1. APPARENTLY FIT BUT NOT HEALTHY - HIGH CARDIOVASCULAR RISK IN LEAN NAFLD PATIENTS.
- Author
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Rotaru, Adrian, Stafie, Remus, Stanciu, Carol, Zenovia, Sebastian, Stratina, Ermina, Nastasa, Robert, Minea, Horia, Singeap, Ana-Maria, Cojocaru, Camelia, Sfarti, Catalin, Girleanu, Irina, Chiriac, Stefan, Cuciureanu, Tudor, Huiban, Laura, Muzica, Cristina, and Trifan, Anca
- Subjects
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HEPATIC fibrosis , *NON-alcoholic fatty liver disease , *CARDIOVASCULAR diseases risk factors , *SYSTOLIC blood pressure , *TYPE 2 diabetes - Abstract
Background and Aims. Non-alcoholic fatty liver disease (NAFLD) and obesity are independently related to an increased risk for atherosclerotic cardiovascular disease (ASCVD), the primary cause of mortality in NAFLD patients. Even though many subjects with NAFLD are normal weight, it still remains uncertain whether their ASCVD risk is of major importance. The aim of this study is to assess and compare the ASCVD risk between lean and obese patients with NAFLD. Methods. Normal weight and obese patients were evaluated between January 2020 and February 2023 and their data was analyzed. NAFLD was diagnosed by vibration-controlled transient elastography (VCTE) with controlled attenuation parameter (CAP) and the American College of Cardiology/American Heart Association guidelines was used to evaluate the ASCVD risk. Results. In the obese group, 104 (63.8%) patients were diagnosed with NAFLD, compared to 32 (12.3%) in the lean population. In comparison to those with obese NAFLD, subjects with lean NAFLD had significantly higher ASCVD scores (mean 15.3% vs 22.7%, p<0.001). Moreover, subjects with lean NAFLD and significant liver fibrosis had a higher risk of ASCVD events, compared to their obese counterparts (OR, 2.51 vs 1.95, p=0.034). Regarding the presence of the components of the metabolic syndrome, the prevalence of type 2 diabetes mellitus was higher the obese group, while changes in the lipid profile and higher systolic blood pressure were more frequently found in lean subjects. Conclusions: Subjects with lean NAFLD had an ASCVD score that were significantly higher than those with obese NAFLD. In both study groups, the presence of significant liver fibrosis was an essential risk factor associated with an ASCVD event, but the effects were more pronounced in lean individuals. [ABSTRACT FROM AUTHOR]
- Published
- 2023