Search

The destabilization and dysfunction of hypoxia-inducible factor 1 α (HIF-1α) caused by hyperglycemia are important reasons for delayed healing of diabetic chronic wounds. Hence, it is worth designing HIF-1α-stabilizing wound dressings to counteract the effects of a hyperglycemic microenvironment. Dimethyloxalylglycine (DMOG), a competitive inhibitor of prolyl hydroxylases (PHDs), can stabilize HIF-1α by inhibiting its degradation. Therefore, in this study, we developed DMOG releasing nanofibrous wound dressings for diabetic wound healing. We systematically evaluated the regulation of DMOG-releasing nanofibers on human foreskin fibroblasts (HFFs) with in vitro biological assessments. The results showed that the release of DMOG from nanofibers can be effectively controlled by the co-axial structure of nanofibers. The sustained release of DMOG in co-axial nanofibers enhanced the migration and expression of wound healing-related genes in HFFs. In addition, we conducted an in vivo study using a diabetic wound model in rat to examine the effects of DMOG-loaded nanofibrous wound dressings on the wound healing process. The in vivo study confirmed that the DMOG incorporated in nanofibers stabilized local HIF-1α levels in wounds and subsequently improved the diabetic wound regeneration by accelerating re-epithelialization, angiogenesis and wound closure, which was consistent with the in vitro evaluation. The results suggest that DMOG-releasing nanofibers may be promising functional wound dressings for diabetic wounds. [ABSTRACT FROM AUTHOR]

In Polymer Electrolyte Membrane Fuel Cells (PEMFCs) the thickness, structure and morphology of the electrode layer play an important role in the cell performance. This effect becomes particularly significant when the cathode catalyst is based on a non-precious metal due to the higher catalyst loadings required to compensate for the lower catalytic activity when compared to Pt based catalysts. In this study, an iron(iii) porphyrin framework material was synthesized and pyrolyzed and its catalytic activity towards the oxygen reduction reaction (ORR) was evaluated using rotating disk electrode (RDE) experiments and single cell testing. Single cell performance was evaluated as a function of the electrode catalyst loading (electrode thickness) and oxygen partial pressure. As expected, the ORR kinetic overpotential was the major contributor to the overall voltage loss. However, the mass transport contribution to the voltage loss became more prominent with small increases in the cathode catalyst loading. The observed performance is discussed in the context of structure and morphology of the catalyst layer (CL), analyzed through scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). [ABSTRACT FROM AUTHOR]

In this work, a self-powered photodetector device is fabricated through the integration of a palladium-doped molybdenum disulfide thin film on silicon (Pd-MoS2/Si). The substitution of host Mo atoms with Pd dopants in the MoS2 film is revealed by structural and chemical analysis techniques. Due to the incorporation of Pd atoms into the MoS2 films, the photovoltaic characteristics of the fabricated Pd-MoS2/Si device were enhanced largely, promoting its application as a self-powered photodetector operated at zero bias voltage. The obtained results further show that the device is highly sensitive to broadband wavelengths from ultraviolet to near-infrared light (300–1100 nm). In particular, the Pd-MoS2/Si photodetector shows an ultra-high detectivity of ∼1014 Jones (Jones = cm Hz1/2 W−1), a responsivity of ∼654.0 mA W−1, and an ultrafast response speed of ∼2.1 μs. The present work opens new avenues for developing high-performance photodetectors for optical communications and imaging techniques as well as optoelectronic circuits. [ABSTRACT FROM AUTHOR]

Eu2+ doped Sr2AlxSi5−xN8−x/3 red phosphors have been synthesized by a solid state reaction method, with the aim of improving their thermal quenching properties. The XRD patterns confirm that Al3+ can efficiently substitute Si4+ in the Eu2+ doped Sr2Si5N8 host. The crystal structure is studied by Rietveld refinement, selected-area electron diffraction (SAED) and solid-state NMR analysis. With an increase in x, the emission spectra show no obvious shift and the full width at half maximum (FWHM) increases from 86 to 94.2 nm. Remarkably, the thermal quenching properties are obviously improved as appropriate Al3+ substituted Si4+. The corresponding mechanism is discussed in detail based on the influence of size mismatch and the configurational coordinate model. [ABSTRACT FROM AUTHOR]

The chemical behaviors of alkali and alkaline earth metal hydrides including LiH, KH, MgH 2 , CaH 2 , and BaH 2 under nitrogen plasma differ significantly from one another, exhibiting an ammonia production trend that contrasts with that observed under thermal conditions. A prominent feature of KH is its ability to facilitate plasma-assisted N 2 fixation without generating H 2 byproduct, showing high atomic economy in utilization of hydride ions for N 2 reduction.

We design a multi-effective nanoplatform (CeO 2 :Nd@SiO 2 @CeO 2 :Yb,Er@SiO 2 -RB/MB/CD36) with down/upconversion dual-mode emissions and targeting ability in foam macrophages. Under NIR excitation, this nanoplatform can realize in vivo NIR-II imaging and PDT/PTT coordinated therapy for early AS simultaneously.

Photocatalytic CO 2 reduction captures solar energy to convert CO 2 into hydrocarbon fuels, thus shifting the dependence on rapidly depleting fossil fuels. Among the various proposed photocatalysts, systems containing metal active sites (MASs) possess obvious advantages, such as effective photogenerated carrier separation, suitable adsorption and activation of intermediates, and achievable C-C coupling to generate multi-carbon (C 2+ ) products. The present review aims to summarize the typical photocatalytic materials with MAS, highlighting the critical role of different formulations of MAS in CO 2 photoreduction, especially for C 2+ product generation. State-of-the-art progress in the characterization and theoretical calculations for MAS-containing photocatalysts is also emphasized. Finally, the challenges and prospects of catalytic systems involving MAS for solar-driven CO 2 conversion are outlined, providing inspiration for the future design of materials for efficient photocatalytic energy conversion., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

The inherent poor stability of CsPbI 3 nanocrystals hinders the practical application of this material. Therefore, it is still a challenge to improve the stability of CsPbI 3 nanocrystals and realize their large-scale continuous preparation. In this work, we report the preparation of CsPbI 3 /TiO 2 nanocomposites with high stability by a microfluidic method. After the combination of CsPbI 3 nanorods with TiO 2 , the PL intensity increased by 1.3 times under excitation at 577 nm due to the passivating effect of TiO 2 on the surface of CsPbI 3 nanorods and its carrier transport characteristics. Meanwhile, due to the coating of TiO 2 , the surface exposure area of CsPbI 3 nanorods is reduced, which blocks external environmental effects to some extent and effectively improves the stability of CsPbI 3 nanorods. Finally, an LED with a color gamut of 142% NTSC and a color temperature (CCT) of 3952 K was obtained by combining CsPbI 1.5 Br 1.5 /TiO 2 and CsPbBr 3 /TiO 2 nanocomposites with a blue light chip (455 nm). This study shows that the continuous and controllable synthesis of all inorganic halide perovskite nanocrystals by a microfluidic method is of great significance in the fabrication of high-performance optoelectronic materials and display devices.

Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), has the advantages of spatiotemporal selectivity, non-invasiveness, and negligible drug resistance. Phototherapy has been approved for treating superficial epidermal tumors. However, its therapeutic efficacy is limited by the hypoxic tumor microenvironment and the highly expressed heat shock protein. Moreover, poor tissue penetration and focused irradiation laser region in phototherapy make treating deep tissues and metastatic tumors challenging. Combination therapy strategies, which integrate the advantages of each treatment and overcome their disadvantages, can significantly improve the therapeutic efficacy. Recently, many combination therapy strategies have been reported. Our study summarizes the strategies used for combining phototherapy with other cancer treatments such as chemotherapy, immunotherapy, sonodynamic therapy, gas therapy, starvation therapy, and chemodynamic therapy. Some research cases were selected to analyze the combination therapy effect, delivery platform feature, and synergetic anticancer mechanisms. Moreover, additional research cases are summarized in the tables. This review provides strong evidence that phototherapy-based combination strategies can enhance the anticancer effect compared with phototherapy alone. Additionally, the challenges and future perspectives associated with these combinational therapies are discussed.

Developing electrocatalysts with high activity toward the hydrogen evolution reaction (HER) is a prerequisite for hydrogen fuel generation and sustainable development, but current Pt-based catalysts usually suffer from high cost and unsatisfactory performance in non-acidic media. In this work, we report an environmentally friendly and pyrolysis-free synthesis strategy to prepare an efficient catalyst, CNT-NPA-PtRu, with Pt single-atom engineered sub-nanometric Ru clusters anchored at phytic acid-modified carbon nanotubes for electrochemical HER at all pH conditions. The electronic structure of active sub-nanometric Ru clusters was optimized, which further enhanced the HER activity. The synthesized CNT-NPA-PtRu catalyst presents superior performance, reaching the current density of 10 mA cm -2 with only 18.3, 18.7 and 15 mV overpotential in alkaline, acidic and neutral electrolyte, respectively. Experimental results and theoretical calculations reveal that the single Pt atom on the sub-nanometric Ru cluster surface could modulate the electronic structure of Ru and subsequently optimize the adsorption of reaction intermediates, thus promoting HER performance. These findings underscore the importance of engineering the electronic structure of sub-nanometric clusters and offer an effective approach for the generation of high-performance electrocatalysts for HER., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Inflammatory bowel disease (IBD) is difficult to cure, and formulating a dietary plan is an effective means to prevent and treat this disease. Wheat peptide contains a variety of bioactive peptides with anti-inflammatory and antioxidant functions. The results of this study showed that preventive supplementation with wheat peptide (WP) can significantly alleviate the symptoms of dextran sulfate sodium (DSS)-induced colitis in mice. WP can increase body weight, alleviate colon shortening, and reduce disease activity index (DAI) scores. In addition, WP improved intestinal microbial disorders in mice with colitis. Based on LC-MS, a total of 313 peptides were identified in WP, 4 of which were predicted to be bioactive peptides. The regulatory effects of WP and four bioactive peptides on the Keap1-Nrf2 signaling pathway were verified in Caco-2 cells. In conclusion, this study demonstrated that WP alleviates DSS-induced colitis by helping maintain gut barrier integrity and targeting the Keap1-Nrf2 axis; these results provided a rationale for adding WP to dietary strategies to prevent IBD.

Liquid-free ionic conductive elastomers (ICEs) are ideal materials for constructing flexible electronic devices by avoiding the limitations of liquid components. However, developing all-solid-state ionic conductors with high mechanical strength, high ionic conductivity, excellent healing, and recyclability remains a great challenge. Herein, a series of liquid-free polyurethane-based ICEs with a double dynamic crosslinked structure are reported. As a result of interactions between multiple dynamic bonds (multi-level hydrogen bonds, disulfide bonds, and dynamic D-A bonds) and lithium-oxygen bonds, the optimal ICE exhibited a high mechanical strength (1.18 MPa), excellent ionic conductivity (0.14 mS cm -1 ), desirable healing capacity (healing efficiency >95%), and recyclability. A multi-functional wearable sensor based on the novel ICE enabled real-time and rapid detection of various human activities and enabled recognizing writing signals and encrypted information transmission. A triboelectric nanogenerator based on the novel ICE exhibited an excellent open-circuit voltage of 464 V, a short-circuit current of 16 μA, a transferred charge of 50 nC, and a power density of 720 mW m -2 , enabling powering of small-scale electronic products. This study provides a feasible strategy for designing flexible sensor products and healing, self-powered devices, with promising prospects for application in soft ionic electronics.

Herein, we present toxicological assessments of carbon nanomaterials in HL-7702 cells, and it was found that reactive oxygen species (ROS) levels were elevated. Mass spectrometry results indicated that cysteine sulfhydryl of glutaredoxin-1 (GLRX1) was oxidized to sulfenic acids and sulfonic acids by excessive ROS, which broke the binding of GLRX1 to apoptosis signal-regulating kinase 1, causing the activation of the JNK/p38 signaling pathway and ultimately hepatocyte apoptosis. However, a lower level of ROS upregulated GLRX1 instead of sulfonation modification of its active sites. Highly expressed GLRX1 in turn enabled the removal of intracellular ROS, thereby exerting inconspicuous toxic effects on cells. Taken together, these findings emphasized that CNM-induced hepatotoxicity is attributable to oxidative modifications of GLRX1 arising from redox imbalance.

Biomass-based hydrogels have displayed excellent potential in flexible strain sensors due to their adequacy, biocompatibility, nontoxic and degradability. Nevertheless, their inferior mechanical properties, particularly at cryogenic temperatures, impeded their extensive utilization. Herein, we reported a rationally designed strain sensor fabricated from a gelatin and cellulose-derived hydrogel with superior mechanical robustness, cryogenic endurance, and flexibility, owing to a triple dynamic bond strategy (TDBS), namely the synergistic reinforcement among potent hydrogen bonds, imine bonds, and sodium bonds. Beyond conventional sacrificing bonds consisting of hydrogen bonds, dynamic covalent bonds and coordinate bonds, synergetic triple dynamic bonds dominated by strong hydrogen bonds and assisted by imine and sodium bonds with higher strength can dissipate more mechanical energy endowing the hydrogel with 38-fold enhancement in tensile strength (6.4 MPa) and 39-fold improvement in toughness (2.9 MPa). We further demonstrated that this hydrogel can work as a robust and biodegradable strain sensor exhibiting remarkable flexibility, broad detection range, considerable sensitivity and excellent sensing stability. Furthermore, owing to the improved nonfreezing performance achieved from incorporating sodium salts, the sensor delivered outstanding sensing properties under subzero conditions such as -20 and -4 °C. It is anticipated that the TDBS can create diverse high-performance soft-electronics for broad applications in human-machine interfaces, energy and healthcare.

Designing wound dressings necessitates the crucial considerations of maintaining a moist environment and implementing effective bacterial control. Furthermore, developing a three-dimensional framework emulating the extracellular matrix (ECM) confers advantages in fostering cellular migration and proliferation. Inspired by this, hydrogel/nanofiber composites have been demonstrated as promising materials for wound dressings. The composites also overcome the disadvantages of poor mechanical properties and rapid release of traditional pure hydrogels. In this study, we constructed a calcium alginate hydrogel/polylactic acid nanofiber (CAH/PLANF) composite with an interpenetrated network. Additionally, the synthesis of zeolitic imidazolate framework-8 (ZIF-8) incorporated into the composite system endowed the system with enhanced mechanical properties and photodynamic antibacterial attributes. The obtained composite patch (ZIF-8@CAH/PLANF) exhibited excellent swelling, strong mechanical properties, low cytotoxicity, and durable photodynamic antibacterial effect with an antibacterial efficacy of higher than 99.99%. Finally, bacterial infection and wound healing properties were investigated in vivo , and the ZIF-8@CAH/PLANF patch was proven to have the ability to fight infection and accelerate wound healing.

Insulin resistance is closely related to many metabolic diseases and has become a serious public health problem worldwide. So, it is crucial to find its environmental pathogenic factors. Methyl tert -butyl ether (MTBE), a widely used unleaded gasoline additive, has been proven to affect glycolipid metabolism. However, results from population studies are lacking. For this purpose, the potential relationships between MTBE exposure and the triglyceride glucose (TyG) index, a useful surrogate marker of insulin resistance, were evaluated using a small-scale occupational population. In this study, 201 participants including occupational and non-occupational MTBE exposure workers were recruited from the Occupational Disease Prevention and Control Hospital of Huaibei, and their health examination information and blood samples with informed consent were collected. The internal exposure levels were assessed by detecting blood MTBE using solid-phase-micro-extraction gas chromatography-mass spectrometry. Then the adjusted linear regression model was used to assess the relationship between MTBE exposure and fasting plasma glucose (FPG), or TyG index. Then, receiver-operating-characteristic (ROC) curves were performed to calculate the optimal cut-off points. Multivariable and hierarchical logistic regression models were used to analyze the impact of MTBE exposure on the risk of insulin resistance. Obvious correlations were observed between blood MTBE levels with TyG index ( p = 0.016) and FPG ( p = 0.001). Further analysis showed that using the mean of the TyG index (8.77) as a cutoff value had a good effect on reflecting the risk of insulin resistance. Multivariable logistic regression analysis also indicated that MTBE exposure was an independent risk factor for a high TyG index (OR = 1.088, p = 0.038), which indicated that MTBE exposure might be a new environmental pathogenic factor leading to insulin resistance, and MTBE exposure might increase the risk of insulin resistance by independently elevating the TyG index in male gas station workers.

N - and O -glycosylation modifications of proteins are closely linked to the onset and development of many diseases and have gained widespread attention as potential targets for therapy and diagnosis. However, the low abundance and low ionization efficiency of glycopeptides as well as the high heterogeneity make glycosylation analysis challenging. Here, an enrichment strategy, using Knoevenagel copolymers modified with polydopamine-adenosine (denoted as PDA-ADE@KCP), was firstly proposed for simultaneous enrichment of N - and O -glycopeptides through the synergistic effects of hydrophilic and electrostatic interactions. The adjustable charged surface and hydrophilic properties endow the material with the capability to achieve effective enrichment of intact N - and O -glycopeptides. The experimental results exhibited excellent selectivity (1 : 5000) and sensitivity (0.1 fmol μL -1 ) of the prepared material for N -glycopeptides from standard protein digest samples. Moreover, it was further applied to simultaneous capturing of N - and O -glycopeptides from mouse liver protein digests. Compared to the commercially available zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC) material, the number of glycoproteins corresponding to all N - and O -glycopeptides enriched with PDA-ADE@KCP was much more than that with ZIC-HILIC. Furthermore, PDA-ADE@KCP captured more O -glycopeptides than ZIC-HILIC, revealing its superior performance in O -glycopeptide enrichment. All these results indicated that the strategy holds immense potential in characterizing N - and O -intact glycopeptides in the field of proteomics.

As an important chemical intermediate, aniline is primarily produced industrially through catalytic hydrogenation of nitrobenzene. Herein, a series of nitrogen-doped carbon materials (referred to as NCM- T , with T denoting the roasting temperature (°C)) were prepared through high-temperature roasting of sucrose and melamine for the heterogeneous catalytic liquid-phase hydrogenation of nitrobenzene to aniline. A preliminary study of the involved reaction mechanism was performed by combining the results of material characterisation and catalyst evaluation. Experimental results showed that the graphitic N content and the defective sites simultaneously affected the performance of NCM- T in catalysing the hydrazine hydrate reduction in the nitrobenzene hydrogenation reaction. The catalyst NCM-800 was reacted in an ethanol solution with hydrazine hydrate as the reducing agent at 80 °C for 5 h. Notably, the nitrobenzene conversion rate was up to 94%, and the aniline selectivity was 100%. The turnover frequency (TOF) could reach up to 7.9 mol g -1 h -1 , and after five recycling cycles, only a small loss of catalytic activity was observed. This shows that the prepared catalyst is a recyclable catalyst that can be used for reducing the nitrobenzene from hydrazine hydrate to aniline., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

The construction of highly active and stable transition phosphide-based materials is widely regarded as an alternative approach to the use of Pt-based catalysts in the field of electrocatalytic hydrogen evolution. Herein, self-supported heterostructure Co-Ni phosphides (denoted as Co x Ni 1- x -P) were synthesized with different metal ratios by a low temperature electrodeposition strategy. Impressively, the optimized heterogeneous Co 0.5 Ni 0.5 -P nanocomposites displayed outstanding hydrogen evolution performance, with low overpotentials of 67 mV and 181 mV to deliver current densities of 10 mA cm -2 and 100 mA cm -2 in alkaline electrolyte. X-ray photoelectron spectroscopy revealed the optimized electronic structure of Co 0.5 Ni 0.5 -P, which led to an improvement in the conductivity. Density functional theory calculations demonstrated that the Co 0.5 Ni 0.5 -P heterostructure could provide a more optimal water-dissociation-related Volmer process for hydrogen evolution reaction (HER), in which water molecules could be easily activated on Co 0.5 Ni 0.5 -P with a low energy barrier. Moreover, the downshift of the d-band center confirmed the optimized H adsorption, further accelerating the HER kinetics.

The electrochemiluminescence (ECL) behavior of a tri(2,2'-bipyridyl)ruthenium(ii) (Ru(bpy) 3 2+ )/tripropylamine (TPrA) system was investigated in sensor chips with two kinds of integrated two-electrode systems, which included screen-printed electrodes (SPE) and physical vapor deposition (PVD) electrodes. Firstly, under excitation with an optimal transient potential (TP) within 100 ms, the ECL assay could be carried out on the microchips using an Au & Au electrode system, emitting strong and stable light signal. Secondly, on the PVD chip, the ECL intensity initiated by optimal TP was eight times stronger than the peak light signal emitted by the linear sweep voltammetry model. Finally, the logarithmic ECL intensities exhibited a linear increase with the logarithmic concentrations of Ru(bpy) 3 2+ in both the SPE and PVD chips without any reference electrode (RE). Typically, the integration of an interdigital two-electrode system in the microchip significantly enhanced the ECL sensitivity of Ru(bpy) 3 2+ because the large relative area between the working electrode (WE) and counter electrode (CE) achieved a highly efficient mass transfer. This improvement enabled the establishment of a reliable linear relationship across a wide concentration range, spanning from 1 pM to 1 μM ( R 2 = 0.998). Therefore, the exceptional ECL response of the Ru(bpy) 3 2+ /TPrA system on microfluidic chips using a two-electrode system and the TP excitation model has been demonstrated. This suggests that ECL chips without a RE have broad potential for the rapid and sensitive detection of multiple targets., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

The seamless integration of two-dimensional (2D) ferromagnetic materials with similar or dissimilar materials can widen the scope of low-power spintronics. In this regard, a vertical van der Waals (vdW) heterostructure of 2D ferromagnets with semiconducting transition metal dichalcogenides (TMDCs) forms magnetic junctions with exceptional stability and electrical control. Interestingly, 2D metallic Fe 3 GeTe 2 (FGT) reveals above room temperature Curie temperatures and has large magneto anisotropy due to spin-orbit coupling. In addition, it also possesses topological states and a large Berry curvature. Herein, we designed the FGT/WSe 2 /FGT vdW heterostructure with a uniform and sharp interface so that FGT could maintain its inherent electronic properties. Also, the uniform thickness of the barrier provides a smooth flow of spins through the junctions as tunneling exponentially decays with an increasing barrier thickness. However, strong energy-dependent spin polarization is crucial for achieving optimum spin valve properties, such as large tunneling magnetoresistance (TMR) along with the manipulation of the magnitude and sign reversal. We have observed a shifting of high-energy localized minority spin states toward low-energy regions, which causes spin polarization fluctuation between -42.5% and 41% over a wide range of bias voltage. This leads to a negative TMR% of ∼-100% at 0.1 V Å -1 and also a large positive TMR% at 0.2 V Å -1 and -0.4 V Å -1 . Besides, the system exhibits a highly tunable large anomalous Hall conductivity (AHC) of 626 S cm -1 . Interestingly, such unprecedented electronic behaviour with large and switchable spin polarization, anomalous Hall conductivity and TMR can be incorporated into MTJ devices, which provide electrical control and long-range spin transport. Additionally, the system emerges as a standout candidate in low-power spintronic devices ( e.g. , MRAM and magnetic sensors) owing to its distinctive energy-dependent electronic structure with a wide range of external bias.

Acid-catalyzed intramolecular cyclization or rearrangement of isoindolinone derivatives is described. 3-Hydroxy/ethoxy-3,4-dihydro-6 H -[1,4]-oxazino-[3,4- a ]-isoindol-6-ones are obtained in moderate to good yields. Further acid-catalyzed intramolecular rearrangement reactions give 6 H -isochromeno-[4,3- b ]-pyridin-6-ones. The mild reaction conditions with convenient starting materials show broad substrate scope and provide the target compounds as novel pesticide leads with good fungicidal or systemical acquired resistance activities.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease pathologically caused by amyloid-β protein (Aβ) aggregation, oxidative stress, and neuroinflammation. The pathogenesis of AD is still uncertain and intricate, and helpful therapy has rarely been recorded. So, discovering amyloid modulators is deemed a promising avenue for preventing and treating AD. In this study, human serum albumin (HSA), a protein-based Aβ inhibitor, was utilized as a template to guide the synthesis of HSA-manganese dioxide nanocomposites (HMn NCs) through biomineralization. The in situ formed MnO 2 in HSA endows this nano-platform with outstanding reactive oxygen species (ROS) scavenging capability, including superoxide dismutase-mimetic and catalase-mimetic activities, which could scavenge the plethora of superoxide anion radicals and hydrogen peroxide. More importantly, the HMn NCs show enhanced potency in suppressing Aβ fibrillization compared with HSA, which further alleviates Aβ-mediated SH-SY5Y neurotoxicity by scavenging excessive ROS. Moreover, it is demonstrated that HMn NCs reduce Aβ-related inflammation in BV-2 cells by lowering tumor necrosis factor-α and interleukin-6. Furthermore, transgenic C. elegans studies showed that HMn NCs could remove Aβ plaques, reduce ROS in CL2006 worms, and promote the lifespan extension of worms. Thus, HMn NCs provide a promising tactic to facilitate the application of multifunctional nanocomposites in AD treatment.

Microbes are usually present as a specific microbiota, and their classification remains a challenge. MALDI-TOF MS is particularly successful in library-based microbial identification at the species level as it analyzes the molecular weight of peptides and ribosomal proteins. FT-IR allows more accurate classification of bacteria at the subspecies level due to the high sensitivity, specificity and repeatability of FT-IR signals from bacteria, which is not achievable with MALDI-TOF MS. Previous studies have shown that more accurate identification results can be obtained by the fusion of FT-IR and MALDI-TOF MS spectral data. Here, we constructed 20 groups of model microbiota samples and used FT-IR, MALDI-TOF MS, and their fusion data to classify them. Hierarchical clustering analysis (HCA) showed that the classification accuracy of FT-IR, MALDI-TOF MS, and the fusion data was 85%, 90%, and 100%, respectively. These results indicate that both FT-IR and MALDI-TOF MS can effectively classify specific microbiota, and the fusion of their spectral data could improve the classification accuracy. The FT-IR and MALDI-TOF MS data fusion strategy may be a promising technology for specific microbiota classification.

Ultrawide-bandgap semiconductors, possessing bandgaps distinctly larger than the 3.4 eV of GaN, have emerged as a promising class capable of achieving deep ultraviolet (UV) light detection. Based on first-principles calculations, we propose an unexplored two-dimensional (2D) InTeClO 3 layered system with ultrawide bandgaps ranging from 4.34 eV of bulk to 4.54 eV of monolayer. Our calculations demonstrate that 2D InTeClO 3 monolayer can be exfoliated from its bulk counterpart and maintain good thermal and dynamic stability at room temperature. The ultrawide bandgaps may be modulated by the small in-plane strains and layer thickness in a certain range. Furthermore, the 2D InTeClO 3 monolayer shows promising electron transport behavior and strong optical absorption capacity in the deep UV range. A two-probe InTeClO 3 -based photodetection device has been constructed for evaluating the photocurrent. Remarkably, the effective photocurrent (5.7 A m -2 at photon energy of 4.2 eV) generation under polarized light has been observed in such a photodetector. Our results indicate that 2D InTeClO 3 systems have strong photoresponse capacity in the deep UV region, accompanying the remarkable polarization sensitivity and high extinction ratio. These distinctive characteristics highlight the promising application prospects of InTeClO 3 materials in the field of deep UV optoelectronics.

Considering the demand for device miniaturization, low-dimensional materials have been widely employed in various fields due to their unique and fascinating physical and chemical properties. Here, based on first-principles calculations, we predict a novel one-dimensional (1D) RhTe 6 I 3 chain system. Our calculations indicate that a 1D RhTe 6 I 3 single chain can be prepared from its bulk counterpart by an exfoliation method and exists stably at room temperature. The 1D RhTe 6 I 3 single chain is a direct semiconductor with a moderate bandgap of 1.75 eV under a strong spin-orbital coupling (SOC) effect dominated by Te. This bandgap can be modulated by the chain number and the application of external strain. Notably, the 1D RhTe 6 I 3 single chain has a high electron mobility (1093 cm 2 V -1 s -1 ), which is one to two orders of magnitude higher than those of most previously reported 1D materials. The strong SOC effect can also enhance the visible-light absorption capacity of the 1D RhTe 6 I 3 single chain. The moderate direct bandgap, high electron mobility, excellent visible-light absorption, and strong spin-orbital coupling make 1D RhTe 6 I 3 systems ideal candidates in electronic and optoelectronic devices.

Despite the popularity of ion mobility spectrometry (IMS) for glycan analysis, its limited structural resolution hinders the effective separation of many glycan isomers. This leads to the overlap of IMS peaks, consequently impacting the accurate identification of glycan compositions. To this end, an improved algorithm, namely second-order differentiation combined with a simulated annealing particle swarm optimization algorithm based on sine adaptive weights (DWSA-PSO), was proposed for the separation of overlapping IMS peaks formed by glycan isomers. DWSA-PSO first performed second-order differentiation to automatically determine the number of components in overlapping peaks and exclude impossible single-peak combinations. It then introduced sinusoidal adaptive weights and a simulated annealing mechanism to improve the algorithm's search capability and global optimization performance, thereby enabling accurate and efficient separation of individual peaks. To evaluate the performance of DWSA-PSO and its application to the separation of glycan isomers, multiple sets of overlapping peaks with different degrees of overlap were simulated, and various types of multi-component overlapping peaks were formed using six disaccharide and four trisaccharide isomers. The experimental results consistently demonstrated that the DWSA-PSO algorithm outperformed both the improved particle swarm optimization (IPSO) algorithm and the dynamic inertia weight particle swarm optimization (DIWPSO) algorithm in terms of separation accuracy, running time, and fitness values. In addition, the DWSA-PSO algorithm was successfully applied to the separation of glycan isomers in malt milk beverage. All these results reveal the capability of the DWSA-PSO algorithm to facilitate the accurate identification of glycan isomers.

Ginkgo seed has potential applications in the prevention and treatment of hypertension, but its application in food is limited. Thus, ginkgo seed globulin was hydrolyzed using dual enzymes (Alcalase and thermolysin). After gel column separation, reverse-phase high-performance liquid chromatographic purification, and ESI-MS/MS analysis, five oligopeptides containing fewer than 12 amino acid residues were obtained. Among them, the heptapeptide Glu-Ala-Ser-Pro-Lys-Pro-Val (EASPKPV) offered relatively high capacities to inhibit ACE (IC 50 : 87.66 μmol L -1 ) and bind with zinc ions (5.35 ± 0.32 mg g -1 ). Moreover, EASPKPV showed competitive inhibitory kinetics against ACE. Fourier-transform infrared spectroscopy analysis evidenced that the amino group and carboxyl group of EASPKPV could both provide binding sites for zinc ions. EASPKPV can restrain ACE in the following ways: (i) competitively linking with five key residues (Gln281, Ala354, Glu376, Lys511, and Tyr523) in the S1 and S2 pockets of ACE by short hydrogen bonds; (ii) binding to thirteen active residues of ACE via hydrophobic interactions; and (iii) binding with residue His383 or the zinc ion of zinc tetrahedral coordination. Additionally, simulated gastrointestinal digestion did not show any remarkable efficacy on the capacities of EASPKPV to restrain ACE and bind with zinc ions. These results indicate that ginkgo peptides may be used for antihypertension., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Experimental observations revealed that the amyloid-β 42 oligomer (AβO) can directly bind to the LilrB2 D1D2(LDD) receptor with nanomolar-affinity, leading to changes in synaptic plasticity and cognitive deficits. However, the dependence of neurotoxicity on the morphology, size, and aggregation stage (SP1, SP2) of AβO, as well as the specific molecular mechanism of AβO-LDD interaction, remain uncertain. To address these uncertainties, we investigated the interaction between the LDD neuroreceptor and AβO with different Aβ42 species (nontoxic species, toxic species, and protofibril) and sizes. Our results showed that the LDD selectively binds AβO species rather than the Aβ42 monomer, accommodating various Aβ42 dimers and trimers as well as SP2 AβO, in a specific pose in the pocket of the LDD receptor (region I). Additionally, protofibrils with exposed β1/β2 regions can also bind to region I of the LDD receptor, as observed experimentally (Cao, et al. , Nat. Chem. , 2018, 10 , 1213; and Aim et al. , Nat. Commun. , 2021, 12 , 3451). More extensively, we identified two additional regions of the LDD receptor, regions II and III, suitable for binding to larger AβO species at the SP1 with different molecular weights and conformations, accounting for the stronger binding strength obtained experimentally. We suggest that the two regions are more competitive than region I in causing toxicity by AβO binding. The detailed and systematic characterization for the complexes generated between the LDD receptor and various AβO species, including the protofibril, offers deep insight into the dependence of neurotoxicity on the AβO size and conformation at the molecular level, and provides novel and specific targets for drug design of Alzheimer's disease.

All-inorganic cesium lead bromide (CsPbBr 3 ) quantum dots (QDs) with high photoluminescence (PL) quantum efficiency have been reported as ideal gain materials for high-performance lasers. Nevertheless, isolated CsPbBr 3 QDs have not achieved lasing emission (LE) due to finite absorption cross-section. Here, we demonstrate continuous-wave lasing of isolated CsPbBr 3 QDs embedded in a microcavity. Distributed Bragg reflectors (DBRs), together with isolated CsPbBr 3 QDs in a polymer matrix, are introduced to construct a vertical-cavity surface-emitting laser (VCSEL), which exhibits stable single-mode lasing emissions with an ultra-low threshold of 8.8 W cm -2 and a high Q factor of 1787. Such perovskite-based microcavity structures sustain highly stable excitons at room temperature and can provide an excellent experimental platform to further study the single-particle nano-lasers and quantum physics frontiers such as exciton-polariton condensation, single-photon emission, and optical quantum communication.

Droplet manipulation on superhydrophobic surfaces (DMSS) without conventional pipetting is an emerging liquid handling technology, which can be potentially used for diagnostic, analysis, and synthetic processes. Despite notable progress, controlling droplet motion on superhydrophobic surfaces by contactless acoustic waves is rarely reported. Herein, we report a contactless acoustic tweezer (CAT) for DMSS based on establishing ultrasonic standing wave between an ultrasound transducer (UST) and a superhydrophobic substrate to manipulate droplets without physical contact. The CAT utilizes acoustic radiation forces to trap and move droplets on superhydrophobic surfaces, which allows for precise and controllable movement of droplets by controlling the movement of the UST. Small droplets with volume less than 20 μL can be levitated in mid-air for out-plane manipulation, and large droplets with volume up to 500 μL can be trapped for in-plane manipulation. Experimental results demonstrate the versatility of the CAT for manipulating droplets with various compositions and volumes on various superhydrophobic substrates, offering a versatile and cross-contamination-free liquid handling approach for applications, including but not limited to high-throughput surface-enhanced Raman scattering.

Platinum-group metal (PGM) nanostructures with peroxidase-like catalytic activities ( i.e. , peroxidase mimics) have been actively developed and applied to in vitro diagnostics in recent years. This article provides our viewpoints on this emerging field from the perspectives of materials science and solid-state chemistry angles. We start with an introduction to PGM peroxidase mimics, their catalytic efficiencies, and insights into catalysis from computational simulations. We then discuss chemical approaches to the synthesis of PGM peroxidase mimics with desired physicochemical parameters and catalytic properties. Then, we elaborate on general methods for functionalizing the surfaces of PGM mimics with bioreceptors. Thereafter, we highlight the applications of PGM mimics in in vitro diagnostics, emphasizing the interactions of PGM mimics with other components of a diagnostic system. We conclude this article with our opinions on the challenges and opportunities in this field.

Nitric oxide (NO), as a critical transcellular messenger, participates in a variety of physiological and pathological processes. However, its real-time detection still faces challenges due to its short half-life and trace amounts. Here, MWCNTs@COF-366-Co was prepared by in situ growth of a cobalt porphyrin-based covalent organic framework (COF-366-Co) on multi-walled carbon nanotubes (MWCNTs), and a unique biosensing platform for ultrasensitive real-time NO determination was established. Remarkably, MWCNTs@COF-366-Co contains plenty of atomically arranged M-N 4 active sites for electrocatalysis, which provides more efficient electron transfer pathways and resolves the random arrangement issue of active sites. COF-366-Co with a high surface area contains a large number of exposed active M-N 4 sites, providing faster NO transport/diffusion and more efficient electron transfer pathways. Due to the synergy of atomic-level periodic structural features of COF-366-Co and high conductivity of MWCNTs, the MWCNTs@COF-366-Co electrochemical biosensor exhibited excellent NO determination performance in a wide range from 0.09 to 400 μM, with high sensitivity (8.9 μA μM -1 cm -2 ) and a low limit of detection (16 nM). Moreover, the biosensor has been successfully used to sensitively monitor NO molecules released from human umbilical vein endothelial cells (HUVECs). This research not only designed a multifunctional intelligent biosensor platform, but also provided a broad prospect for continuous dynamic monitoring of the activity of living cells and their released metabolites.

Fibrous aggregates of beta-amyloid (Aβ) is a hallmark of Alzheimer's disease (AD). Several major strategies of drugs or inhibitors, including neutral molecules, positive or negative ions, and dual-inhibitor, are used to inhibit the misfolding or aggregation of Aβ42, among which a kind of dual-inhibitor composed of a pair of positive and negative ions is emerging as the most powerful candidate. This knowledge lacks the origin of the strong inhibitory effect and synergy mechanisms blocking the development and application of such inhibitors. To this end, we employed 1 : 1 ionic pairs (IP) of oppositely charged benzothiazole molecules (+)BAM1-EG 6 (Pos) and (-)BAM1-EG 6 (Neg) as well as equimolar neutral BAM1-EG 6 (Neu) counterpart at two pH conditions (5.5 and 7.0) to bind Aβ42 targets, Aβ42 monomer (AβM), soluble pentamer (AβP), and pentameric protofibril (AβF) models, respectively, corresponding to the products of three toxic Aβ42 development pathways, lag, exponential and fibrillation phases. Simulated results illustrated the details of the inhibitory mechanisms of IP and Neu for the AβY (Y = M, P, or F) in the three different phases, characterizing the roles of Pos and Neg of IP as well as their charged, hydrophobic groups and linker playing in the synergistic interaction, and elucidated a previously unknown molecular mechanism governing the IP-Aβ42 interaction. Most importantly, we first revealed the origin of the stronger binding of IP inhibitors to Aβ42 than that of the equimolar neutral counterparts, observing a perplexing phenomenon that the physiological condition (pH = 7.0) than the acidic one (pH = 5.5) is more favorable to the enhancement of IP binding, and finally disclosed that solvation is responsible to the enhancement because at pH 7.0, AβP and AβF act as anionic membranes, where solvation plays a critical role in the chemoelectromechanics. The result not only provides a new dimension in dual-inhibitor/drug design and development but also a new perspective for uncovering charged protein disaggregation under IP-like inhibitors.

Hydrodeoxygenation (HDO) is an indispensable approach to produce renewable biofuels and value-added chemicals using natural biomass and its derivatives. 2,5-Dimethylfuran (DMF) is considered to be a very promising liquid biofuel, and it can be fabricated by HDO of the biomass derivative 5-hydroxymethylfurfural (HMF). Herein, a highly efficient bifunctional catalyst, Co/HAP(Ce), was fabricated by anchoring highly dispersed Co on Ce-doped hydroxyapatite (HAP(Ce)). Co/HAP(Ce) displayed excellent HDO catalytic activity to convert HMF to DMF, and 99% HMF conversion and 96% DMF selectivity can be obtained under 150 °C, 2 MPa H 2 conditions for 5 h. Density functional theory calculations revealed that H 2 can be more easily activated by Co/HAP(Ce). Systematic studies confirmed that the high activity of Co/HAP(Ce) can be ascribed to the desired acid-alkali properties, highly dispersed cobalt species and strong metal-support interactions. This research provides a cost effective approach for designing efficient catalysts for HDO of biomass and its derivatives.

In this work, the nanoindentations on bilayer composite nanofilms composed of metal Ag and polymer PMMA were simulated using molecular dynamics. The effects of the thickness of Ag and PMMA on the elastic moduli of the composite films were analyzed from Hertz contact theory, dislocation evolution and atomic migration. The results show that the maximum penetration depth that the Hertz model could well describe is about 6 Å, and this limiting value is almost independent on the film thickness. The deformation mode of the Ag films gradually changes from bending mode to indentation mode with an increase in Ag thickness, which improves the elastic modulus of the composite films. The rule of mixtures could give a theoretical prediction about the elastic modulus of the composite film close to the nanoindentation, and Hertz theory could also be used as long as the thickness of Ag films exceeded a certain value. The introduction of a PMMA layer impedes the development of dislocation in the Ag layer and improves the elastic limit of the composite films. This work provides an important basis for experimentally measuring the overall elastic modulus of metal/polymer composite film based on nanoindentation or extracting the elastic modulus of metal film from the overall indentation response of the composite film., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Morphing in creatures has inspired various synthetic polymer materials that are capable of shape shifting. The morphing of polymers generally relies on stimuli-active (typically heat and light active) units that fix the shape after a mechanical load-based shape programming. Herein, we report a strategy that uses a mechanochemically active 2,2'-bis(2-phenylindan-1,3-dione) (BPID) mechanophore as a switching unit for mechanochemical morphing. The mechanical load on the polymer triggers the dissociation of the BPID moiety into stable 2-phenylindan-1,3-dione (PID) radicals, whose subsequent spontaneous dimerization regenerates BPID and fixes the temporary shapes that can be effectively recovered to the permanent shapes by heating. A greater extent of BPID activation, through a higher BPID content or mechanical load, leads to higher mechanochemical shape fixity. By contrast, a relatively mechanochemically less active hexaarylbiimidazole (HABI) mechanophore shows a lower fixing efficiency when subjected to the same programing conditions. Another control system without a mechanophore shows a low fixing efficiency comparable to the HABI system. Additionally, the introduction of the BPID moiety also manifests remarkable mechanochromic behavior during the shape programing process, offering a visualizable indicator for the pre-evaluation of morphing efficiency. Unlike conventional mechanical mechanisms that simultaneously induce morphing, such as strain-induced plastic deformation or crystallization, our mechanochemical method allows for shape programming after the mechanical treatment. Our concept has potential for the design of mechanochemically programmable and mechanoresponsive shape shifting polymers., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

The hydrogen evolution reaction (HER) plays a vital role for the production of pure hydrogen with zero carbon release. Developing high efficiency non-noble metal electrocatalysts could reduce its cost. Here, vanadium doped cobalt phosphide grown on carbon cloth (CC) was synthesized by the low temperature electrodeposition-phosphorization method. The influence of V dopants on the structural, morphological, and electrocatalytic performance of V x -Co 1- x -P composites was also investigated in-depth. Impressively, the optimized amorphous V 0.1 -Co 0.9 -P nano-electrocatalyst exhibits outstanding catalytic activity with a low overpotential of 50 mV at a current density of 10 mA cm -2 and a small Tafel value of 48.5 mV dec -1 in alkaline media. The results showed that V dopants in the composite change its crystal structure from the crystalline phase to the amorphous phase, resulting in the introduction of V-O sites, which regulate the electron density of the active sites and the exposure of surface active sites and thus promote the electrocatalytic HER process. This work provides a novel idea for the fabrication of high-efficiency metal phosphide based electrocatalysts.

In this study, the potential application of expanded vermiculite (EVM) as the supporting material and capric-palmitic acid (CA-PA) binary eutectic as the adsorbent mixture to fabricate a form-stable composite CA-PA/EVM by a vacuum impregnation method was investigated. The prepared form-stable composite CA-PA/EVM was then characterized by scanning electronic microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TG), differential scanning calorimetry (DSC) and a thermal cycling test. The maximum loading capacity and melting enthalpy of CA-PA/EVM could reach 51.84% and 67.5 J g -1 . Meanwhile, the thermal physical and mechanical properties of the CA-PA/EVM-based thermal energy storage mortars were examined to determine if the composite material based on the newly invented CA-PA/EVM material can be employed for energy conservation and efficiency in the building field. In addition, the law of full-field deformation evolution of CA-PA/EVM-based thermal energy storage mortar under uniaxial compression failure was studied based on digital image correlation (DIC) technology, which provides certain guiding significance for the application of CA-PA/EVM-based thermal energy storage mortars in practical engineering., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Whilst metal borates are well known as optical materials, their potential in solid catalysis has been less investigated. The calcite structured InBO 3 was selected as the target borate and was prepared using a solvothermal method. High-resolution transmission electron microscopy and powder X-ray diffraction prove that the material has a nanoparticle morphology with an average size ∼50 nm and high crystallinity. Intrinsic surface oxygen vacancies, which are beneficial to catalysis, were detected using X-ray photoelectron spectroscopy. Lewis acidity and basicity were both observed using NH 3 -/CO 2 -temperature-programmed desorption experiments, and the total acid and base amounts were found to be 46.6 and 123.8 μmol g -1 , respectively. Catalytic dehydration and dehydrogenation reactions for isopropanol at elevated temperatures were conducted in a fixed bed reactor to evaluate the catalytic performance of InBO 3 . InBO 3 exhibits a high conversion rate (>90.5%) and, most importantly, a high dehydrogenation selectivity (acetone selectivity >92.5%), whilst the optimal acetone yield achieved was 121.3 mmol h -1 g -1 cat at 350 °C. This study on InBO 3 strongly suggests that metal borates have promising applications in heterogeneous catalysis.

Thermal diffusion of particles in dilute aqueous suspensions is driven by the interactions between the dispersing medium and the particle, which are largely influenced by the properties of the medium. Using a commercial instrument to generate thermophoresis, we developed a method to quantify the migration of colloids in a temperature gradient and further studied how it varies based on the composition and pH of the dispersing medium and with an anionic surfactant, at different salt concentrations. Thermophoretic migration of aqueous suspensions of carboxylate-modified polystyrene particles with different compositions is measured as MicroScale Thermophoresis (MST) traces and a mathematical model is developed to extract the Soret coefficient ( S T ). Soret coefficient measurements obtained using the developed method are in-line with previous theories and scientific findings from other literature, indicating a dependence of the S T on the Debye length and surface charge density of the suspended particles, both of which are controlled by the composition of the dispersing medium. The thermophobic/thermophilic behavior of particles is also found to be strongly influenced by the thermoelectric effect of the buffer ions. In this paper, a new analytical model is introduced and applied to complex systems to understand their thermophoretic behavior as a function of solvent properties., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)