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Your search keyword '"Antinematodal agent"' showing total 2 results
Start Over Descriptor "Antinematodal agent" Publisher s. karger ag
2 results on '"Antinematodal agent"'

1. Intestinal Parasitic Infections

Author

David Botero

Subjects
Antinematodal agent, Protozoan infection, medicine, Biology, Cestode infections, medicine.disease, Anticestodal Agents, Microbiology
Published
2015
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2. Experimental Chemotherapy and Toxicity in Mice of Three Mebendazole Polymorphic Forms

Author

A. Criado-Fornelio, L. Guzman, A. Igual, A. Jimenez-Gonzalez, A. Perez, F. Rodriguez-Caabeiro, and M. Pujol

Subjects
Male, Antinematodal agent, Pyridines, Trichinella spiralis, Mebendazole, Administration, Oral, Pharmacology, Enteral administration, Median lethal dose, Lethal Dose 50, Mice, Oral administration, Drug Discovery, medicine, Animals, Pharmacology (medical), Anthelmintic, biology, Antinematodal Agents, Trichinellosis, General Medicine, biology.organism_classification, Infectious Diseases, Oncology, Larva, Toxicity, Female, Injections, Intraperitoneal, medicine.drug
Abstract

In an attempt to test the biological activity of three polymorphic forms of mebendazole (MBZ), called A, B and C, both the LD50 in mice after oral (p.o.) and intraperitoneal (i.p.) administration and the anthelmintic effect of these forms on the enteral and parenteral phases of the nematode Trichinella spiralis were studied. We observed that the polymorphic form A was the least toxic and effective against T. spiralis. The use of the polymorph C is advisable for oral treatment with MBZ in mice, having in mind its lower toxicity with regard to the polymorphic form B and its similar anthelmintic effects.

Published
1987
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