1. High Prevalence of Polycystic Ovary Syndrome in Type 1 Diabetes Mellitus Adolescents: Is There a Difference Depending on the NIH and Rotterdam Criteria?
- Author
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Evelyne Jacqz-Aigrain, Christine Delcroix, D. Martin, Maud Bidet, Nadia Tubiana-Rufi, K. Laborde, Ana Colmenares, Dinane Samara-Boustani, Jean-Jacques Robert, Claire Levy-Marchal, L. Benadjaoud, Kanetee Busiah, Paul Jacquin, and Michel Polak
- Subjects
medicine.medical_specialty ,Adolescent ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Diabetes Complications ,Adult women ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Prevalence ,Humans ,Medicine ,Child ,Gynecology ,Type 1 diabetes ,030219 obstetrics & reproductive medicine ,High prevalence ,business.industry ,Puberty ,Hyperandrogenism ,nutritional and metabolic diseases ,medicine.disease ,Polycystic ovary ,Oligomenorrhea ,Diabetes Mellitus, Type 1 ,Diabetes Mellitus, Type 2 ,Pediatrics, Perinatology and Child Health ,Female ,business ,Polycystic Ovary Syndrome - Abstract
Background: Polycystic ovary syndrome (PCOS) is more frequently observed in type 1 diabetes mellitus (T1DM) adult women than in nondiabetic women. No such prevalence has yet been studied in adolescent girls with T1DM. Aim: The aim of this study was to evaluate the prevalence of PCOS in adolescent girls with T1DM and to determine the clinical and hormonal features associated with the disorder. Methods: A cross-sectional study of 53 adolescent girls (gynecological age >2 years) referred for routine evaluation for T1DM was conducted. We diagnosed PCOS using the National Institutes of Health (NIH) and Rotterdam criteria. Results: 26.4 and 47.9% of adolescents had PCOS according to NIH (NIH-PCOS) and Rotterdam (Rotterdam-PCOS) criteria. 66.7% of NIH-PCOS adolescents had a complete phenotype associated with hyperandrogenism, oligomenorrhea, and polycystic ovarian morphology, unlike only 33.3% of the Rotterdam-PCOS adolescents. A family history of type 2 diabetes mellitus (T2DM) was more frequent in PCOS than in non-PCOS girls, whichever criteria were used. Late pubertal development and a T1DM diagnosis close to puberty were factors associated with NIH-PCOS. Conclusion: Adolescents with T1DM had a high prevalence of PCOS. More differences between PCOS and non-PCOS patients were found using the NIH criteria, suggesting that clinical characteristics might be more accurate for diagnosing PCOS in girls with T1DM. A family history of T2DM is associated with a high risk of PCOS.
- Published
- 2017
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