1. Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues
- Author
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Alexandra Anderson, David J. Mann, Sarah E. Lee, Lucy M. Elphick, Véronique Gouverneur, Guy T. Giuffredi, Emma S. Child, and Laurent Bonnac
- Subjects
Ethylene ,Halogenation ,Chemistry ,Stereochemistry ,Butanols ,Organic Chemistry ,Nucleosides ,Stereoisomerism ,Primary alcohol ,Biochemistry ,Substrate Specificity ,Oxygen ,chemistry.chemical_compound ,Phosphorylation ,C nucleosides ,Physical and Theoretical Chemistry - Abstract
Enantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the tetrafluorinated ethylene group is compatible with O-phosphorylation of the primary alcohol, as demonstrated by the successful preparation of the tetrafluorinated naphthyl-C-nucleotide. © 2010 The Royal Society of Chemistry.
- Published
- 2010
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