1. Increased Postnatal Inflammation in Mechanically Ventilated Preterm Infants Born to Mothers with Early-Onset Preeclampsia
- Author
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Irmeli Nupponen, Hannele Laivuori, Eero Kajantie, Sture Andersson, Heikki Repo, Sanna Siitonen, and R Turunen
- Subjects
Adult ,medicine.medical_specialty ,Neutrophils ,Birth weight ,Gestational Age ,Inflammation ,Monocytes ,Preeclampsia ,Leukocyte Count ,Obstetric Labor, Premature ,Pre-Eclampsia ,Pregnancy ,medicine ,Birth Weight ,Humans ,reproductive and urinary physiology ,Phagocytes ,Respiratory Distress Syndrome, Newborn ,CD11b Antigen ,Respiratory distress ,biology ,business.industry ,Obstetrics ,Early onset preeclampsia ,C-reactive protein ,Infant, Newborn ,Gestational age ,medicine.disease ,Respiration, Artificial ,female genital diseases and pregnancy complications ,Fetal Diseases ,C-Reactive Protein ,Pediatrics, Perinatology and Child Health ,biology.protein ,Premature Birth ,Female ,medicine.symptom ,business ,Infant, Premature ,Developmental Biology - Abstract
Background: Preeclampsia and preterm labor often underlie preterm birth, and are associated with maternal inflammation. In preterm infants, respiratory distress syndrome (RDS) and mechanical ventilation are associated with systemic inflammation. Objective: We aimed to study whether early-onset preeclampsia or preterm labor modulate the systemic inflammation affecting preterm infants with RDS. Methods: We recruited mechanically ventilated infants with gestational ages Results: As compared with infants born after preterm labor, infants born after early-onset preeclampsia had higher CD11b expression on days 1–6 on both neutrophils and monocytes. In addition, infants born after early-onset preeclampsia had higher CRP concentrations on days 2–6 (all p < 0.05). Conclusions: As compared with infants born after preterm labor to mothers without preeclampsia, infants born after early-onset preeclampsia presented with a stronger postnatal systemic inflammatory reaction. Antenatal exposure to preeclampsia may induce fetal leukocyte priming and regulation of inflammation, and thereby modify postnatal inflammatory reactions and morbidity.
- Published
- 2011