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2. Idiopathic CD4+ Lymphocytopenia May Be due to Decreased Bone Marrow Clonogenic Capability

Author

Maria Caterina Sirianni, Antonella Isgrò, Claudia Gramiccioni, Ivano Mezzaroma, Fernando Aiuti, and Alessandra Fantauzzi

Subjects
Adult, Male, cd4+ lymphocytopenia, T cell, Immunology, CD34, CD38, Biology, stem cells, Bone Marrow, medicine, Humans, Immunology and Allergy, Progenitor cell, bone marrow, idiopathic, cd4+lymphocytopenia, cytokines, T-Lymphocytopenia, Idiopathic CD4-Positive, Interleukin-7, General Medicine, Middle Aged, medicine.disease, Haematopoiesis, medicine.anatomical_structure, Female, Bone marrow, Stem cell, Lymphocytopenia
Abstract

Background: Idiopathic CD4+ lymphocytopenia is defined by a stable decrease of CD4+ T cells in the absence of any known cause of immune deficiency. The mechanisms responsible for the immunological impairment are still unknown, but a regenerative failure of hematopoietic stem/progenitor cells has been hypothesized. Methods: We evaluated in the bone marrow (BM) of 5 patients with idiopathic CD4+ lymphocytopenia the phenotype of BM progenitor cells, their differentiation capacity with colony-forming cells and long-term culture-initiating cell assays, in parallel with the spontaneous IL-7 production in the patient sera. Results: Compared with controls, a regenerative failure of hematopoietic stem cells has been observed, both in ‘committed’ and in ‘uncommitted’ progenitor cells, despite high IL-7 serum levels. The percentage of phenotypically primitive CD34+CD38–DR+ cells (this includes the lymphoid precursor cells) was decreased, suggesting an involvement of the more primitive BM compartment in the de novo T cell generation. Conclusions: Despite the low number of patients, due to the low incidence of the disease, the decrease of primitive precursors sustains the possibility that diminished stem cell precursors might contribute to the development of CD4+ T cell depletion.

Published
2005
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3. Contents Vol. 136, 2005

Author

Claudia Gramiccioni, Yayoi Mizokami, Erliyani Sartono, L. Hummelshoj, Shigehiko Mizutani, Rudolf Valenta, Ronald van Ree, Sitti Wahyuni, Hiroyuki Nakamura, Fernando Aiuti, Jabbar S. Ahmed, Y.T. Kim, K.H. Kim, Yoshitaka Ohkubo, Albrecht Bufe, Akio Kawamura, L.K. Poulsen, A.M. Ejrnaes, Ines Swoboda, Tomohiko Endo, Jaring S. van der Zee, S. Cho, Kirsten Gehlhar, Bernhard F. Gibbs, Seitaro Mutoh, Hiroaki Kajiyama, Birgit Kullmann, Marcus Peters, Kiyosumi Shibata, H.H. Jacobi, H.Y. Park, Yoshihiko Morishita, E. Tsiompanou, Helmut H. Wolff, Kenji Tabata, Monika Grote, Ivano Mezzaroma, Yutaka Motohashi, Alessandra Fantauzzi, Antonella Isgrò, Jürgen Grabbe, S.W. Cho, Fumitaka Kikkawa, Kirsten Brockmann, Arnd Petersen, G.M. Boxer, U. Bodtger, R. Watson, Yoshitaka Hirayama, M. Svenson, Andarias Mangali, Maria Caterina Sirianni, Kazuhiko Ino, Seiji Nomura, J.S. Kim, Rudolf Reichelt, Holm Bussler, Detlef Zillikens, Taniawati Supali, J.S. Lee, Kikuo Miyayasu, Yoshihiro Kaneko, Ulrike Seitzer, Fu-Tong Liu, Maria Yazdanbakhsh, T. Levine, K.H. Joo, Akira Eboshida, Jeanine J. Houwing-Duistermaat, Hans van Schijndel, Wolf-Meinhard Becker, and R.H.J. Begent

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
2005
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4. Subject Index Vol. 136, 2005

Author

U. Bodtger, Bernhard F. Gibbs, S.W. Cho, Yoshihiro Kaneko, Kazuhiko Ino, Seiji Nomura, Birgit Kullmann, H.Y. Park, Marcus Peters, K.H. Kim, Ines Swoboda, Tomohiko Endo, Erliyani Sartono, Holm Bussler, Jürgen Grabbe, Claudia Gramiccioni, Yoshitaka Ohkubo, Fernando Aiuti, Fu-Tong Liu, Y.T. Kim, Maria Yazdanbakhsh, Detlef Zillikens, Ronald van Ree, Shigehiko Mizutani, Rudolf Valenta, Akio Kawamura, Ulrike Seitzer, L. Hummelshoj, G.M. Boxer, Akira Eboshida, Sitti Wahyuni, H.H. Jacobi, L.K. Poulsen, R.H.J. Begent, Hiroyuki Nakamura, Jaring S. van der Zee, Jabbar S. Ahmed, Ivano Mezzaroma, Yoshihiko Morishita, M. Svenson, Monika Grote, Yutaka Motohashi, Jeanine J. Houwing-Duistermaat, K.H. Joo, Kikuo Miyayasu, Yayoi Mizokami, J.S. Kim, Rudolf Reichelt, Hans van Schijndel, Antonella Isgrò, Albrecht Bufe, Maria Caterina Sirianni, Kiyosumi Shibata, R. Watson, Kenji Tabata, Helmut H. Wolff, Yoshitaka Hirayama, Andarias Mangali, Seitaro Mutoh, Fumitaka Kikkawa, Arnd Petersen, Alessandra Fantauzzi, T. Levine, E. Tsiompanou, Wolf-Meinhard Becker, Kirsten Brockmann, A.M. Ejrnaes, Hiroaki Kajiyama, Kirsten Gehlhar, S. Cho, Taniawati Supali, and J.S. Lee

Subjects
Index (economics), Immunology, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
2005
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