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1. Migraine and Risk of Dementia: A Nationwide Retrospective Cohort Study

Author

Chieh-Sen Chuang, Fung-Chang Sung, Ming-Chia Lin, Cheng-Li Lin, and Chia-Hung Kao

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Epidemiology, Migraine Disorders, Taiwan, MEDLINE, Comorbidity, Disease, Cohort Studies, Risk Factors, mental disorders, Humans, Medicine, Dementia, Psychiatry, Aged, Retrospective Studies, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Migraine, Female, Neurology (clinical), business, Cohort study
Abstract

Objective: Migraines are one of the most common neurological disorders. Dementia is a neurodegenerative disease characterized by slow progressive memory loss and cognitive dysfunction. This retrospective cohort study investigates the association between migraines and dementia using a nationwide population-based database in Taiwan. Methods: We retrieved the data analyzed in this study from the National Health Insurance Research database (NHIRD) in Taiwan. We used multivariate Cox proportion-hazards regression models to assess the effects of migraines on the risk of dementia after adjusting for sociodemographic characteristics and comorbidities. Results: The migraine cohort had a higher prevalence of diabetes, hypertension, coronary artery disease, head injury and depression at baseline (p < 0.0001). After adjusting the covariates, migraine patients had a 1.33-fold higher risk of developing dementia [hazard ratio (HR) 1.33, 95% confidence interval (CI) 1.22-1.46]. The sex-specific incidence rate of dementia was higher in men than in women in both cohorts, with an HR of 1.09 (95% CI 1.00-1.18) for men compared to women. Kaplan-Meier analysis shows that the cumulative incidence of dementia was 1.48% greater in the migraine cohort than in the nonmigraine cohort (log-rank test, p < 0.0001). Conclusions: This study shows that migraines are associated with a future higher risk of dementia after adjusting for comorbidities. Specifically, the association between migraine and dementia is greater in young adults than in older adults.

Published
2013
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2. Contents Vol. 41, 2013

Author

S. Neumaier, Kristine Hoffmann, Joseph C. Chang, Benoit Daubail, C. Diehm, Elena Ruiz, Richard W. Price, Shanthi Ameratunga, B. Reuter, James T. Becker, W. Hacke, Ahunna Onyenwenyi, Satz Mengensatzproduktion, Haruo Kanno, Inga Liepelt-Scarfone, Asmus Vogel, P Johannsen, S. Rode, Yannick Béjot, Monika Fruhmann Berger, M. Daffertshofer, M.G. Hennerici, Chia-Hung Kao, Druckerei Stückle, Katharina Gauss, Enrique Ramalle-Gomara, Johannes Streffer, Gunhild Waldemar, Hetal Patel, Daniela Berg, Carol Chelimo, Maria-Angeles Gonzalez, Maurice Giroud, Cheng-Li Lin, Belinda Matute, Nanna Aue Sobol, P.A. Ringleb, Carl W. Cotman, Meredith Edwards, E. Drewitz, W. John Boscardin, W. Habscheid, Kristian Steen Frederiksen, Ana-Claire Meyer, Christian Bormann, Marta Serrano, Monica Bartulos, Agnès Jacquin, Beth E. Snitz, Mamuka Teneishvili, Alain Ruffion, Toshimi Aizawa, Bridget Kool, Jérôme Durier, Ming-Chia Lin, Fung-Chang Sung, Ole Terkelsen, Corinne LeReun, Annette Lolk, Chieh-Sen Chuang, Steen G. Hasselbalch, Eiji Itoi, David Castro-Diaz, Nina Beyer, Judith K. Kwasa, Katharina Müller, H. Wiethölter, Maarten Timmers, I. Bruder, C. Gumbinger, Anja Hviid Simonsen, Kristin Khalaf, Hirotaka Sano, Gustavo Saposnik, R. Kern, Walter Maetzler, and Hiroshi Ozawa

Subjects
Traditional medicine, Epidemiology, business.industry, Medicine, Neurology (clinical), business
Published
2013
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3. 3rd International Congress on Neurology and Epidemiology. Abu Dhabi, UAE, November 21–23, 2013: Abstracts

Author

W. Habscheid, Marta Serrano, Satz Mengensatzproduktion, Yannick Béjot, Haruo Kanno, W. John Boscardin, Johannes Streffer, Steen G. Hasselbalch, Elena Ruiz, M.G. Hennerici, Chia-Hung Kao, Asmus Vogel, Joseph C. Chang, Judith K. Kwasa, I. Bruder, Monika Fruhmann Berger, Cheng-Li Lin, Maurice Giroud, R. Kern, P Johannsen, Katharina Müller, Anja Hviid Simonsen, Carl W. Cotman, Katharina Gauss, Druckerei Stückle, Kristian Steen Frederiksen, H. Wiethölter, Shanthi Ameratunga, B. Reuter, Hetal Patel, Richard W. Price, Enrique Ramalle-Gomara, Ana-Claire Meyer, Jérôme Durier, Benoit Daubail, Daniela Berg, Chieh-Sen Chuang, Kristine Hoffmann, Toshimi Aizawa, Eiji Itoi, Gustavo Saposnik, Fung-Chang Sung, Gunhild Waldemar, S. Rode, Hirotaka Sano, Ole Terkelsen, P.A. Ringleb, S. Neumaier, W. Hacke, Nanna Aue Sobol, Monica Bartulos, David Castro-Diaz, Inga Liepelt-Scarfone, C. Diehm, James T. Becker, Agnès Jacquin, Nina Beyer, Alain Ruffion, M. Daffertshofer, Mamuka Teneishvili, Maarten Timmers, Christian Bormann, Maria-Angeles Gonzalez, Bridget Kool, C. Gumbinger, Meredith Edwards, Beth E. Snitz, Kristin Khalaf, Belinda Matute, E. Drewitz, Annette Lolk, Ming-Chia Lin, Corinne LeReun, Ahunna Onyenwenyi, Hiroshi Ozawa, Walter Maetzler, and Carol Chelimo

Subjects
medicine.medical_specialty, Abu dhabi, Epidemiology, business.industry, International congress, Library science, Medicine, Optometry, Neurology (clinical), business
Published
2013
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4. Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery

Author

Shou-Jen Kou, Yu-Chi Li, Yau-Huei Wei, Ko-Hung Liu, Chin-San Liu, Jui-Chih Chang, Chieh-Sen Chuang, and Mingli Hsieh

Subjects
Mitochondrial DNA, Mitochondrial disease, MFN2, Mitochondrion, Biology, medicine.disease, Molecular biology, Human mitochondrial genetics, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology, Mitochondrial biogenesis, medicine, Optic Atrophy 1, ATP–ADP translocase
Abstract

We explored the feasibility of mitochondrial therapy using the cell-penetrating peptide Pep-1 to transfer mitochondrial DNA (mtDNA) between cells and rescue a cybrid cell model of the mitochondrial disease myoclonic epilepsy with ragged-red fibres (MERRF) syndrome. Pep-1-conjugated wild-type mitochondria isolated from parent cybrid cells incorporating a mitochondria-specific tag were used as donors for mitochondrial delivery into MERRF cybrid cells (MitoB2) and mtDNA-depleted Rho-zero cells (Mitoρ°). Forty-eight hours later, translocation of Pep-1-labelled mitochondria into the mitochondrial regions of MitoB2 and Mitoρ° host cells was observed (delivery efficiencies of 77.48 and 82.96%, respectively). These internalized mitochondria were maintained for at least 15 days in both cell types and were accompanied by mitochondrial function recovery and cell survival by preventing mitochondria-dependent cell death. Mitochondrial homeostasis analyses showed that peptide-mediated mitochondrial delivery (PMD) also increased mitochondrial biogenesis in both cell types, but through distinct regulatory pathways involving mitochondrial dynamics. Dramatic decreases in mitofusin-2 (MFN2) and dynamin-related protein 1/fission 1 were observed in MitoB2 cells, while Mitoρ° cells showed a significant increase in optic atrophy 1 and MFN2. These findings suggest that PMD can be used as a potential therapeutic intervention for mitochondrial disorders.

Published
2012
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5. Acknowledgements to Referees

Author

Richard W. Price, Hetal Patel, Shanthi Ameratunga, C. Diehm, Elena Ruiz, James T. Becker, B. Reuter, S. Neumaier, P Johannsen, Monika Fruhmann Berger, Daniela Berg, Ahunna Onyenwenyi, Nanna Aue Sobol, W. Hacke, Hirotaka Sano, Yannick Béjot, Benoit Daubail, Steen G. Hasselbalch, Monica Bartulos, Agnès Jacquin, Cheng-Li Lin, Alain Ruffion, Maarten Timmers, Carol Chelimo, Joseph C. Chang, Eiji Itoi, Ming-Chia Lin, Haruo Kanno, I. Bruder, S. Rode, Annette Lolk, C. Gumbinger, W. John Boscardin, P.A. Ringleb, Mamuka Teneishvili, W. Habscheid, Anja Hviid Simonsen, M. Daffertshofer, R. Kern, Kristin Khalaf, Katharina Gauss, Corinne LeReun, Ana-Claire Meyer, Bridget Kool, Jérôme Durier, Kristine Hoffmann, H. Wiethölter, Toshimi Aizawa, Belinda Matute, Chieh-Sen Chuang, Gunhild Waldemar, Fung-Chang Sung, Judith K. Kwasa, Ole Terkelsen, M.G. Hennerici, Chia-Hung Kao, Enrique Ramalle-Gomara, Marta Serrano, Katharina Müller, Kristian Steen Frederiksen, Druckerei Stückle, Christian Bormann, Beth E. Snitz, E. Drewitz, Gustavo Saposnik, Maurice Giroud, Carl W. Cotman, David Castro-Diaz, Walter Maetzler, Nina Beyer, Hiroshi Ozawa, Asmus Vogel, Johannes Streffer, Inga Liepelt-Scarfone, Maria-Angeles Gonzalez, Meredith Edwards, and Satz Mengensatzproduktion

Subjects
Medical education, Epidemiology, business.industry, Medicine, Neurology (clinical), business
Published
2010
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