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Your search keyword '"Akihiro Munakata"' showing total 3 results
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3 results on '"Akihiro Munakata"'

1. Title Page / Contents / Members of the Symposium / Preface / Introductory Remarks

Author

Masataka Kojima, Masanori Okui, Hiroshi Kiyono, Hironobu Sasano, Kazunori Tashiro, Hitoshi Asakura, Keiichi Mitsuyama, Toshiro Sato, Haruo Otani, Zhang-xu Liu, Kisei Ishizuka, Toshifumi Hibi, Mitsunori Noguchi, Hiroshi Serizawa, Osamu Kanauchi, Ken Toshina, Atsushi Toyonaga, Takayoshi Toyota, Yuji Naito, Hiroshi Nagura, Nobuo Okabe, Ryota Hokari, Hidekazu Suzuki, Michio Sata, Asuka Suzuki, Kazuhito Sugimura, Masaaki Adachi, Yuji Hinoda, Tomoyuki Tsujikawa, Nobuhide Oshitani, Hiroko Bamba, Taiji Yamaguchi, Soichiro Miura, Shiro Nakamura, Ken-ichi Katsu, Yoshihiro Fukuda, Yoh Ishiguro, Yoshihide Fujiyama, Tsutomu Mochizuki, Masatoshi Nitta, Toshio Kimura, Yoshikazu Tsuzuki, Jun-ichi Hara, Akira Andoh, Terasu Homma, Kouji Suzuki, Yuriko Hara, Mi-Na Kweon, Hiroyoshi Utsumi, Tetsuo Arakawa, Tohru Takahashi, Takanori Kanai, Akihiro Munakata, Nobuo Tomiyasu, Hiroyuki Sakata, Haruo Ohtani, Yoshinori Sawa, Toshihiko Iwanaga, Masamichi Satomi, Yoshio Araki, Tadao Bamba, Fumio Itoh, Satoshi Motoya, Kosuke Takaki, Kazufumi Yamagata, Mitsuyuki Murano, Ichiro Takahashi, Bin Wu, Kohzoh Imai, Ichiro Hirata, Kazuaki Otsuka, Kazuma Fujimoto, Hirotake Sakuraba, Kentaro Maemura, Noritoshi Tanida, Hiromasa Ishii, Akira Okazawa, Takayuki Matsumoto, Osamu Yamaguchi, Toshikazu Yoshikawa, Shin-ichi Sasaki, Takashi Nishigami, Hiroshi Kanazawa, Yasunari Nakamura, Jun Matsuzawa, Takahiro Noda, Mamoru Watanabe, Norimasa Yoshida, Yoshio Jinno, Toshiaki Hayashi, Shunsuke Komoto, Shuji Nakagawa, Takashi Shimoyama, Masaaki Kobayashi, Ryuichi Iwakiri, Seiichiro Koseki, Tadao Ishida, Kazutami Tamura, Hitoshi Fujimori, Sadatoshi Ishibashi, and Nobuo Hiwatashi

Subjects
media_common.quotation_subject, Gastroenterology, Art, Title page, Classics, media_common
Published
2001
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2. Existence of Variant γδT Cells in Crohn’s Disease

Author

Hiroshi Kanazawa, Hirotake Sakuraba, Akihiro Munakata, Kazufumi Yamagata, and Yoh Ishiguro

Subjects
Pathogenesis, Crohn's disease, Crohn disease, Immunology, Gastroenterology, medicine, Biology, medicine.disease, Phenotype, γδt cells
Abstract

Background and Objectives: γδT cell populations are well-known for their unique distribution (e.g. intra-epithelial lymphocytes). Though their ligands play a major role in the immune response they have remained largely obscure. To shed light on this issue, we have analyzed in this study the complementarity determining region (CDR) 3 of the T cell receptor (TCR) Vδ2 chains. This provides an insight into the antigenic immune response in the intestinal mucosa in sickness and health. Methodology: Total RNA was extracted from surgically resected intestinal mucosa of patients with Crohn’s disease (CD) and controls. TCR Vδ2 cDNA was PCR-amplified using Vδ2 sense primer and Cδ antisense primer. The PCR products were then subcloned in pUC18 plasmid. From each sample, 20 subclones were randomly selected and subjected to nucleotide sequence analysis. Results: Sequence analysis revealed that the CDR3 sequences of the TCR Vδ2 chains were unique to each individual. The evidence also showed a significant restriction of the junctional diversity of the TCR Vδ2 chains while no such restriction was found for CD. Conclusions: The marked complexity of the TCR Vδ2 junctional sequences and the oligoclonality of the TCR Vδ2 genes in the control subjects are indicative of a positive selection and expansion of specific T cells in the normal, healthy condition. In CD patients, however, the expression of distinct, non-overlapping TCR Vδ2 clonotypes can be found, suggesting polyclonal activation of γδT cells in the diseased colon of CD patients. These findings have led us to conclude that accumulation of multiple γδT cell clonotypes may be involved in the pathogenesis of CD.

Published
2001
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3. Author and Subject Index

Author

Kisei Ishizuka, Mi-Na Kweon, Masaaki Adachi, Akihiro Munakata, Ryota Hokari, Terasu Homma, Yoshio Jinno, Zhang-xu Liu, Masamichi Satomi, Akira Andoh, Kosuke Takaki, Nobuo Hiwatashi, Haruo Otani, Masataka Kojima, Hiroyuki Sakata, Tetsuo Arakawa, Satoshi Motoya, Atsushi Toyonaga, Kazufumi Yamagata, Nobuo Tomiyasu, Toshiaki Hayashi, Ichiro Takahashi, Yoshinori Sawa, Kazuaki Otsuka, Osamu Kanauchi, Ken Toshina, Takayuki Matsumoto, Nobuhide Oshitani, Noritoshi Tanida, Shunsuke Komoto, Michio Sata, Asuka Suzuki, Toshikazu Yoshikawa, Mitsuyuki Murano, Hiroshi Kiyono, Takashi Shimoyama, Hiroko Bamba, Mamoru Watanabe, Yoshihiro Fukuda, Toshio Kimura, Yoshihide Fujiyama, Yoshikazu Tsuzuki, Hirotake Sakuraba, Tadao Bamba, Toshifumi Hibi, Kentaro Maemura, Shuji Nakagawa, Hitoshi Asakura, Soichiro Miura, Shiro Nakamura, Yoh Ishiguro, Sadatoshi Ishibashi, Ryuichi Iwakiri, Yasunari Nakamura, Taiji Yamaguchi, Tsutomu Mochizuki, Keiichi Mitsuyama, Haruo Ohtani, Mitsunori Noguchi, Kouji Suzuki, Toshiro Sato, Takanori Kanai, Kazuma Fujimoto, Kazuhito Sugimura, Hidekazu Suzuki, Seiichiro Koseki, Masatoshi Nitta, Kohzoh Imai, Tadao Ishida, Kazutami Tamura, Yoshio Araki, Hiromasa Ishii, Hitoshi Fujimori, Jun-ichi Hara, Toshihiko Iwanaga, Tohru Takahashi, Akira Okazawa, Hironobu Sasano, Yuriko Hara, Takayoshi Toyota, Fumio Itoh, Hiroyoshi Utsumi, Norimasa Yoshida, Bin Wu, Masaaki Kobayashi, Hiroshi Serizawa, Shin-ichi Sasaki, Tomoyuki Tsujikawa, Hiroshi Kanazawa, Masanori Okui, Nobuo Okabe, Osamu Yamaguchi, Jun Matsuzawa, Takahiro Noda, Yuji Hinoda, Kazunori Tashiro, Ichiro Hirata, Yuji Naito, Hiroshi Nagura, Ken-ichi Katsu, and Takashi Nishigami

Subjects
medicine.medical_specialty, Index (economics), business.industry, Gastroenterology, Medicine, Subject (documents), Medical physics, business, Surgery
Published
2001
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