1. New insights into the metal-induced oxidative degradation pathways of transthyretin
- Author
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Jacob W. McCabe, David H. Russell, Zahra Moghadamchargari, Arthur Laganowsky, Mehdi Shirzadeh, and Michael L. Poltash
- Subjects
biology ,Oxidative degradation ,010405 organic chemistry ,Chemistry ,Disease progression ,Metals and Alloys ,nutritional and metabolic diseases ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Oligomer ,Article ,Catalysis ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Metal ,Transthyretin ,chemistry.chemical_compound ,visual_art ,Materials Chemistry ,Ceramics and Composites ,biology.protein ,visual_art.visual_art_medium ,Biophysics - Abstract
The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leading to N-terminal backbone fragmentation and oligomer formation; previously hidden details were revealed only by FT-IM-Orbitrap MS and surface-induced dissociation.
- Published
- 2019
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