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Your search keyword '"Chen, Pu‐Guang"' showing total 3 results
Start Over Author "Chen, Pu‐Guang" Publisher royal society of chemistry
3 results on '"Chen, Pu‐Guang"'

1. Uncovering the pathological functions of Ser404 phosphorylation by semisynthesis of a phosphorylated TDP-43 prion-like domain.

Author

Li, Qian-Qian, Liu, Yu-Qing, Luo, Yun-Yi, Chu, Ting-Ting, Gao, Na, Chen, Pu-Guang, Chen, Yong-Xiang, and Li, Yan-Mei

Subjects
PHOSPHORYLATION
Abstract

Herein, we have successfully semi-synthesized a TDP-43 prion-like domain with Ser404 phosphorylation. We have demonstrated that Ser404 phosphorylation could accelerate the amyloid aggregation of the TDP-43 prion-like domain and aggravate its cytotoxicity. [ABSTRACT FROM AUTHOR]

Published
2020
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2. Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines.

Author

Wu, Jun-Jun, Li, Wen-Hao, Chen, Pu-Guang, Zhang, Bo-Dou, Hu, Hong-Guo, Li, Qian-Qian, Zhao, Lang, Chen, Yong-Xiang, Zhao, Yu-Fen, and Li, Yan-Mei

Subjects
TARGETED drug delivery, CYCLIC compounds, INTERFERON genetics, IMMUNE response, GLYCOPEPTIDE synthesis, CANCER vaccines
Abstract

Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2′-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and contributed to high titers of IgG antibodies and the expression of multiple cytokines. [ABSTRACT FROM AUTHOR]

Published
2018
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