1. Long-Term Effects of Alogliptin Benzoate in Hemodialysis Patients with Diabetes: A 2-year Study
- Author
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Kiichiro Fujita, Yoshikazu Goto, Hiromichi Gotoh, Masahiro Inagaki, Tatsuo Shimizu, Michiyasu Inoue, Yuya Nakamura, and Katsuji Oguchi
- Subjects
Male ,medicine.medical_specialty ,Drug-Related Side Effects and Adverse Reactions ,medicine.medical_treatment ,Treatment outcome ,MEDLINE ,Alogliptin Benzoate ,Comorbidity ,Type 2 diabetes ,Japan ,Piperidines ,Renal Dialysis ,Internal medicine ,Diabetes mellitus ,Prevalence ,Humans ,Hypoglycemic Agents ,Medicine ,Longitudinal Studies ,Renal Insufficiency, Chronic ,Uracil ,Intensive care medicine ,Dipeptidyl-Peptidase IV Inhibitors ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Clinical trial ,Treatment Outcome ,Diabetes Mellitus, Type 2 ,Nephrology ,Female ,Hemodialysis ,business - Abstract
Aim: To evaluate the long-term efficacy of monotherapy with the dipeptidase-4 inhibitor alogliptin benzoate in hemodialysis (HD) patients with type 2 diabetes. Methods: Sixteen diabetic HD patients with inadequate glycemic control (hemoglobin A1c (HbA1c) level >6.5% and glycated albumin (GA) level >20%) on diet and exercise participated in the study. No patients were taking other oral antidiabetic drugs or receiving insulin therapy. Alogliptin 6.25 mg was administered to patients once daily. HbA1c, GA levels were obtained before and after 2 years of treatment. Body weight and active glucagon-like peptide-1, blood glucose, insulin, C-peptide immunoreactivity, glucagon, albumin, hemoglobin, and total cholesterol levels were also examined before and after treatment. Results: Both HbA1c and GA levels decreased after starting alogliptin administration. As compared to the pretreatment levels, HbA1c and GA levels significantly decreased at 3 and 18 months, respectively, after starting alogliptin administration. HbA1c and GA levels decreased from 7.1 ± 0.2 to 5.8 ± 1.6% and from 22.5 ± 0.7 to 19.6 ± 0.6%, respectively, 24 months after beginning treatment. Glucagon-like peptide-1 levels (8.9 ± 5.7 pmol/l before treatment) doubled after treatment. Body weight and blood glucose, insulin, C-peptide immunoreactivity, glucagon, albumin, hemoglobin, and total cholesterol levels did not change with treatment. Only one significant adverse effect, a drug-related rash, was seen in 1 patient. Conclusion: Long-term (2-year) effects of alogliptin benzoate monotherapy suggest its efficacy as a new treatment strategy in diabetic HD patients.
- Published
- 2013
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