1. Fluorogenic probes to monitor cytosolic phospholipase A2 activity
- Author
-
Chian-Ming Low, Cheng Yang Ng, Yulin Lam, Francis Chee Kuan Tan, and Timothy Xiong Wei Kwok
- Subjects
0301 basic medicine ,chemistry.chemical_classification ,Metals and Alloys ,Substrate (chemistry) ,Nanotechnology ,General Chemistry ,Fluorescence ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,chemistry ,Materials Chemistry ,Ceramics and Composites ,Biophysics ,Cytosolic phospholipase A2 activity ,Arachidonic acid ,030217 neurology & neurosurgery ,Alkyl - Abstract
Arachidonic acid derivatives equipped with either one or two fluorescent groups attached to the tip of the alkyl chains were synthesized and shown to function as inhibitor and substrate probes of cPLA2. The inhibitor probe was demonstrated to perform dual functions of inhibition and imaging while the substrate probe could be used for activity assay.
- Published
- 2017
- Full Text
- View/download PDF