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The first photo-induced nickel-mediated regioselective radical–radical cross-electrophile coupling process with alkyl NHP esters and EDA complexes for alkylated allenes is described.

An environmentally benign electrochemical decyanative C(sp3)–H oxygenation of N-cyanomethylamines for the synthesis of structurally diverse formamides is described.

This review covers the recent progress in electrochemically enabled radical-mediated aryl/alkenyl C(sp2)–C(sp3) cross-coupling reactions, including synthetic strategies, plausible mechanisms and further research outlook.

Glycals are highly versatile and useful building blocks in the chemistry of carbohydrate and natural products. However, the practical synthesis of glycals remains a long-standing and mostly unsolved problem in synthetic chemistry. Herein, we present an unprecedented approach to make a variety of glycals using phosphonium hydrolysis-induced, P(v) intermediate-mediated E1cB elimination. The method provides a highly efficient, practical and scalable strategy for the synthesis of glycals with good generality and excellent yields. Furthermore, the strategy was successfully applied to late-stage modification of complex drug-like molecules. Additionally, the corresponding 1-deuterium-glycals were produced easily by simple

A series of novel arylamine-substituted phenyl-phosphachromones were constructed via post-functionalization. As a new type of D–π–A functional molecule, their photophysical properties can be well tuned by different amino substituents at different positions with variable Stokes shifts (Δλ = 127–299 nm). Moreover, compounds 4a, 4b, 4f, 4m, and 4n exhibit an unusual dual emission with a large wavelength difference. Strong intermolecular interactions were also observed for these compounds, and therein, a sandwich π(donor)–π(donor) stacking interaction was found in the solid-state structure of 4e. Moreover, (TD-)DFT computations were performed to rationalize the observed electronic properties and intramolecular interactions. Finally, the delayed fluorescence of these D–π–A molecules in the film was observed and further confirmed to be a result of thermally activated delayed fluorescence and mixed room-temperature phosphorescence.

A novel, efficient and metal-free cascade sulfonylation/cyclization of 2-propynolphenols with commercially available sodium sulfinates was developed for the synthesis of 4-sulfonyl 2H-chromenes under mild conditions. The reaction occurred by the sodium sulfinates’ nucleophilic addition of the allylene carbocation intermediate followed by a 6-endo-trig pathway. Additionally, this approach avoids the use of an oxidant or a photo-radical inducer and the reaction can tolerate a wide variety of functional groups in good yields.

A novel and efficient strategy for the synthesis of 4-chloro quinolines via the TMSCl-mediated cascade cyclization of easily prepared ortho-propynol phenyl azides is developed. This reaction proceeds smoothly in moderate to excellent yields with a wide range of substrate compatibility. TMSCl acted not only as a promoter, but also as a chloro source in this transformation. Moreover, the obtained 4-chloro quinolines could be further derivated in an array of palladium-catalyzed coupling and nucleophilic substitution reactions to construct potential biologically active and pharmaceutical molecules.

In the present paper, we report a novel strategy for highly efficient stereoselective synthesis of 2′-modified nucleosides by using ortho-alkynyl benzoate as neighboring participation group. Subsequently, ortho-alkynyl benzoate can be removed smoothly in the presence of 5 mol% Ph3PAuCl–AgOTf in dichloromethane with H2O (1 eq.) and ethanol (6 eq.) to afford 2′-OH nucleosides in high yields and selectivity.