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Start Over Author "Yogesh A. Sabnis" Publisher royal society of chemistry (rsc)
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1. Investigation of the effect of molecular properties on the binding kinetics of a ligand to its biological target

Author

Paul Driscoll, Miller Duncan Charles, Nichola L. Davies, Peter Jones, Graham Lunn, and Yogesh A. Sabnis

Subjects
Pharmacology, Stereochemistry, Chemistry, Biological target, Ligand, Computational chemistry, Drug Discovery, Organic Chemistry, Pharmaceutical Science, Molecular Medicine, Dissociation kinetics, Biochemistry, Receptor–ligand kinetics
Abstract

A database of binding kinetic data across multiple targets has been created. Analysis of this database provides insights into trends for the effects of physicochemical properties (molecular weight, clogP, rotatable bond count) on the dissociation kinetics of ligands from their biological targets.

Published
2012
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