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This chapter describes the contribution of the operations management (OM) field to entrepreneurship and startup practices in terms of extant knowledge, emergent trends and research opportunities. To characterize the extant knowledge, we review relevant literature in the first half of the chapter and highlight the notion that startup operations are subject to three distinctive operational constraints on, or lack thereof, resources, routines (or processes), and reputation — also referred to as 3Rs in this chapter — that are affected by the capabilities of entrepreneurs as well as the uncertain, dynamic and complex environment they face. We codify these ideas in terms of five 3R principles that are uniquely tied to startup operations. In the second half of the chapter, we draw upon anecdotal evidence from connectivity based analytics and low cost intelligent robotics to identify emergent trends in terms of unique operational innovations that are enabling, and co-evolving with, business model innovation in startup settings. The chapter ends with a discussion of managerial implications and promising research avenues.