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5. Unspecific Bronchial Reactivity to Carbachol in Healthy Subjects – Effect of Age and Smoking Habits

Author

G Schultze-Werninghaus, R Buhl, R Siekmeier, and H Kronenberger

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Spirometry, Vital capacity, Functional Residual Capacity, Bronchoconstriction, Physiology, Maximal Midexpiratory Flow Rate, Bronchial Provocation Tests, Pulmonary function testing, Airway resistance, Functional residual capacity, Forced Expiratory Volume, medicine, Humans, Lung volumes, medicine.diagnostic_test, Inhalation, business.industry, Airway Resistance, Smoking, Total Lung Capacity, Respiratory disease, Age Factors, Middle Aged, medicine.disease, Case-Control Studies, Anesthesia, Carbachol, Female, Bronchial Hyperreactivity, business, Inspiratory Capacity
Abstract

Chronic inflammatory processes of the airways induced by long-time cigarette consumption are a crucial factor in the pathogenesis of chronic obstructive pulmonary disease. In contrast, the role of cigarette smoking in the pathogenesis of bronchial hyperreactivity (BHR) is still unclear. The aim of this study was to assess the effect of chronic cigarette consumption on pulmonary function tests and BHR in healthy subjects. 63 healthy smokers and 63 lifetime nonsmokers matched for sex, age, height and weight were evaluated. Pulmonary function was determined by body plethysmography and spirometry. Bronchial provocation was performed by inhalation of increasing doses of carbachol (up to 25 g/l) in isotonic NaCl solution. Pulmonary function tests were within normal limits in all subjects. Nevertheless, midexpiratory flow at 25% of forced vital capacity was significantly smaller, and functional residual capacity was significantly greater in middle-aged smokers (age: 40-60 years) compared to middle-aged nonsmokers (p0.05, both comparisons). In young smokers and nonsmokers (age: 20-30 years) pulmonary function tests were not different (p0.28, all comparisons). Importantly, the carbachol concentration that provoked a 50% rise in specific airway resistance (PD50sRaw) was similar in smokers and nonsmokers of both age groups (p0.05, both comparisons) and did not correlate with the age of the subjects (p0.2). No correlations between baseline values of pulmonary function tests and PD50sRaw were observed (p0.34, all comparisons). The observations confirm that the distribution profile of BHR is unimodal and apparently not affected by age and smoking habits.

Published
1994
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6. Contents, Vol. 94, 1991

Author

Graham S. LeGros, Hiroshi Yamakawa, K. Takatsu, Ratko Djukanovic, P.G. Holt, J. Bujanowski-Weber, P. Oehme, S. Bianchj, William Roche, I. Knöller, G. Delespesse, Toru Ando, Reinhold Penner, D. Macchia, R. Djukanovic, George W. Ward, Thomas Bieber, T. Furitsu, Makoto Dohi, Susan M. MacDonald, Martin D. Chapman, F. Chavarria, R. Robert Schellenberg, Michiko Haida, Makoto Nogami, John R. Brashler, J. Brom, Pascal Chanez, A. Ciccarelli, T.D. Whalley, M.J. Carmona, E. Saito, Mamoru Ito, H. Behrendt, W. Zachgo, Gabriele Zwadlo-Klarwasser, Philip J. Thompson, Sylvia Miescher, N.P. Siemensma, A. de Paulis, G. Schultze-Werninghaus, J.-P. Kinet, B.D. Gomperts, Takeo Juji, Ikuo Akutsu, Richard J. Simpson, S. Wilson, T.H. Lee, Suhad El-Lati, Bernhard Przybilla, J. Oliver, Sesha Reddigari, Monique Vogel, Koki Takahashi, Thomas Iff, L. Mugnai, E. Neher, Nathalie Paul-Eugène, Ph. Lassalle, Takeshi Fukuda, Dean D. Metcalfe, V. Lagente, C.E. O’Neil, Go Matsuzaki, C. McMenamin, Jordan N. Fink, G. Burow, Ch. Lemmermann, Ch. Schweiger, H. Wagner, K. Kurihara, D.R. Springall, Karin Pettenburger, A. Capron, H.Y.A. Lau, R. Wahl, G.J. Gleich, K. Rother, Shigeru Takafuji, W.R. Roche, Kurt Blaser, F. Gambassi, A. Pistelli, M. Bubak, Andrew F. Walls, Jeffrey M. Drazen, S.J. Lane, Johann-Christian Virchow, Akio Mori, J.M. Polak, Dietrich Kraft, Hans L. Spiegelberg, L. Lipponer, Friederike von zur Mühlen, R. zur Strassen, Rihoux Jean-Pierre, Susanne Spitzauer, Werner J. Pichler, Karen Britten, M. Schon-Hegrad, Barbara K. Stout, John Wilson, Hirokazu Okudaira, Otto Scheiner, Mitsuko Kondo, Akira Ishii, Richard Sporik, Daniel Weinreich, M. Keating, W. Dorsch, Manel Jordana, Ch.H. Heusser, Ingrid Enander, Massimo Triggiani, T. Ishizaka, Colin J. Sanderson, Dieter Vieluf, Stephanie A. Shore, J. Anrather, S. Terrados, Claus Bachert, Rosa M. Ten, E.W. Rauterberg, E. Masini, H. Rumpold, Jean Yves Lacoste, T.H.W. Lillie, K. Ohno, Alison M. Campbell, E. Gutierrez, F.L. Pearce, Stephan C. Bischoff, R. Suau, Miguel Blanca, P.H. Howarth, P.K. Jeffery, Robert L. Barker, E. Perez, M. Pfenning, Marshall Plaut, Piotr Kuna, T. Abe, H. Rotermund, Michael A. Lett-Brown, Herbert G. Johnson, Thomas Brunner, C. Ra, U. Ganzer, N. Hyslop, Kazuhiko Akiyoshi, Alain L. de Weck, J. Bews, A. Hartnell, J. Dry, K. Nosbüsch, Rafeul Alam, G. Le Gros, V. Brinkmann, Jacqueline M. Langdon, B. Thomas, P. Heap, Corinne Petit-Frère, A.G. Fernández, Wolfgang Schmutzler, Gianni Marone, Matsunobu Suko, R.W. Gristwood, D. Kraft, G.M. Walsh, A.G. Palma-Carlos, B. Bradley, N.S. Sakaguchi, J.M. Vega, O.-H. Wilhelms, R. Wiewrodt, A. Brini, Stephen R. Durham, M. Lupini, M.A. Reed, Thierry Maisonnet, A. Witzel, Peter J. Barnes, Ch. Brander, Lawrence M. Lichtenstein, A. Koffer, Y. Delneste, Laura Palma-Carlos, Jennifer Cairns, T. Brunnee, Elliott Homer, Diana J. Quint, F. Bettens, Monique Capron, Sohei Makino, Luanda Beck, T. Imai, Takayuki Ohtoshi, A. Akasawa, Lore Koller, Yoji Iikura, Naohiro Watanabe, Ahuva Nissim, J.W. Coleman, A. Ohgimi, D. Befus, J.R. Wilkinson, H. Küster, T. Katsunuma, Ch. Ebner, K.J. Turner, M.P. Piccinni, F. Ledermann, Michael Breitenbach, Bradley J. Undem, A.B. Kay, John E. Salvaggio, Carvalho de Sousa, S.T. Holgate, B. Girn, P. Berga, S. Bent, Gerald J. Gleich, Arnold S. Kirshenbaum, P.B. Boulos, Yoshitaka Ino, M. Breitenbach, R. Rathsack, May Azzawi, Sun Ying, Philippe Godard, J.H. Widdicombe, Rudolf Valenta, Christopher Corrigan, S. Romagnani, D.M. Kemeny, Bernard Dugas, Samuel B. Lehrer, Y. Churcher, John Gordon, C. Brom, F. Leynadier, Gert Kunkel, Gerard Cox, B.F. Weber, D. Diaz-Sanchez, Shinji Motojima, J.W. Wilson, Pieter L.B. Bruijnzeel, P.F. Mannaioni, K. Britten, Allen P. Kaplan, Yutaka Morita, K. Ishida, Erika Jensen-Jarolim, Jack Gauldie, Fiona R. Lake, S. Raspanti, Andrew Grant, R. Fadel, S. Dunnette, Jean Bousquet, Ivan Aebischer, Thomas A.E. Platts-Mills, T. Wyss, Richard D. O’Connor, Larry D. Ward, A.G. Morris, Clemens A. Dahinden, Toshifumi Yuuki, P. Parronchi, Hiroyuki Mochizuki, Gail M. McNutt, D.C. Reason, Martin Krieger, Lawrence E. Gelber, Naoki Inagaki, E. Kilchherr, Elisabeth Boichot, Qiu Gang, F. Gabl, Alec H. Sehon, J.V. Collins, Shiro Kasuya, J. Blomgren, Bernadette Pignol, Motohiro Ebisawa, N. Sakaguchi, Jacalyn H. Pierce, U. Blank, Fu-Tong Liu, Robert A. Seder, R. Hilger, Richard P. Bransford, M. Linssen, Jörg Kleine-Tebbe, P.D. Pare, Kazuhiko Yamamoto, Jean Michel Mencia-Huerta, Michael K. Bach, Pierre Braquet, J. Salvaggio, Reuben J.M. Falkoff, R. Merget, J. Hards, B.J. Holt, D. Strickland, P.E.R. Tatham, A.B. Tonnel, H. Saito, François-B. Michel, K. Akimoto, Jerry Dolovich, Brian M. Greenlee, Carl G. A. Persson, Anne Kagey-Sobotka, Tim R. Mosmann, Zelig Eshhar, N. Wallen, Maria Baeza, A.J. Wardlaw, Peter H. Howarth, Robin N. Poston, W. König, R.C. Benyon, M. Lopez, D. Mijic, E. Jarolim, William E. Paul, John P. Caulfield, B. Kunz, Milton A. Martins, Yasushi Okumura, J. Knöller, R. Ciriilo, K. Nieber, Geoffrey A. Stewart, Allen C. Myers, Zami Ben-Sasson, U. Hauser, M. G. Di Bello, Michael Duchêne, C. Baumgarten, C.J. Sanderson, Koji Ito, R. Valenta, M.-H. Jouvin, Menachem Rottem, F. Carswell, A. Miranda, K.R. Tainsh, Kimm J. Hamann, Judah A. Denburg, K. Wagner, Martin K. Church, Qutayba Hamid, O. Mejan, Johannes Ring, J. Fernandez, L. Juhlin, Kiyoshi Takatsu, Martin E. Sanders, Peter W. Heymann, C.E. Reed, P. Wentz-Murtha, Fred D. Finkelman, J. Llupiá, Helmut Rumpold, Stephen T. Holgate, Conceição B. Santos, G.M. Hänsch, W.L. Liu, Christoph Walker, M. Ricci, Ph. Gosset, E. Maggi, J. Wilson, R. Moqbel, and Beda M. Stadler

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1991
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7. Contents, Vol. 92, 1990

Author

W. König, B.A. Baldo, J. Fraj, Véronique Pancré, Masako Watanabe, Shigeo Mori, Mariko Motoishi, R.D. Merget, Kunihiko Obata, Motohiro Kurosawa, André Capron, I. Davila, D. Hoelzer, B. De La Hoz, R. Rajaraman, Tadashi Horiuchi, O.G. Ottmann, T. Pfeil, Johannes Roth, Junko Nihei, Yoshimichi Okayama, J. Cuesta, G. Schultze-Werninghaus, U. Koch, Fumio Nambu, Akira Ishii, Suetsugu Mue, Mitsugu Omata, Boris Vargaftig, C. Vergara, J. Puyana, Terumasa Miyamoto, Patrícia M.R. e Silva, Claudia P. Pasquale, Tatsuhide Kunishita, R.J. Dearman, Masumi Endoh, Clemens Sorg, Junji Yagi, Setsuo Kobayashi, Masatoyo Nishizawa, Florine J. van Milligen, Claude Auriault, Kazuo Ohuchi, Keisuke Toyama, Yoshihiro Asano, Takeshi Tabira, S. Rajaraman, Martine Damonneville, Kristoffer Hellstrand, Ursula Malorny, Atsuhiro Sugidachi, A.B. Maurer, Johannes Gutwald, P.A. Botham, Takemasa Nakagawa, Renaud Louis, A. Fischer, Susumu Tsurufuji, Matthias Goebeler, Noriyasu Hirasawa, Tomio Tada, Svante Hermodsson, G. Seipelt, Maurice Radermecker, Marco A. Martins, A. Ganser, Thea M. Vroom, Renato S.B. Cordeiro, J.M. MacSween, Mami Shiota, D.G. Harle, J. Meier-Sydow, Rob C. Aalberse, and W. Zachgo

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1990
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8. Allergens of Horse Epithelium

Author

G. Schultze-Werninghaus, H. Bretting, D. Franke, Wahl R, and H.J. Maasch

Subjects
medicine.diagnostic_test, Isoelectric focusing, Radioallergosorbent test, Immunology, Albumin, General Medicine, Allergen extract, Immunoelectrophoresis, medicine.disease_cause, chemistry.chemical_compound, Allergen, chemistry, medicine, Immunology and Allergy, Sodium dodecyl sulfate, Polyacrylamide gel electrophoresis
Abstract

We investigated five horse epithelial allergen extracts prepared from different qualities of raw material by several biochemical and immunochemical methods. Horse serum albumin and horse serum were used to identify serum-related antigens. We found high similarities as well as marked differences between the extracts. There were strong differences in the protein contents, the protein patterns obtained by isoelectric focusing and sodium dodecyl sulfate polyacrylamide gel electrophoresis, the total allergenic activities obtained by radioallergosorbent test inhibition assays and the amounts and numbers of serum-related proteins. The patterns of dander-related allergens in crossed radioimmunoelectrophoresis were similar but showed partly strong differences in allergen concentrations. Allergen compositions determined by blotting methods showed only minor differences between the investigated epithelial extracts. It appears that some of the differences, e.g. the content of serum-related proteins, depend on the way the different raw materials are prepared. Because serum-related extract components are not considered as major allergens, their content should be low in horse epithelial allergen extracts. For this reason whole skin cannot be recommended as starting material for horse epithelium allergen extract preparation.

Published
1990
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9. Tribolium confusum (Confused Flour Beetle, Rice Flour Beetle) – An Occupational Allergen in Bakers: Demonstration of IgE Antibodies

Author

R. zur Strassen, Rolf Merget, R Wiewrodt, W. Zachgo, R. Wahl, H Rotermund, G. Schultze-Werninghaus, and G Burow

Subjects
Flour beetle, biology, digestive, oral, and skin physiology, fungi, Immunology, Confused flour beetle, Wheat flour, food and beverages, General Medicine, Immunoglobulin E, biology.organism_classification, Rice flour, medicine.disease_cause, Allergen, Botany, biology.protein, medicine, Immunology and Allergy, Occupational exposure, Food science
Abstract

Specific IgE to proteins from Tribolium confusum (TC), a flour beetle, was detected in 9/125 sera of subjects exposed to rye and wheat flour. TC RAST was not inhibited by Dermatophagoides pteronyssinus, rye or wheat flour. Immunoblot experiments showed specific binding to three proteins from adult TC or pupae, not present in rye or wheat flour. These findings suggest that TC might act as an occupational allergen in a proportion of bakers.

Published
1991
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10. Biographical Sketch of Dr. Alec H. Sehon

Author

Matsunobu Suko, R.W. Gristwood, A.G. Palma-Carlos, T.H.W. Lillie, K. Ohno, R. Wiewrodt, K. Nosbüsch, Jacqueline M. Langdon, A. Brini, Zelig Eshhar, E. Kilchherr, V. Lagente, C.E. O’Neil, T. Katsunuma, Jean Michel Mencia-Huerta, M. Lopez, Michael K. Bach, D. Mijic, E. Jarolim, F.L. Pearce, E. Perez, Beda M. Stadler, Pierre Braquet, E. Saito, Mamoru Ito, H. Behrendt, N. Wallen, Maria Baeza, A.J. Wardlaw, Ch. Lemmermann, Ch. Schweiger, Bernadette Pignol, A. de Paulis, J. Salvaggio, Reuben J.M. Falkoff, J. Hards, William E. Paul, B.J. Holt, P. Berga, R. Djukanovic, Philip J. Thompson, Sylvia Miescher, N.P. Siemensma, Graham S. LeGros, Hiroshi Yamakawa, Yoshitaka Ino, M. Breitenbach, D. Strickland, K. Wagner, Martin K. Church, B. Bradley, Gert Kunkel, Gerard Cox, John P. Caulfield, Milton A. Martins, Yasushi Okumura, Daniel Weinreich, C.E. Reed, M.A. Reed, Thierry Maisonnet, Sesha Reddigari, Monique Vogel, Philippe Godard, J.H. Widdicombe, Robert A. Seder, F. Gabl, Christopher Corrigan, S. Romagnani, J.V. Collins, Jacalyn H. Pierce, O. Mejan, J. Fernandez, Fred D. Finkelman, J. Llupiá, O.-H. Wilhelms, H. Saito, François-B. Michel, A. Witzel, Jean Bousquet, Ivan Aebischer, Lawrence E. Gelber, Naoki Inagaki, Fu-Tong Liu, Thomas A.E. Platts-Mills, T. Wyss, D.M. Kemeny, Elisabeth Boichot, T. Imai, Y. Delneste, Ch. Brander, Stephanie A. Shore, John R. Brashler, Wolfgang Schmutzler, Richard P. Bransford, Fiona R. Lake, Ingrid Enander, W. Zachgo, Gabriele Zwadlo-Klarwasser, S. Terrados, Jennifer Cairns, Rosa M. Ten, R.C. Benyon, J.W. Coleman, Bernard Dugas, Samuel B. Lehrer, Y. Churcher, Shiro Kasuya, Takayuki Ohtoshi, G. Le Gros, D. Diaz-Sanchez, A.B. Tonnel, J. Brom, Pascal Chanez, J. Blomgren, John Gordon, P. Heap, M. Linssen, Jörg Kleine-Tebbe, Manel Jordana, Ch.H. Heusser, K. Akimoto, Jerry Dolovich, T. Ishizaka, Ratko Djukanovic, I. Knöller, Thomas Bieber, Peter H. Howarth, Helmut Rumpold, H. Rumpold, Motohiro Ebisawa, Jean Yves Lacoste, Gianni Marone, P.G. Holt, Pieter L.B. Bruijnzeel, Massimo Triggiani, Karen Britten, D.C. Reason, N. Sakaguchi, N.S. Sakaguchi, Ikuo Akutsu, G. Schultze-Werninghaus, R. Valenta, U. Blank, J.M. Vega, F. Leynadier, C. Ra, Bernhard Przybilla, K. Takatsu, Robin N. Poston, Larry D. Ward, P.K. Jeffery, Stephen R. Durham, J. Bujanowski-Weber, Nathalie Paul-Eugène, J. Dry, E.W. Rauterberg, B. Kunz, Christoph Walker, Richard J. Simpson, S. Wilson, V. Brinkmann, Ph. Lassalle, G. Burow, P.D. Pare, P. Oehme, Rafeul Alam, J. Knöller, R. Ciriilo, Conceição B. Santos, W. König, S. Bianchj, Allen C. Myers, K.R. Tainsh, Thomas Iff, E. Maggi, A. Miranda, T.D. Whalley, William Roche, Kimm J. Hamann, Lawrence M. Lichtenstein, Herbert G. Johnson, Kazuhiko Akiyoshi, Allen P. Kaplan, G. Delespesse, M.J. Carmona, H.Y.A. Lau, Kazuhiko Yamamoto, C. McMenamin, J. Wilson, Peter J. Barnes, Laura Palma-Carlos, A. Akasawa, G.M. Walsh, A. Capron, Toru Ando, W.R. Roche, Qiu Gang, Andrew F. Walls, Monique Capron, Sohei Makino, M. Lupini, Luanda Beck, J. Oliver, C. Baumgarten, L. Mugnai, C.J. Sanderson, Naohiro Watanabe, L. Lipponer, Alec H. Sehon, T. Furitsu, A. Ohgimi, Makoto Dohi, T. Brunnee, Elliott Homer, Diana J. Quint, A. Koffer, Friederike von zur Mühlen, R. Moqbel, Bradley J. Undem, Barbara K. Stout, Arnold S. Kirshenbaum, P.B. Boulos, Judah A. Denburg, M.-H. Jouvin, Werner J. Pichler, Shigeru Takafuji, M. Schon-Hegrad, Michael Breitenbach, G.M. Hänsch, Johannes Ring, J. Anrather, Robert L. Barker, Reinhold Penner, Otto Scheiner, L. Juhlin, Johann-Christian Virchow, Hirokazu Okudaira, E. Masini, S. Dunnette, Gerald J. Gleich, E. Gutierrez, Marshall Plaut, K. Nieber, F. Carswell, Piotr Kuna, R. Hilger, H. Küster, Clemens A. Dahinden, D. Macchia, W.L. Liu, M.P. Piccinni, Colin J. Sanderson, F. Gambassi, Jeffrey M. Drazen, Geoffrey A. Stewart, R. Wahl, G.J. Gleich, R. zur Strassen, R. Merget, M. Ricci, Menachem Rottem, John E. Salvaggio, Qutayba Hamid, Go Matsuzaki, Peter W. Heymann, Martin D. Chapman, P.E.R. Tatham, F. Chavarria, P. Wentz-Murtha, H. Wagner, S.J. Lane, Ph. Gosset, Akio Mori, K. Rother, Dietrich Kraft, Hans L. Spiegelberg, Kurt Blaser, A. Pistelli, Koki Takahashi, Kiyoshi Takatsu, D. Kraft, Martin E. Sanders, R. Suau, Stephen T. Holgate, T. Abe, Thomas Brunner, John Wilson, N. Hyslop, Alain L. de Weck, A. Hartnell, Corinne Petit-Frère, Zami Ben-Sasson, F. Bettens, Lore Koller, Yoji Iikura, U. Hauser, May Azzawi, Yutaka Morita, K. Ishida, M. G. Di Bello, Michael Duchêne, Koji Ito, Martin Krieger, D.R. Springall, Karin Pettenburger, J.M. Polak, Ahuva Nissim, Susanne Spitzauer, D. Befus, J.R. Wilkinson, Ch. Ebner, K.J. Turner, M. Bubak, F. Ledermann, Akira Ishii, Richard Sporik, M. Keating, A.B. Kay, Carvalho de Sousa, S.T. Holgate, B. Girn, S. Bent, Dieter Vieluf, Rihoux Jean-Pierre, W. Dorsch, Mitsuko Kondo, Claus Bachert, T.H. Lee, Suhad El-Lati, George W. Ward, E. Neher, R. Robert Schellenberg, Michiko Haida, Makoto Nogami, Brian M. Greenlee, Carl G. A. Persson, Anne Kagey-Sobotka, M. Pfenning, Dean D. Metcalfe, B.F. Weber, H. Rotermund, Shinji Motojima, J.W. Wilson, Tim R. Mosmann, Michael A. Lett-Brown, K. Kurihara, P.F. Mannaioni, Erika Jensen-Jarolim, Jack Gauldie, S. Raspanti, Andrew Grant, U. Ganzer, R. Fadel, R. Rathsack, Susan M. MacDonald, Toshifumi Yuuki, Sun Ying, B. Thomas, Rudolf Valenta, P. Parronchi, A. Ciccarelli, J.-P. Kinet, B.D. Gomperts, Takeo Juji, C. Brom, Hiroyuki Mochizuki, Gail M. McNutt, Alison M. Campbell, Takeshi Fukuda, K. Britten, Jordan N. Fink, J. Bews, Richard D. O’Connor, Stephan C. Bischoff, Miguel Blanca, P.H. Howarth, A.G. Morris, and A.G. Fernández

Subjects
Gerontology, media_common.quotation_subject, Immunology, Immunology and Allergy, Art history, General Medicine, Art, Biographical sketch, media_common
Published
1991
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11. Influence of Prostaglandin A1 on Renal Filtration, Hemodynamics and Excretion

Author

G. Schultze, Karl-Heinz Wagner, L. Schudrowitsch, Neumayer Hh, W. Ruf, G. Schwietzer, and M. Molzahn

Subjects
medicine.medical_specialty, business.industry, Extraction ratio, Prostaglandin, Renal function, Hemodynamics, General Medicine, Filtration fraction, Excretion, chemistry.chemical_compound, Endocrinology, chemistry, Nephrology, Renal blood flow, Internal medicine, Renal physiology, medicine, Cardiology and Cardiovascular Medicine, business
Abstract

The effect on renal function of a 210-min infusion of PGA1 into the aorta of 10 conscious beagle dogs has been investigated. In the sodium-replete group, PGA1 caused an increase in the glomerular filtration rate (GFR) (24%), renal blood flow (17%) and sodium excretion (20%). By contrast, in the sodium-depleted group, PGA1 caused a considerable reduction of GFR (25%) and sodium excretion (51%). In this group, baseline renal blood flow was lower, and there was no further reduction during PGA1 infusion. Fractional sodium excretion was unchanged in the sodium-replete dogs, but was reduced in the sodium-deplete state. Plasma renin activity was markedly elevated and further increased in the sodium-deplete group, but it was nearly unchanged in the sodium-replete group. This difference in renal response to exogenous PGA1 might be due to interaction with the renin-angiotensin system, which was markedly stimulated by sodium depletion and additionally by prostaglandin infusion.

Published
1983
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12. Contents, Vol. 41, 1981

Author

W. Nassari, Moigneteau C, A. Peters, J. Calamel, S. Bouzrina, Ordronneau J, G.E. Häfner, G. Schioppacassi, Munro Sherriff, G.R. Kennedy, Chailleux E, David A. Kaufmann, S. Arrenbrecht, J.D. Ginet, L. Gaucher, C.J.J. Westermann, S.S. Wagenaar, Edward W. Swenson, L. Curcio, P.J. Grob, G. Schultze-Werninghaus, G. Velluti, I. Zimmermann, W.T. Ulmer, M. Reinert, J. Oosting, M. Covi, and B. Wüthrich

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
1981
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13. Prostaglandin E2 Promotes Hypotension on Low-Sodium Hemodialysis

Author

Frieder Keller, Martin Molzahn, Santosh Nigam, Mahamane Maiga, H. H. Neumayer, G. Schultze, and Karl Wagner

Subjects
Mean arterial pressure, medicine.medical_specialty, business.industry, medicine.medical_treatment, Vasodilation, Plasma renin activity, Blood pressure, Endocrinology, Internal medicine, Anesthesia, Renin–angiotensin system, Medicine, Hemodialysis, Prostaglandin E2, business, Low sodium, medicine.drug
Abstract

The influence of low-sodium dialysate (126 mmol/l) on plasma levels of prostaglandin E2 (PGE2) and PGF2α, plasma renin activity (PRA) and arterial blood pressure was investigated in 16 patients on maintenance hemodialysis. PGE2 rose more than tenfold and there was a significant increase in PGF2α and PRA. Mean arterial pressure dropped by 30 mm Hg causing discomfort in several patients. By contrast, conventional hemodialysis against 140 mmol/l of sodium was followed by less pronounced changes in plasma prostaglandins, and reduction of blood pressure was moderate (13 mm Hg). It is suggested that vasodilating prostaglandins may contribute to dialysis hypotension. Their origin may not be confined to the kidneys but rather extend to the lungs and circulating blood cells. The in vitro generation of prostaglandins was demonstrated when donor blood was circulated in an extracorporeal dialysis system.

Published
1984
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14. Gastrointestinal Protein Loss in the Nephrotic Syndrome Studied with 51Cr-Albumin

Author

Ulrike Faber, Santosh Ahuja, Martin Molzahn, and G. Schultze

Subjects
medicine.medical_specialty, Fecal Excretion, business.industry, Feces analysis, Albumin, medicine.disease, Gastroenterology, Hypoproteinemia, Endocrinology, Internal medicine, Medicine, Digestive tract, Glomerular disease, business, Nephrotic syndrome
Abstract

Gastrointestinal protein loss was studied by intravenous application of 51Cr-albumin and the measurement of fecal excretion of 51Cr. As compared to controls, fecal excretion of 51Cr was largely increased in 28 patients with nephrotic syndrome due to glomerular disease and in 11 patients with hypoproteinemia in the course of different gastrointestinal disorders. It was not increased in nephrotic patients without primary glomerular disease and in renal insufficiency without nephrotic syndrome. Controversial data of the literature are discussed with regard to different methods and patient groups.

Published
1980
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15. Blood Pressure in Terminal Renal Failure

Author

G. Schultze, Sabine Piefke, and Martin Molzahn

Subjects
medicine.medical_specialty, Blood pressure, business.industry, medicine.medical_treatment, Internal medicine, Renin–angiotensin system, medicine, Cardiology, Renin-Substrate, business, Dialysis
Abstract

Most of the 52 patients on maintenance dialysis investigated in this study suffered from arterial hypertension in spite of efforts to reduce ‘dry weight’. In this situation we found that the majority

Published
1980
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16. Beneficial Effects of Long-Term Prostaglandin E2 Infusion on the Course of Postischemic Acute Renal Failure

Author

Neumayer Hh, L. Schudrowitsch, M. Molzahn, Karl-Heinz Wagner, J. Groll, and G. Schultze

Subjects
medicine.medical_specialty, business.industry, Extraction ratio, Urology, Renal function, General Medicine, Effective renal plasma flow, PAH clearance, Filtration fraction, Endocrinology, Nephrology, Renal blood flow, Internal medicine, Medicine, Prostaglandin E2, Cardiology and Cardiovascular Medicine, business, Beneficial effects, medicine.drug
Abstract

The effect of a continuous intra-aortal infusion of prostaglandin E2 (PGE2) (0.03 µg· min-1 • kg-1) on the course of postischemic renal failure (180 min cessation of blood flow by inflation of a pneumatic cuff) has been investigated in 11 conscious sodium-replete dogs. The glomerular filtration rate (51Cr-EDTA; endogenous creatinine clearance) was less decreased in the PGE2 group (group B, n = 6) than in the control group (group A, n = 5; 13 ml·min-1 vs. 22 ml min-1; p < 0.05). Renal blood flow (electromagnetic flow probe) was markedly lower in the control group (82 ml •min-1) than in the PGE2 group (130 ml • min-1; p < 0.05), even exceeding baseline levels in the latter group. Accordingly, the excessive rise in renal vascular resistance in the control group (+ 277%) was abolished in the PGE2 group (-20%) (ρ < 0.05). Nitrogen retention was also markedly improved. Plasma renin activity, which was markedly raised initially (25.8 ng angiotensin I·ml-1 h-1) was not significantly further increased during the subsequent 7 days. Urinary excretion of PGE2 was diminished in the control group and elevated following PGE2 infusion. It is suggested that the beneficial effects of PGE2 are mediated by preservation of renal perfusion. Additional effects of prostanoids on the ultrafiltration coefficient (KF) and cytoprotection by reduction of intracellular calcium accumulation must also be taken into consideration.

Published
1985
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17. Anticholinergic versus β2-Adrenergic Therapy in Allergic Airways Obstruction

Author

G. Schultze-Werninghaus

Subjects
Pulmonary and Respiratory Medicine, business.industry, medicine.drug_class, Adrenergic, Pharmacology, medicine.disease, respiratory tract diseases, Bronchodilator Effect, chemistry.chemical_compound, chemistry, Disodium cromoglycate, medicine, Anticholinergic, business, Oxitropium bromide, Fenoterol, medicine.drug, Asthma
Abstract

Two double-blind studies were performed in allergic subjects with bronchial asthma to evaluate the bronchodilator effect and antiallergic protection of oxitropium bromide (OTB), a new antiallergic dru

Published
1981
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19. Inhalt, Vol. 10, 1983

Author

K. Kühn, R. Lippoldt, E. Heinz, M. Török, S. Horsch, J. Hausdörfer, F. Yildiz, L. Heilmann, Müller Jm, P. Balcke, D. Feller, M. Molzahn, M. Butz, H. Stoeckel, W. Tschöpe, M. Schmitz, U. Brenner, U. Siekmann, P.H. Krause, H. Lobeck, D. Hausmann, R. Caspari, N. Merkle, W. Pommer, J.E. Schmitz, K.O. Mosebach, G. Offermann, A. Grünert, R. Dölp, A. Böhm, Hubert B. Keller, S. Berg, G. Schultze, and F.W. Ahnefeld

Subjects
Immunology and Allergy, Hematology
Published
1983
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20. Subject Index, Vol. 41, 1981

Author

S. Bouzrina, B. Wüthrich, M. Covi, J. Oosting, C.J.J. Westermann, David A. Kaufmann, Ordronneau J, G. Schioppacassi, G.R. Kennedy, Edward W. Swenson, G.E. Häfner, L. Curcio, J.D. Ginet, S.S. Wagenaar, G. Schultze-Werninghaus, A. Peters, W. Nassari, P.J. Grob, Chailleux E, Moigneteau C, S. Arrenbrecht, M. Reinert, W.T. Ulmer, Munro Sherriff, I. Zimmermann, J. Calamel, L. Gaucher, and G. Velluti

Subjects
Pulmonary and Respiratory Medicine, Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1981
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21. Subject Index, Vol. 37, 1984

Author

J.L. Anderton, Amin A. Nanji, Fumihiko Suehiro, Robert P. Waldman, C. Brigati, Takashi Kuwahara, K.H. Neumann, Kazuro Kanatsu, G. De Bartolo, Alan C. Bilsky, Shizuhiko Watanabe, Tadao Tamura, Koichi Matsumoto, Mary C. Stom, Yukio Ozawa, Martin Kay, C. Chizzolini, Renrick Benn, Robert G. Narins, Takao Saruta, Frieder Keller, Paul M. Rosman, Yasuhiro Amagasaki, Donald J. Campbell, G. Eckert, Michinobu Hatano, Mahamane Maiga, J. Schlarmann, Heinz Mrochen, L. Migone, Shigetoshi Senba, P. Dall’Aglio, Hisashi Katayama, Yoshihiro Hamashima, Kotaro Osakabe, Yukitoki Ikehara, P.L. Meroni, Kikuo Okano, Moritz Mebel, Eleanor Z. Wallace, G. Schultze, Hiroyuki Nagai, Hans-Hellmut Neumayer, Hiroshi Nakayashiki, H.J. Schurek, W. Barcellini, Konosuke Konishi, Santosh Nigam, Toshio Doi, Eiichi Kato, Martin Molzahn, Karin Müller, Takao Nagai, Wendy Adam, Petra Hoffmann, Isao Nakata, P.F. Williams, Chuichi Kawai, Klaus Thomsen, Groth J, Jürgen Kaden, Karl Wagner, D. Thomson, Marda Donner, and C. Zanussi

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1984
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22. The North of England Dermatological Society

Author

Franz Jahnel, Wilh Frohn, I.C. Neergaard, Berta Scharrer, C.W. Beijerinck, G. Schultze-Wolters, Albin Proppe, J.A. Folpmers, Harald Boas, M. Chruschtschow, Hans Thurn, and H. Hruszek

Subjects
medicine.medical_specialty, business.industry, Medicine, Dermatology, business
Published
1935
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23. Prof. Eugen Galewsky †

Author

J.A. Folpmers, C.W. Beijerinck, Berta Scharrer, Albin Proppe, Hans Thurn, H. Hruszek, M. Chruschtschow, G. Schultze-Wolters, Franz Jahnel, I.C. Neergaard, Harald Boas, and Wilh Frohn

Subjects
Dermatology
Published
1935
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