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Your search keyword '"Nussenzweig, Victor"' showing total 15 results
Start Over Author "Nussenzweig, Victor" Publisher rockefeller university press
15 results on '"Nussenzweig, Victor"'

1. Conservation of a Gliding Motility and Cell Invasion Machinery in Apicomplexan Parasites

Author

Kappe, Stefan, Bruderer, Thomas, Gantt, Soren, Fujioka, Hisashi, Nussenzweig, Victor, and Menard, Robert

Subjects
Parasites -- Research, Animal locomotion -- Research, Biological sciences
Abstract

Most Apicomplexan parasites, including the human pathogens Plasmodium, Toxoplasma, and Cryptosporidium, actively invade host cells and display gliding motility, both actions powered by parasite microfilaments. In Plasmodium sporozoites, thrombo-spondin-related anonymous protein (TRAP), a member of a group of Apicomplexan transmembrane proteins that have common adhesion domains, is necessary for gliding motility and infection of the vertebrate host. Here, we provide genetic evidence that TRAP is directly involved in a capping process that drives both sporozoite gliding and cell invasion. We also demonstrate that TRAP-related proteins in other Apicomplexa fulfill the same function and that their cytoplasmic tails interact with homologous partners in the respective parasite. Therefore, a mechanism of surface redistribution of TRAP-related proteins driving gliding locomotion and cell invasion is conserved among Apicomplexan parasites.

Published
1999

2. The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

Author

Zhang, Min, primary, Fennell, Clare, additional, Ranford-Cartwright, Lisa, additional, Sakthivel, Ramanavelan, additional, Gueirard, Pascale, additional, Meister, Stephan, additional, Caspi, Anat, additional, Doerig, Christian, additional, Nussenzweig, Ruth S., additional, Tuteja, Renu, additional, Sullivan, William J., additional, Roos, David S., additional, Fontoura, Beatriz M.A., additional, Ménard, Robert, additional, Winzeler, Elizabeth A., additional, and Nussenzweig, Victor, additional

Published
2010
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4. Mapping the Active Site of CD59

Author

Yu, Jinghua, primary, Abagyan, Ruben, additional, Dong, Shanghong, additional, Gilbert, Alexander, additional, Nussenzweig, Victor, additional, and Tomlinson, Stephen, additional

Published
1997
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5. The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

Author

Zhang, Min, Fennell, Clare, Ranford-Cartwright, Lisa, Sakthivel, Ramanavelan, Gueirard, Pascale, Meister, Stephan, Caspi, Anat, Doerig, Christian, Nussenzweig, Ruth S., Tuteja, Renu, Sullivan, William J., Roos, David S., Fontoura, Beatriz M. A., Ménard, Robert, Winzeler, Elizabeth A., and Nussenzweig, Victor

Subjects
enzymes and coenzymes (carbohydrates), environment and public health
Abstract

Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host. We show that sporozoite latency is an active process controlled by a eukaryotic initiation factor-2alpha (eIF2alpha) kinase (IK2) and a phosphatase. IK2 activity is dominant in salivary gland sporozoites, leading to an inhibition of translation and accumulation of stalled mRNAs into granules. When sporozoites are injected into the mammalian host, an eIF2alpha phosphatase removes the PO4 from eIF2alpha-P, and the repression of translation is alleviated to permit their transformation into liver stages. In IK2 knockout sporozoites, eIF2alpha is not phosphorylated and the parasites transform prematurely into liver stages and lose their infectivity. Thus, to complete their life cycle, Plasmodium sporozoites exploit the mechanism that regulates stress responses in eukaryotic cells.

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