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A highly efficient ligand free catalytic system was developed for chemoselective transfer hydrogenation of α,β-unsaturated carbonyl compounds by palladium nanoparticles (PdNPs) in an aqueous reaction medium. The developed methodology offers chemoselective 1,4-reduction of various α,β-unsaturated carbonyl compounds such as carbonyls, amides, esters and nitriles with excellent chemoselectivity and effective catalyst recyclability.

A highly efficient polymer supported palladium-N–heterocyclic carbene (PS-Pd–NHC) catalytic system has been developed for direct reductive amination (DRA) of carbonyl compounds with primary/secondary amines in aqueous reaction medium. This new catalytic system represents a heterogeneous, recyclable and environmentally benign protocol. The developed methodology describes a simple one step approach for the synthesis of a wide variety of substituted amines exhibiting remarkable activity with excellent yield of a desired product. Furthermore, the catalyst was effectively recycled for six consecutive cycles without any significant loss in its catalytic activity.

An highly efficient PS-Pd-NHC catalytic system has been developed for chemoselective conjugate reduction of α,β-unsaturated carbonyl compounds providing good to excellent conversion with remarkable chemoselectivity (up to 100%). The developed protocol is more advantageous due to use of HCOONa as hydrogen source, environmentally benign water as solvent and effective catalyst recyclability.