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The backbone linker for two ortho-bis-(9-borafluorene)s influences the LUMO at the boron centers and the reactivity of the respective compounds.

A 9-carboranyl-substituted 9-borafluorene is reported, which is capable of undergoing efficient ring expansion to 6,7-dihydroborepins by a previously unknown alkene insertion.

cerebral malaria (CM) is an important complication of malaria with a high mortality rate. Artesunate is recommended as the first-line artemisinin compound treatment for severe malaria. Due to the difficulty of obtaining brain tissue samples clinically, the use of animals to research host responses to CM parasite infections is necessary. Rodent malaria models allow for detailed time series studies of host responses in multiple organs. To date, studies on the transcriptome of severe malaria are only limited to the parasites in the peripheral blood of patients, and there is little data on the transcriptional changes in brain tissue in mice with CM treated with artesunate.in this study, fresh tissue samples (three biological replicates per mouse) from the same area of the brain in each animal were collected from the uninfected,the mechanism of improving the prognosis of cerebral malaria by artesunate may not only involve the killing of plasmodium but also the inhibition of a cytokine storm in the host. This study provides new insights into the molecular mechanism by which artesunate improves the prognosis of cerebral malaria.

A di(o-tolyl)borylgold complex was synthesized via the metathesis reaction of a gold alkoxide with tetra(o-tolyl)diborane(4). The resulting diarylborylgold complex exhibited a Lewis acidic boron center and a characteristic visible absorption that arises from its HOMO–LUMO excitation, which is narrower than that of a previously reported dioxyborylgold complex. The diarylborylgold complex reacted with isocyanide in a stepwise fashion to afford single- and double-insertion products and a C–C coupled product. Reactions of this diarylborylgold complex with C Created by potrace 1.16, written by Peter Selinger 2001-2019 O/N double bond species furnished addition products under concomitant formation of Au–C and B–O/N bonds, which suggests nucleophilic reactivity of the gold metal center. DFT calculations provided details of the underlying reaction mechanism, which involves an initial coordination of the CO/N bond to the boron vacant p-orbital of the diarylboryl ligand followed by a migration of the gold atom from the tetracoordinate sp3-hybridized boron center, which is analogous to the reactivity of the conventional sp3-hybridized borate species. The DFT calculations also suggested a stepwise mechanism for the reaction of this diarylborylgold complex with isocyanide, which afforded three different reaction products depending on the applied reaction conditions., A di(o-tolyl)borylgold complex added to CO/N double bond to form Au–C and B–O/N bonds. DFT calculations revealed a two-step mechanism consisting of the coordination of O/N atom to B atom followed by nucleophilic migration of Au atom.

DFT calculations have been performed to study the relative preference of different unsaturated organic molecules (CO2, PhCHO and styrene) for insertion into different Cu–X (X = B, C, O) bonds, which are competing processes in copper-catalyzed three-component boracarboxylation reactions involving CO2 and B2pin2. In this work, the variations in the insertion barriers and in the relative stability of the insertion products have been systematically analyzed and discussed in-depth. Our DFT calculations also allow us to make a prediction that when both aldehyde and styrene are present with CO2 and B2pin2, styrene will undergo the three-component boracarboxylation reaction rather than the aldehyde.

The 4-coordinated RuII chalcogenolate complexes [Ru(STipp)2(PPh3)2] (Tipp = 2,4,6-triisopropylphenyl, 1) and [Ru(SeMes)2(PPh3)2] (Mes = 2,4,6-trimethylphenyl, 2) have been synthesized, and their reactions with PhICl2 and organic azides have been studied. Complex 2 synthesized from [RuII(PPh3)3Cl2] and NaSeMes displays a seesaw structure with P–Ru–P and Se–Ru–Se bond angles of 103.43(13) and 145.26(6)°, respectively. Natural bond order analyses revealed that in each of 1 and 2, there are two n → σ* (donor–acceptor) π interactions between the chalcogen lone pairs and the Ru–P antibonding molecular orbitals. The calculated second-order perturbation interaction energies of the two interactions for 1 (20.5 and 18.3 kcal mol−1) are stronger than those of 2 (13.6 and 11.0 kcal mol−1), suggesting the thiolate ligand (TippS−) is a stronger π-donor than the selenolate ligand (MesSe−) with respect to RuII. Chlorination of 1 with PhICl2 afforded the dichloride complex [Ru(STipp)2Cl2(PPh3)] (3), which was hydrolyzed to the hydroxo complex [Ru(STipp)2(OH)Cl(PPh3)] (4) after column chromatography on silica in air. Treatment of 4 with HCl and methyl triflate gave 3 and [Ru(STipp)2(OH)(OTf)(PPh3)] (OTf = triflate, 5), respectively. Reactions of 1 and 2 with p-tolyl azide (p-tolN3) afforded the tetrazene complexes [Ru{N4(p-tol)2}(ER)2(PPh3)] (ER = STipp (6), SeMes (7)), whereas that with tosyl azide (TsN3) gave the imido complexes [Ru(κ2-NTs)(STipp)2(PPh3)] (ER = STipp (8), SeMes (10)). The short Ru–Nimido distances in 8 [1.883(3) A] and 10 [1.892(2) A] are indicative of multiple bond character. Treatment of 8 with TsN3 afforded the tetrazene complex [Ru(N4Ts2)(STipp)2(PPh3)] (9), but no cycloaddition was found between 10 and TsN3. Nucleophilic attack of the imido ligand in 10 with methyl triflate yielded the amido complex [Ru(κ2-NMeTs)(SeMes)2(PPh3)](OTf) (11). The crystal structures of 2, 4, 6, and 8–11 have been determined.

Novel CoMoO4 and Ni1/3Co2/3MoO4 nanosheets were synthesized by a time-saving solvothermal method with medium conditions, and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and high-resolution TEM (HRTEM). Enhanced specific capacitance (1032.39 F g−1 at 4 A g−1) and good cycle stability (remaining 85.18% at after 1000 cycles) are observed in aqueous KOH electrolytes of Ni1/3Co2/3MoO4 nanosheets, which could be ascribed to the high charge accommodation, small ion-transport resistance, and good electrical conductivity of the ultrathin nanosheet structure. In addition, the as-prepared CoMoO4 nanosheets exhibited good electrocatalytic activity toward the oxidation of glucose.