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Start Over Author "McDonald AF" Publisher royal society of chemistry

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1 results on '"McDonald AF"'

1. Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography.

Author

Dickmann CGF, McDonald AF, Huynh N, Rigopoulos A, Liu Z, Guo N, Osellame LD, Gorman MA, Parker MW, Gan HK, Scott AM, Ackermann U, Burvenich IJG, and White JM

Subjects
Humans, Positron-Emission Tomography methods, Protein Domains, Proteins, Glioblastoma diagnostic imaging
Abstract

Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been targeted for molecular imaging of cancer. Here, we report the development of a novel molecule radiolabelled with positron emitting fluorine-18, [ 18 F]BiPET-2, and its in vitro and preclinical evaluation in glioblastoma models.

Published
2023
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