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Your search keyword '"Matsuzawa, Kenji"' showing total 5 results
Start Over Author "Matsuzawa, Kenji" Publisher rockefeller university press
5 results on '"Matsuzawa, Kenji"'

3. TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

Author

Watanabe, Takashi, primary, Kakeno, Mai, additional, Matsui, Toshinori, additional, Sugiyama, Ikuko, additional, Arimura, Nariko, additional, Matsuzawa, Kenji, additional, Shirahige, Aya, additional, Ishidate, Fumiyoshi, additional, Nishioka, Tomoki, additional, Taya, Shinichiro, additional, Hoshino, Mikio, additional, and Kaibuchi, Kozo, additional

Published
2015
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4. Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration

Author

Wang, Shujie, primary, Watanabe, Takashi, additional, Matsuzawa, Kenji, additional, Katsumi, Akira, additional, Kakeno, Mai, additional, Matsui, Toshinori, additional, Ye, Feng, additional, Sato, Kazuhide, additional, Murase, Kiyoko, additional, Sugiyama, Ikuko, additional, Kimura, Kazushi, additional, Mizoguchi, Akira, additional, Ginsberg, Mark H., additional, Collard, John G., additional, and Kaibuchi, Kozo, additional

Published
2012
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5. Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.

Author

Shujie Wang, Watanabe, Takashi, Matsuzawa, Kenji, Katsumi, Akira, Kakeno, Mai, Matsui, Toshinori, Feng Ye, Sato, Kazuhide, Murase, Kiyoko, Sugiyama, Ikuko, Kimura, Kazushi, Mizoguchi, Akira, Ginsberg, Mark H., Collard, John G., and Kaibuchi, Kozo

Subjects
*CELL migration, *CYTOLOGICAL research, *CELL polarity, *PROTEIN kinase C, *PROTEIN kinases
Abstract

Migrating cells acquire front-rear polarity with a leading edge and a trailing tail for directional movement. The Rac exchange factor Tiam1 participates in polarized cell migration with the PAR complex of PAR3, PAR6, and atypical protein kinase C. However, it remains largely unknown how Tiam1 is regulated and contributes to the establishment of polarity in migrating cells. We show here that Tiam1 interacts directly with talin, which binds and activates integrins to mediate their signaling. Tiam1 accumulated at adhesions in a manner dependent on talin and the PAR complex. The interactions of talin with Tiam1 and the PAR complex were required for adhesion-induced Racl activation, cell spreading, and migration toward integrin substrates. Furthermore, Tiam1 acted with talin to regulate adhesion turnover. Thus, we propose that Tiam1, with the PAR complex, binds to integrins through talin and, together with the PAR complex, thereby regulates Rac1 activity and adhesion turnover for polarized migration. [ABSTRACT FROM AUTHOR]

Published
2012
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