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Your search keyword '"Khudoerkov RM"' showing total 3 results
Start Over Author "Khudoerkov RM" Publisher rossiiskaia akademiia nauk
3 results on '"Khudoerkov RM"'

1. [Total protein content and concentration in the neurons of the "mirror" epileptiform focus in the rat brain at the late stages of its existence].

Author

Khudoerkov RM

Subjects
Animals, Brain Chemistry, Cobalt administration & dosage, Male, Parietal Lobe metabolism, Rats, Seizures chemically induced, Thalamic Nuclei metabolism, Time Factors, Nerve Tissue Proteins analysis, Neurons, Efferent metabolism, Seizures metabolism
Abstract

The experimental lesion in rat brain was produced by the implantation of cobaltogelatin rod into the right parietalis anterior area. A quantitative measurement of total protein was made by microdensitometer in neurons controlateral to cobalt lesion at 112-115 days after cobalt implantation. In the experimental animals, protein content decreased in neurons of lamina III and V area parietalis anterior and the nucleus lateralis thalami by 6, 60 and 53%, resp. It has been concluded that different type neurons have different protein changes in response to paroxyzmal activity at late stages of epileptogenic mirror focus.

Published
1979

2. [Cytochemical characteristics of proteins in the lateral nucleus of the rat thalamus (model of a mirror epileptogenic focus)].

Author

Khudoerkov RM

Subjects
Animals, Cobalt, Histocytochemistry, Rats, Seizures chemically induced, Temporal Lobe metabolism, Nerve Tissue Proteins metabolism, Seizures metabolism, Thalamic Nuclei metabolism
Abstract

The experimental lesion in rat brain was produced by the implantation of cobalt-gelatin rod into right parietalis anterior area. In this area, paroxymal discharges were determined by electroencephalography on the 11th day after the operation. On the 63rd day, paroxyzmal discharges were more severe. Quantitative measurements of proteins were made by microdensitometer in neurons of nucleus lateralis thalami controlateral to the cobalt lesion. On days 11 and 63 after the operation protein concentrations in the neurons were lowered by 35 and 44%, respectively. The size of neurons of the 11th day supassed the control value by 33%; it demonstrated a tendency to normalization by the 63rd day after cobalt lesion.

Published
1977

3. [Cytochemical research on the effect of a synthetic enkephalin analog on the protein content and enzyme activity of neurons].

Author

Gershteĭn LM, Sergutina AV, and Khudoerkov RM

Subjects
Acid Phosphatase metabolism, Aminopeptidases metabolism, Animals, Caudate Nucleus drug effects, Caudate Nucleus metabolism, Glutamate Dehydrogenase metabolism, Histocytochemistry, Male, Motor Cortex drug effects, Motor Cortex metabolism, Neurons metabolism, Rabbits, Rats, Rats, Inbred Strains, Time Factors, Enkephalins pharmacology, Nerve Tissue Proteins metabolism, Neurons drug effects, Oligopeptides pharmacology
Abstract

Using quantitative cytochemical technique a study was made of the effect of the synthetic analog of the Tyr-D-Ala-Gly-Phe-NH2 on the content and concentration of proteins and on the activity of enzymes (aminopeptidase, glutamate dehydrogenase and acid phosphatase) in neurons of the brain motor cortex and nucleus caudatus of rabbits and rats. The essential changes of the parameters used were registered 3 days after neuropeptide injection. A 30 minutes effects of the synthetic analog of enkephalins in protein metabolism was not so pronounced as a 3 days effect, the former being observed only in neurons of the brain motor cortex. Long-lasting effects of the neuropeptide Tyr-D-Ala-Gly-Phe-NH2 on the metabolism in brain are discussed.

Published
1985

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