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Your search keyword '"Gaulier C"' showing total 2 results
Start Over Author "Gaulier C" Publisher royal society of chemistry
2 results on '"Gaulier C"'

1. Access to functionalised silver(I) and gold(I) N-heterocyclic carbenes by [2 + 3] dipolar cycloadditions.

Author

Hospital A, Gibard C, Gaulier C, Nauton L, Théry V, El-Ghozzi M, Avignant D, Cisnetti F, and Gautier A

Abstract

A new strategy was developed for the modification of silver(I) and gold(I) N-heterocyclic carbenes. Azido groups were grafted and used either by copper-catalysed azide-alkyne cycloaddition before metallation or by thermal and "strain-promoted" 1,3-dipolar cycloaddition after metallation to functionalise the metal-NHCs.

Published
2012
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2. A water soluble Cu(I)-NHC for CuAAC ligation of unprotected peptides under open air conditions.

Author

Gaulier C, Hospital A, Legeret B, Delmas AF, Aucagne V, Cisnetti F, and Gautier A

Subjects
Amino Acid Sequence, Catalysis, Solubility, Air, Alkynes chemistry, Azides chemistry, Copper chemistry, Oligopeptides chemistry, Water chemistry
Abstract

A reducing agent-free version of CuAAC able to operate under open air conditions is reported. A readily-synthesizable, hydrophilic and highly stable Cu(I)-NHC allows the clean ligations of unprotected peptides comprising sensitive side chains, at millimolar concentrations.

Published
2012
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