, M.S. Garcia de Vinuesa, Hiroshi Osawa, Wadi N. Suki, Yoshiaki Fujimiya, M. Vedovato, T. Dimitrov, Sigeko Hara, Emine Kocabaş, Akpolat Tekin, M. Avramović, Der-Cherng Tarng, A. Giudicissi, Fumihiko Hinoshita, Chih-Wei Yang, Yoshio Suzuki, Regina R. Verani, H. Sonnenberg, Takao Kohsaka, Watanachai Susaengrat, Hiromichi Suzuki, F. Malacarne, Tsutomu Takahashi, Prida Malasit, Chie Inoue, Kandemir Tolga, Lorenzo A. Calò, F. Locatelli, Tun-Jun Tsai, Han-Nan Liu, Augusto Antonello, David J. Leehey, A. Fournier, Mercè Borràs, PeterMaria Rob, F. Zhang, F. Fabrizi, E. De Paoli Vitali, Masami Matsumura, Juan M. Gonzalez, Salih Hazar, J. Guiserix, Raja I. Zabaneh, M. Kostić, George Moustakas, Syunji Ishihara, Chul Woo Yang, B. Athmani, Salvatore Cantaro, Rainer Nobiling, D. Oefner, P. Gilli, Kogo Onodera, Chege J. Mukuria, Y. Sagliker, Vivette D. D'Agati, Shigeo Takebayashi, Hans-Georg Classen, Phannee Pidetcha, M. Hattori, G. Paunović, G.K. Richards, P. Dennis DePalma, Todd S. Ing, Catherine I. Lai, Angela D'Angelo, Hiroshi Kitamura, Zhi-Hong Liu, F. Anaya, Hisashi Ozasa, Mitsuaki Kaizuka, Byung Kee Bang, Christos Iatrou, V. Parezanović, Yoshiko Fujita, G.F. Romagnoli, Mario Liani, Makoto Katagiri, Theodore P. Labus, David P. Brooks, Majed Odeh, Masaru Nasu, Koji Kawamura, A. Peco-Antić, Tanekazu Harada, Kosaku Nitta, Nobuhide Mimura, Liliane J. Striker, I. Guarnori, Syuko Yamamoto, Gengo Osawa, Arturo Borsatti, Ann M. Johnson, Zensuke Ota, Filippo Salvati, Alex W. Yu, Hirofumi Makino, Takao Saruta, Richard Skroeder, Divyesh M. Bhatt, G. Ricci, Masaki Kobayashi, C. Raimondi, L.P.W.J. van den Heuvel, Akira Yamada, C. Aichberger, Young Ok Kim, Kamberi Perparim, Youji Ogawa, Chairat Shayakul, P. Fievet, Hikaru Sugimoto, Necmi Aksaray, D. Marcelli, Osamu Sakai, Ulf Nilsson, Huan-Sheng Chen, Shigeru Horita, Björn Holmquist, Naoto Yamaguchi, E. Lobjoie, Steven Foster, L. Perini, G. Guerra, M. Gowrishankar, Masaharu Naiki, Luan D. Truong, Ank Nurol, Haruki Nagahana, A.F. van Lieburg, Mohamed A. El-Shahawy, Merit F. Gadallah, Hiroshi Inuma, Kaoru Sakai, Kenichi Shikata, Shuichi Tomisawa, Je Hoon Lee, Ching-Huai Huang, Miwako Arai, S. Di Filippo, Stanistaw Miękisz, Constantinos A. Demopoulos, Kouichi Hirayama, R.F. Gagnon, Nobuo Watanabe, G. Pontoriero, Adam Bahattin, Roberto Barrios, P. Vaillant, Makoto Uchiyama, Hiroshi Ishida, Mark W. Majesky, A.G. Brox, G. Erba, Tung-Po Huang, E. Sestigiani, Tadashi Asami, Kunimasa Yan, R. Pérez-García, M. Ramdane, Yoshio Taguma, Yukiyoshi Nakamura, C. Campieri, Shaul G. Massry, Scott O. Trerotola, Satsuki Yamada, Yasuo Magari, Yoshihiko Kanno, S. Paydas, Jana Pindur, L.M. Ho, Peter Nilsson-Ehle, Smaragdi Antonopoulou, W. Proesmans, J. Radivojević, H.A. Jalil, Yu-Li Cho, Ettore Tresca, V.V.A.M. Knoers, Ryokichi Yasumori, J.P. Mallie, Jackson Joe Yium, Byung Kee Kim, Paritosh Tiwari, Kyoko Kurose, V. Stojanov, Hiroyoshi Matsukura, J.M. Hoarau, Silvana Favaro, Bedir Abdülkerim, Hitoshi Ebata, Yuki Sakai, Hiroaki Muramoto, Andrzej Teisseyre, G. Bacchini, Klaus Sack, E. David, I. Constant, F. Valderrábano, Monica Rizzolo, Katsuhiko Sudo, Yosuke Ogura, A. Koenigsrainer, Jerzy W. Mozrzymas, S. Stefoni, M.L. Halperin, Margret Arnadottir, M. Dapporto, Satoru Tsunoda, Arie Oliven, V. Djordjević, I. Pejčić, William J. Kimberling, Gary E. Striker, M. Oh, Shuichi Hatakeyama, Hideaki Yamabe, M. Lago, Akira Noguchi, Tetsuo Shibata, Saime Paydas, Hiroshi Nihei, Sumalee Nimmannit, G. Devulder, Marian Klinger, Susumu Inaba, Touru Nishihara, L.A.H. Monnens, Hans Thysell, V. Stefanović, J.C. Boulanger, Ichiro Kajiwara, Akio Koyama, Jesús Montoliu, Panos Ziroyiannis, Stefan H. Jacobson, Sompong Ong-ajyooth, Manuel Martinez-Maldonado, and B. de Cagny

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1996
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10. Subject Index Vol. 26, 2008

Author

P. Muñiz, Shamshad Zarina, Louise Nordfors, Danuta Zwolińska, Kyungsoo Lee, Yung-Wei Chen, Kwan-Dun Wu, Ulrich Saueressig, Abdul Rashid Qureshi, Bernabé Jurado-Gámez, Jacek Kleszczyński, Michał Chmielewski, Mariusz Kusztal, Irena Makulska, Ming-Shiou Wu, Andrés Cosano Povedano, Gianni Celsi, Pedro Aljama, Tzong-Shinn Chu, Olof Heimbürger, Marian Klinger, Peter Stenvinkel, Tao Wang, Ylva Tranæus Lindblad, Jonathan T.C. Kwan, Wen-Yi Li, Luis Muñoz-Cabrera, Juan Jesus Carrero, Chih-Chung Shiao, Byoung Goo Min, G. Torres, Erwin De Cock, Alberto Canepa, Wacław Weyde, P. Abaigar, Theres Jägerbrink, Yong Soon Won, Karin Luttropp, Fu-Chang Hu, Alba Carrea, Tomasz Porażko, Magdalena Krajewska, Qian Lu, Mohammed E. Suliman, Tomasz Gołębiowski, B. González-Diez, Hans Jörnvall, Vin-Cent Wu, Claudine Sapède, Bengt Lindholm, Andrew Davenport, Yu-Feng Lin, Lei Cheng, Cho Hae Mun, Alberto Rodríguez-Benot, Jawed Shafqat, Wen-Je Ko, Peter Bárány, Sa Ram Lee, Uzma Naseeb, Yih-Sharng Chen, Anders Alvestrand, Yung-Ming Chen, Jonas Axelsson, Alejandro Martin-Malo, M. Cavia, and Tao-Min Huang

Subjects
Index (economics), Nephrology, Statistics, Subject (documents), Hematology, General Medicine, Mathematics
Published
2008
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11. PSN Society News

Author

Omar Noel Medina-Campos, Aneta Małyska, Dana Lixandru, Emam Waked, Carmen Barbulescu, Marian Klinger, Małgorzata Kubik, Beata Strempska, Beata Czerwienska, Malak Nabil, Satz Mengensatzproduktion, Mojmír Kasalický, Dorota Jędrzejka, Joo Yeon Lee, Jerzy Chudek, Branislav Štrauch, Martin Mašek, Yun-Mi Song, José Pedraza-Chaverri, Druck Reinhardt Druck Basel, Sang Cheol Lee, Krzysztof Letachowicz, Zaida Noemy Cabrera Jimenez, David Michalský, Omnia El-Bendary, João Egidio Romão, Elvira Rus, Edilia Tapia, Wioletta Dziubek, Marian Danilewicz, Ján Rosa, Virgilia Soto, Jana Vlková, Laura G. Sánchez-Lozada, Małgorzata Wągrowska-Danilewicz, Michał Nowicki, Ildikó Seres, Emad Abdallah, Shao-wu Shu, Kayoung Lee, Irina Stoian, Joohon Sung, Andreas Kribben, Sheng-ping Chao, Magdalena Krajewska, Cristina Capusa, Michael von Ostrowski, Isac de Castro, Gabriel Mircescu, Andrés M. Manrique, Rosilene M. Elias, Tomasz Gołębiowski, Mingming Zhao, José Santamaría, Tomáš Zelinka, Ferenc Sztanek, Shi-xi Xiong, Jiří Widimský, Péter Koncsos, Ilona Kurnatowska, Jana Dvořáková, Mariusz Kusztal, Rodrigo Bueno de Oliveira, Marek Woźniewski, Andrzej Wiecek, Katarzyna Madziarska, Bernardo Rodriguez-Iturbe, Éva Varga, Marcin Adamczak, István Kárpáti, Hai-rong Wang, Youn Sic Kim, Benedito Pereira, Wacław Weyde, Robert Holaj, Carmen Avila-Casado, Magdalena Cristóbal, Martha Franco, Seung Woo Park, Karla M. Ortiz-Vega, Magdalena Szotowska, De-liang Chen, Ondřej Petrák, Xue-dong Gan, Stefan Herget-Rosenthal, Mariann Harangi, Jian-lei Cao, and György Paragh

Subjects
Nephrology, business.industry, Media studies, Medicine, Physiology, General Medicine, Cardiology and Cardiovascular Medicine, business
Published
2011
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12. Subject Index, Vol. 10, 1990

Author

Gilbert Deray, J. Grellet, Michèle Dubois, Barbara F. Prowant, Hélène Beaufils, J.-P. Rey, Karl D. Nolph, Jadwiga M. Alexiewicz, Masayoshi Shichiri, Patricia Ho, Mietta Meroni, M.F. Bellin, Claude Jacobs, Kiyohide Fushimi, Alain Baumelou, Amos Pasternack, Ronaldo R. Bergamo, Mariana Linker-Israeli, Laura Torri Tarelli, Rosanna Gusmano, Edward F. Vonesh, O. Hällström, Gary M. Rabetoy, Esteban Poch, Gian Marco Ghiggeri, Luis Revert, Jeffrey M. Sailstad, Fabrizio Ginevri, Carlos Quereda, K. K. Pun, Maria Rosa Ciardi, Mary Grosvenor, Bertr Baumelou, Alek M. Brownjohn, Christy A. Price, E. Soppi, Thomas O. Pitts, Francis Hon-wai Wong, José, Richard Bourbouze, Miguel González-Clemente, Patrick Lau, Alejandro Darnell, John W.A. Findlay, Kirpal S. Chugh, Jukka Mustonen, Shaul G. Massry, H. Boulechfar, Marian Klinger, Allen R. Nissenson, Claudia Castelnovo, Fumiaki Marumo, Gerald A. Young, Albert Botey, Ana Gonzalo, Vinay Sakhuja, Giovanni Candiano, G. Deray, Joel D. Kopple, F. Martinez, Maite Rivera, Koichi Matsumoto, Corrine Algrim, Roberta Bertelli, Zbigniew Gaciong, B. Baumelou, Adalberto Sessa, Albert Torras, C. Jacobs, Janet Dichiro, Larry A. Slomowitz, Joaquín Ortuño, and Amedeo F. De Vecchi

Subjects
Gerontology, Index (economics), Nephrology, business.industry, Medicine, Subject (documents), business
Published
1990
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