1. semiaza-Bambusurils are anion-specific transmembrane transporters.
- Author
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Khurana, Raman, Yang, Feihu, Khurana, Rishu, Liu, Junqiu, Keinan, Ehud, and Reany, Ofer
- Subjects
ORGANIC cation transporters ,ALKYL group ,ORGANIC anion transporters ,MEMBRANE lipids ,SULFIDES ,ANIONS - Abstract
semiaza-Bambus[6]urils efficiently transport anions across lipid membranes. A systematic modification of their lipophilic side chains to include various alkyl groups and thioethers reveals that the most efficient chloride transporters are those that agree with Lipinski's rule-of-lipophilicity, exhibiting clog P
o/w values close to 5. Furthermore, vesicle anion-transport assays show that the new anion-transporters are independent of the cation identity but exhibit high anion selectivity, NO3 − > Br− > Cl− > SO4 2− , in agreement with the Hofmeister series. These findings will allow for the design of highly specific anion transporters for biomedical applications, particularly for managing anion channelopathies. [ABSTRACT FROM AUTHOR]- Published
- 2022
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