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Start Over Author "Ewa Kamińska" Publisher s. karger ag
4 results on '"Ewa Kamińska"'

1. Contents Vol. 94, 2014

Author

Ai Morioka, Irmgard Th. Lippe, Dongxue Hu, Xi-Long Zheng, Kazuhiro Nishiyama, Suyun Liu, Wenzhi Li, Da-Chun Chen, I. Okulicz-Kozaryn, Petra Luschnig, Matthias Hoch, Yong-Zhen Gong, Ying Zhang, Peter Valentin Tomazic, Li-Jun Cui, Xi Tan, Jacek Sapa, Ruining Zhang, Yasu-Taka Azuma, Wanchun Wang, Jing Liu, Ajnacska Rozsasi, Qing-Rong Tan, Le-Hua Li, Bingyan Guo, Duan-Fang Liao, Maria Gabriella Matera, Jasper Dingemanse, Cheng Chen, Shao-Wei Sun, Yi Cao, Anna M. Waszkielewicz, Maribel Reyes, Hong-Bo Zheng, Hidemitsu Nakajima, Szczepan Mogilski, Yuqing Li, Qin-Hui Tuo, Chi Ma, Yan Xiong, Hong-Geng Zhang, Philippe Girard, Henryk Marona, Przemysław Mikołajczak, Zao-Huo Cheng, Wojciech Leppert, Robert Frei, Ewa Kamińska, Monika Kubacka, Lin Zhang, Liang Chang, Tadayoshi Takeuchi, Girolamo Pelaia, Xue-Feng Yang, Marek Bednarski, Patrick Brossard, Xue-Jiao Xie, Takahiro Iwamoto, Xiu-Feng Xu, Eugenia Yiannakopoulou, Rosario Maselli, Yuelin Zeng, Katarzyna Raźny, Barbara Filipek, Yongjun Li, Yongdong Jiang, Jian-Guo Shi, Doris Lang-Loidolt, Satomi Kita, Jing-Ping Zhao, Michał Szulc, Hao-Yu Yuan, Gang Wang, Hongjie Xi, Yannick Pansart, Wei-Wei Xie, Marc Verleye, Rufina Schuligoi, Ke-Rang Zhang, Druckerei Stückle, and Akos Heinemann

Subjects
Pharmacology, General Medicine
Published
2014
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2. Analgesic Effects of Morphine in Combination with Adjuvant Drugs in Rats

Author

I. Okulicz-Kozaryn, Wojciech Leppert, Michał Szulc, Przemysław Mikołajczak, and Ewa Kamińska

Subjects
Male, Metoclopramide, Nausea, Midazolam, Analgesic, Pain, behavioral disciplines and activities, Pain ladder, Butylscopolammonium Bromide, mental disorders, Methotrimeprazine, medicine, Animals, Drug Interactions, Rats, Wistar, Adjuvants, Pharmaceutic, Pharmacology, Morphine, business.industry, Cancer, General Medicine, medicine.disease, respiratory tract diseases, nervous system diseases, Analgesics, Opioid, Anesthesia, Vomiting, Haloperidol, Delirium, Drug Therapy, Combination, medicine.symptom, Cancer pain, business, medicine.drug
Abstract

Background: Morphine is co-administered with adjuvant drugs to treat pain, nausea, vomiting, dyspnoea and delirium in cancer patients. Aim of the Study: To investigate analgesic effects of morphine when co-administered with adjuvant drugs. Material and Methods: Two-month-old male Wistar rats received single morphine doses alone (0.45 and 0.9 mg/kg) or with midazolam (0.3 mg/kg), haloperidol (0.15 and 0.45 mg/kg), levomepromazine (0.35 mg/kg), metoclopramide (1.0 mg/kg), and hyoscine butylbromide (1.7 mg/kg) as single subcutaneous injections. Analgesia was measured by the tail-flick test after 15, 30, 45, 60, and 90 min of drug administration. In the case of significant analgesia enhancement, analgesic and sedative effects were explored in 3-, 5-, 6-, 8-, and 11-month-old rats. Results: Significant morphine (0.9 mg/kg) analgesia enhancement was observed 60 min after haloperidol (0.15 and 0.45 mg/kg) and hyoscine butylbromide co-administration. The addition of haloperidol to morphine significantly increased analgesia in 6-, 8- and 11-month-old rats while in the case of hyoscine butylbromide co-administration this effect was observed only in 11-month-old rats. Conclusions: Haloperidol and hyoscine butylbromide enhanced morphine analgesia. Future studies may explore the repeated administration of these drug combinations in rats and humans. i 2014 S. Karger AG, Basel

Published
2014
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3. Analgesic Effects of Tramadol in Combination with Adjuvant Drugs: An Experimental Study in Rats

Author

Ewa Kamińska, I. Okulicz-Kozaryn, Przemysław Mikołajczak, and Wojciech Leppert

Subjects
Male, Metoclopramide, Midazolam, Analgesic, Pain, Pharmacology, Pain ladder, Levomepromazine, medicine, Haloperidol, Animals, Ketamine, Rats, Wistar, Tramadol, Adjuvants, Pharmaceutic, Analgesics, business.industry, General Medicine, Rats, Anti-Anxiety Agents, Anesthesia, Antiemetics, Drug Therapy, Combination, Analgesia, business, Antipsychotic Agents, medicine.drug
Abstract

Background: Tramadol is often coadministered subcutaneously with adjuvants to treat pain, nausea/vomiting, dyspnea and delirium in cancer patients. The aim of the study was to investigate analgesia of tramadol coadministered with adjuvants in rats. Materials and Methods: Male rats (Wistar race) received a single tramadol dose separately (0.45 mg/kg) or tramadol with haloperidol (0.45 mg/kg), midazolam (0.3 mg/kg), levomepromazine (0.35 mg/kg), metoclopramide (1.0 mg/kg), hyoscine butylbromide (1.7 mg/kg) or ketamine (0.3 mg/kg) as a single subcutaneous injection. Analgesia was measured by a tail flick test after 15, 30, 60 and 90 min of drug administration. Results: Tramadol analgesia was enhanced with haloperidol (30, 60 and 90 min) and with midazolam (60 and 90 min). Tramadol with levomepromazine (30, 60 and 90 min) and tramadol with metoclopramide (30 and 90 min) attenuated tramadol analgesia. Tramadol with hyoscine butylbromide and tramadol with ketamine did not change tramadol analgesia. Conclusions: Significant changes in tramadol analgesia after the administration of different adjuvants could be demonstrated in this experimental single-dose study. Future clinical trials have to further explore the benefits of these drug combinations.

Published
2013
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4. Acknowledgement to Referees for Pharmacology 2014

Author

Suyun Liu, Ajnacska Rozsasi, Lin Zhang, Yongjun Li, Yasu-Taka Azuma, Doris Lang-Loidolt, Liang Chang, Xue-Feng Yang, Jing-Ping Zhao, Ruining Zhang, Li-Jun Cui, Xi Tan, I. Okulicz-Kozaryn, Xi-Long Zheng, Patrick Brossard, Rosario Maselli, Hong-Bo Zheng, Kazuhiro Nishiyama, Satomi Kita, Yi Cao, Le-Hua Li, Philippe Girard, Wojciech Leppert, Anna M. Waszkielewicz, Yan Xiong, Szczepan Mogilski, Ai Morioka, Marek Bednarski, Barbara Filipek, Ewa Kamińska, Wenzhi Li, Monika Kubacka, Matthias Hoch, Przemysław Mikołajczak, Jacek Sapa, Ying Zhang, Wanchun Wang, Yuelin Zeng, Girolamo Pelaia, Qing-Rong Tan, Peter Valentin Tomazic, Duan-Fang Liao, Jasper Dingemanse, Hidemitsu Nakajima, Yuqing Li, Hongjie Xi, Henryk Marona, Yannick Pansart, Wei-Wei Xie, Takahiro Iwamoto, Robert Frei, Yong-Zhen Gong, Maribel Reyes, Qin-Hui Tuo, Petra Luschnig, Bingyan Guo, Marc Verleye, Rufina Schuligoi, Shao-Wei Sun, Michał Szulc, Tadayoshi Takeuchi, Chi Ma, Hao-Yu Yuan, Gang Wang, Dongxue Hu, Ke-Rang Zhang, Da-Chun Chen, Katarzyna Raźny, Jing Liu, Maria Gabriella Matera, Yongdong Jiang, Xiu-Feng Xu, Jian-Guo Shi, Hong-Geng Zhang, Druckerei Stückle, Akos Heinemann, Irmgard Th. Lippe, Zao-Huo Cheng, Xue-Jiao Xie, Eugenia Yiannakopoulou, and Cheng Chen

Subjects
Pharmacology, Medical education, Acknowledgement, General Medicine, Psychology
Published
2014
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