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1. Contents Vol. 152, 2010

Author

Hasan Yuksel, En-Chih Liao, Marc A. Riedl, Hirokazu Mizoguchi, Daniel Teschner, Riccardo Asero, Ajax Mercês Atta, Ulrike Körmöczi, Gen Tamura, Yuichi Ohkawara, Alberto Tedeschi, A. Martínez, Kaoru Kusama, Isao Ohno, Kyoko Futamura, Nozomu Ogihara, Massimo Cugno, Peter Steinberger, Erina Lin, İsmail Reisli, Akira Fukumoto, Winfried F. Pickl, Shuhei Fukuda, Yasushi Tomita, Motoaki Takayanagi, Esther von Stebut, Konosuke Omori, Arno Rottal, Kana Wada, Tomoko Nagai, Hirohisa Saito, I. Ibarrola, Shinobu Sakurada, Susetta Finotto, Manabu Nonaka, Manuel Sanchez-Solis, Fernanda Garcia Guerra, Mariana Menezes Pereira, Kaori Okuyama, Kenji Matsumoto, Chiharu Tabata, Mittermayer Barreto Santiago, Klaus G. Schmetterer, Fulya Tahan, Joachim H. Maxeiner, Ahmet Akcay, Yakup Canitez, Ozge Yilmaz, Toshiaki Yagi, Ömer Cevit, Fazil Orhan, Atsuko Sakanushi, Hironori Sagara, J.A. Asturias, Luis Garcia-Marcos, Hiroshi Komatsu, Kanami Orihara, M.C. Arilla, Ruby Pawankar, Sebastian Reuter, Chau-Mei Ho, Markus G. Seidel, Virginia Pérez-Fernández, Rie Tabata, Stephanie Dinges, Ichiro Sora, Maria Sanchez-Bahillo, Noriko Hashimoto, Hideaki Morita, Aysen Bingol Boz, Peri Caucig, Antonia Elena Martinez-Torres, Susanne Matthes-Martin, Nevin Uzuner, Martin D. Chapman, S. Brena, Andrew Saxon, Klaus Schwarz, Christian Taube, Semanur Kuyucu, Maria Luiza B. Sousa Atta, Chrystelle Colas, Demet Can, Jaw-Ji Tsai, and Akio Matsuda

Subjects
Immunology, Immunology and Allergy, General Medicine, Biology
Published
2010

2. β2-Adrenoceptor Agonists Enhance Cytokine-Induced Release of Thymic Stromal Lymphopoietin by Lung Tissue Cells

Author

Shuhei Fukuda, Yasushi Tomita, Hironori Sagara, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto, Noriko Hashimoto, Kyoko Futamura, Kanami Orihara, and Hideaki Morita

Subjects
Agonist, Thymic stromal lymphopoietin, Lung, business.industry, medicine.drug_class, medicine.medical_treatment, Immunology, Cell, General Medicine, medicine.disease, respiratory tract diseases, Cytokine, medicine.anatomical_structure, Stroma, medicine, Immunology and Allergy, Respiratory system, business, Asthma
Abstract

Background: Whileβ2-adrenoceptor agonists (β2-agonists) are widely used as bronchodilators in the treatment of asthma, there has been increasing concern that regular use of β2-agonists may adversely affect the control of asthma. However, the molecular mechanisms of such undesirable effects of β2-agonists are not fully understood. In this study, we examined the effects of β2-agonists on cytokine-induced production of thymic stromal lymphopoietin (TSLP), an indispensable cytokine in the development of allergic diseases, by lung tissue cells. Methods: Normal human bronchial epithelial cells (NHBE), smooth muscle cells (BSMC) and fibroblasts (NHLF) were stimulated with the IL-4 and TNF-α cytokines, alone and in combination, and their production of TSLP was examined by ELISA. The effects of β2-agonists (salmeterol, formoterol, salbutamol), intracellular cyclic adenosine monophosphate (cAMP)-elevating agents (8-bromo-cAMP, dibutyryl cAMP, forskolin) and a corticosteroid (fluticasone) on the cytokine-induced TSLP production were examined. Results: The following results were observed in all three types of lung tissue cells tested (that is, NHBE, BSMC and NHLF). Costimulation with IL-4 and TNF-α significantly induced TSLP production, and β2-agonists further enhanced it via upregulation of intracellular cAMP. However, addition of a corticosteroid to the cytokines and β2-agonist resulted in a marked decrease in TSLP production. Conclusions: β2-Agonists significantly enhanced the cytokine-induced TSLP production by primary human lung tissue cells. This may be partly responsible for the undesirable clinical effects of continuous β2-agonist monotherapy, and combination therapy with a corticosteroid might effectively inhibit TSLP-mediated allergic inflammation.

Published
2010

3. Subject Index Vol. 152, 2010

Author

Hasan Yuksel, Atsuko Sakanushi, Erina Lin, Yakup Canitez, Ozge Yilmaz, Hirokazu Mizoguchi, Hiroshi Komatsu, Nevin Uzuner, Isao Ohno, Aysen Bingol Boz, Chiharu Tabata, Virginia Pérez-Fernández, Rie Tabata, Hironori Sagara, J.A. Asturias, Shuhei Fukuda, Peri Caucig, Demet Can, Motoaki Takayanagi, Jaw-Ji Tsai, Toshiaki Yagi, Hirohisa Saito, Maria Sanchez-Bahillo, Antonia Elena Martinez-Torres, Nozomu Ogihara, Manuel Sanchez-Solis, Mittermayer Barreto Santiago, Shinobu Sakurada, Kaoru Kusama, Akio Matsuda, Hideaki Morita, Chau-Mei Ho, Marc A. Riedl, Susanne Matthes-Martin, Akira Fukumoto, Yuichi Ohkawara, Stephanie Dinges, A. Martínez, Kyoko Futamura, En-Chih Liao, Ichiro Sora, Ajax Mercês Atta, Martin D. Chapman, S. Brena, Noriko Hashimoto, Kanami Orihara, Ahmet Akcay, M.C. Arilla, Peter Steinberger, Andrew Saxon, Winfried F. Pickl, Alberto Tedeschi, Tomoko Nagai, Klaus Schwarz, Fazil Orhan, I. Ibarrola, Mariana Menezes Pereira, Fernanda Garcia Guerra, Daniel Teschner, Susetta Finotto, Christian Taube, Massimo Cugno, Semanur Kuyucu, Klaus G. Schmetterer, Kaori Okuyama, Fulya Tahan, Ulrike Körmöczi, Ömer Cevit, Ruby Pawankar, İsmail Reisli, Markus G. Seidel, Maria Luiza B. Sousa Atta, Chrystelle Colas, Konosuke Omori, Kana Wada, Joachim H. Maxeiner, Esther von Stebut, Manabu Nonaka, Sebastian Reuter, Riccardo Asero, Kenji Matsumoto, Gen Tamura, Luis Garcia-Marcos, Yasushi Tomita, and Arno Rottal

Subjects
Index (economics), Immunology, Statistics, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
2010

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