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Neural responses to sensory inputs can scale with the likelihood of encountering the input. This is consistent with the predictive coding framework, in that the human brain is expected to be less responsive to predicted inputs. Typically, however, prediction is not explicitly measured. It is inferred from the probability of encountering an event. When an input is explicitly predicted, responses to predicted inputs can be enhanced. Here, we ask if this effect can be ascribed to a generic priming effect, from pre-cogitating about one of two possible inputs. Consistent with this, we find that P300s (a relatively late event-related potential measured with electroencephalography) are greater for explicitly predicted audio and visual inputs, and that this effect cannot be distinguished from a priming effect from pre-imagining audio or visual presentations. Evidence indicates that participants engaged in pre-imagining presentations, as we were able to decode online what type of presentation (audio or visual) they were imagining with a high success rate (approx. 73%), and we encouraged compliance with neuro-feedback regarding this success rate. Our data confirm that human cortex can be more responsive to inputs that have been subject to pre-cogitation—including explicit predictions. This highlights that while anticipatory processes can reduce responding to likely inputs, they can also enhance responding to explicitly predicted inputs. [ABSTRACT FROM AUTHOR]