1. Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells
- Author
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Miroslav Hájek, Martin Hruby, Jitka Slegerova, Petr Cigler, Frantisek Sedlak, Ivan Rehor, and Jan Stursa
- Subjects
Materials science ,Cell Survival ,media_common.quotation_subject ,Integrin ,Nanoparticle ,Biocompatible Materials ,Nanotechnology ,Peptides, Cyclic ,Nanodiamonds ,chemistry.chemical_compound ,Cell Line, Tumor ,Humans ,Methacrylamide ,General Materials Science ,Internalization ,Fluorescent Dyes ,media_common ,Acrylamides ,Microscopy, Confocal ,biology ,Glioma ,Integrin alphaVbeta3 ,Silicon Dioxide ,Fluorescence ,Endocytosis ,chemistry ,Cell culture ,Cancer cell ,Click chemistry ,biology.protein ,Biophysics ,Click Chemistry - Abstract
Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin αvβ3 receptors on glioblastoma cells with high internalization efficacy.
- Published
- 2015
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