1. [Two cases of primary malignant melanoma of the larynx: a rare pathology].
- Author
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Chaput B, De Bonnecaze G, Vergez S, Garrido I, Grolleau JL, and Benlyazid A
- Subjects
- Aged, 80 and over, Combined Modality Therapy, Disease Progression, Dysphonia etiology, Humans, Laryngeal Neoplasms pathology, Laryngeal Neoplasms radiotherapy, Laryngeal Neoplasms surgery, Laryngectomy, Lymph Node Excision, Male, Melanoma pathology, Melanoma radiotherapy, Melanoma surgery, Middle Aged, Neoplasm Recurrence, Local diagnosis, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local radiotherapy, Neoplasm Recurrence, Local surgery, Neoplasms, Second Primary diagnosis, Neoplasms, Second Primary pathology, Neoplasms, Second Primary radiotherapy, Neoplasms, Second Primary surgery, Prognosis, Radiotherapy, Adjuvant, Laryngeal Neoplasms diagnosis, Melanoma diagnosis
- Abstract
Introduction: Primary malignant melanoma of the larynx is a very rare entity. There are less than sixty cases described in the literature. Through both cases, we describe and discuss the clinical management of melanoma of the larynx., Clinical Cases: Two men aged 80 and 61 years were supported for MPL. The tumor was revealed by persistent dysphonia for the first. For the second, it was a second melanoma of laryngeal location. In both cases it was performed a total laryngectomy extended to the first tracheal rings with bilateral lymphadenectomy associated with adjuvant radiotherapy., Discussion: Excision margins with oncological safety are necessary to except a curative surgery. Still controversial, the adjuvant radiotherapy seems to provide a benefit in terms of local control. The place of targeted therapies remains unclear. However, no prognostic factor is currently clearly identified for this disease., Conclusion: Rare tumor, the MPL is associated with a very poor prognosis. Resective surgery followed by adjuvant radiotherapy is for us the treatment of choice.
- Published
- 2013