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Start Over Author "Carmack C" Publisher rockefeller university press
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6. A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly.

Author

Wasserman R, Li YS, Shinton SA, Carmack CE, Manser T, Wiest DL, Hayakawa K, and Hardy RR

Subjects
Animals, B-Lymphocyte Subsets immunology, Bone Marrow Cells metabolism, Cell Differentiation genetics, Cell Differentiation immunology, Cells, Cultured, Fetus, Gene Expression Regulation, Developmental immunology, Humans, Immunoglobulin Heavy Chains biosynthesis, Immunoglobulin Heavy Chains genetics, Immunoglobulin mu-Chains biosynthesis, Immunoglobulin mu-Chains genetics, Liver cytology, Liver metabolism, Mice, Mice, Transgenic, Precipitin Tests, Receptors, Antigen, B-Cell genetics, Stem Cells immunology, Transfection, B-Lymphocyte Subsets cytology, B-Lymphocyte Subsets metabolism, Receptors, Antigen, B-Cell metabolism, Stem Cells cytology, Stem Cells metabolism
Abstract

The expression of different sets of immunoglobulin specificities by fetal and adult B lymphocytes is a long-standing puzzle in immunology. Recently it has become clear that production of immunoglobulin mu heavy chain and subsequent assembly with a surrogate light chain to form the pre-B cell receptor complex is critical for development of B cells. Here we show that instead of promoting pre-B cell progression as in adult bone marrow, this complex inhibits pre-B cell growth in fetal liver. Curiously, we identify a fetal-associated VH11 mu heavy chain that allows continued pre-B proliferation in fetal liver. Interestingly, this heavy chain does not associate efficiently with a surrogate light chain, providing a previously unrecognized mechanism for skewing the expression of distinctive VH genes toward fetal through early neonatal life.

Published
1998
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