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Microdeletions and microduplications syndromes are a well defined group of disorders characterized by loss/ addition of less than 5 Mb of genetic material undetectable by simple karyotype and a particular phenotype. Our study presents the results of investigations of classical and molecular cytogenetic (FISH, Fluorescence in situ Hibridization) in 70 children showing different phenotypic manifestations, such as multiple congenital anomalies, dysmorphic appearance, mental retardation, obesity. After performing classical cytogenetic technique of the 70 cases, in four girls there were diagnosed two visible structural chromosomal abnormalities: DiGeorge syndrome, Distal 18q Deletion syndrome, 15q Duplication syndrome, izocromosome Xq and one boy with 11q24-qter deletion and 38 numerical aberrations were identified: 33 cases of trisomy 21, two cases of monosomy X, two cases of poly Y syndrome and one double aneuploidy, trisomy 21 and poly Y. Using FISH (Fluorescence in situ Hibridization) technique in all the 32 cases, another 5 cases were diagnosed with Prader-Willi syndrome, one with the following: Angelman syndrome, Williams syndrome and 15q Duplication Syndrome, two DiGeorge syndrome, one Jacobsen syndrome, 11q 23-qter deletion and one double aneuploidy. In our study, the efficacy of the classical cytogenetic technique in confirmation of the cases suspected by chromosome abnormality was 61.4% and the FISH technique, was 37,5%.In our study, using both methods of diagnosis, we obtained confirmation of the genetic etiology in only 72.85% of the cases.

Sutures are classified into non-absorbable and absorbable, and mechanical properties of these materials vary by the composition. In this study we analyze four different types of sutures used commonly in surgery: silk, nylon, polyglycolic acid (PGA) and polytetrafluoroethylene (PTFE). The materials were chosen to represent a wide range of suture material categories: absorbable and nonresorbable, monofilament and multifilament, natural and synthetic in order to assess their mechanical properties but also the bacterial adherence to each type. The objective of this study was to measure the total bacterial adherence by using real time PCR at 7 days postop and to analyze the antibacterial and mechanical properties comparatively depending on the type and composition of sutures. Tensile properties such as maximum tensile load, elongation rate, stiffness and energy absorbed before breakage were taken into consideration. Experimental determination pointed out that the average total bacterial load was lowest for PTFE and highest for silk. The results of the study are useful in choosing an appropriate suture wire according to the mechanical properties taking into account the bacterial load of the surgical site in order to aid in tissue repair.

This paper presents the research regarding determination of kinetic model parameters from a catalytic cracking process. Starting from the Weekman kinetic model, the authors proposed a simplified version of this model and, based on experimental data form a catalytic cracking plant, they have numerical determined the coefficients of the new kinetic model. For this purpose, there were defined two objective functions; the first function is based on errors generated by estimation of the riser outlet temperature and the second function associated to the errors generated by the estimation of the gasoline yield. The minimization of the two objective functions has been solve by using Optimization Toolbox from MATLAB programming language. The results showed that the objective function that depends on gasoline yield allows more accurate estimation of the kinetic parameters from this model.

This paper presents the research regarding determination of kinetic model parameters from a catalytic cracking process. Starting from the Weekman kinetic model, the authors proposed a simplified version of this model and, based on experimental data form a catalytic cracking plant, they have numerical determined the coefficients of the new kinetic model. For this purpose, there were defined two objective functions; the first function is based on errors generated by estimation of the riser outlet temperature and the second function associated to the errors generated by the estimation of the gasoline yield. The minimization of the two objective functions has been solve by using Optimization Toolbox from MATLAB programming language. The results showed that the objective function that depends on gasoline yield allows more accurate estimation of the kinetic parameters from this model. Keywords: kinetic model, optimization, catalytic cracking

Inflammation is a reflex reaction of the body to the action of some harmful agents, a reaction that manifests itself as a complex of functional and structural modifications of a vasculo-tisular nature, this reaction has occurred in the process of evolution. The intensity of the inflammatory reaction depends on the reactive properties of the body, the location of the inflammatory process, the anatomo-physiological particularities of the damaged tissue, and the conditions in which the inflammation develops. As accurate as dental technique and the practitioner�s skill, if the specific conditions of each patient are not taken into account, the benefit medical cannot rise to a higher level, with the final result being compromised by complications with unpredictable risks. Actinomycosis is a specific infection with subacute or chronic evolution, common to humans or animals, caused by microorganisms of the actinomycete family. The location of the affection in the cervico-facial sphere is four times bigger than the rest of the body; the disease is manifested by rough nodules, red in the cheek or sub-maxillary region, fistulas and scars on which new lesions appear. In order to achieve the proposed objectives, we conducted a study on a representative human sample of 158 patients, from the Oral and Maxillofacial Clinic, between 1.01.2013-31.12.2017. Risk factors (gender, age, area, dental anxiety score), our findings are unlikely to define separately the potential for the risk of installing actinomycosis. The level of dental anxiety as well as the general status of the patient are the markers that require the greatest attention from the practitioner in order to prevent a dental problem.

The main objectives of the present paper are to adaptation the five-kinetic model of the catalytic cracking process and simulation the riser to predicts the FCC products yields when one of the major input variable of the process is change. The simulation and adaptation are based on the industrial data from Romanian refinery. The adaptation is realize using a computational method from Optimization Toolbox from Matlab programming language. The new model can be used for optimization and control of FCC riser.

This study used a real-time PCR analysis to determine possible correlations between periodontal presence of human cytomegalovirus, Epstein-Barr virus and various putative parodontopathogenic bacteria. The study included 18 patients (aged 18-38 years) with aggressive periodontitis, 12 patients (ages 37 to 62) with chronic periodontitis and 30 periodontally healthy subjects (aged 21-54 years). Clinical periodontal evaluation included plaque index, gingival index, percentage of bleeding on probing sites, and probing depth. In each patient, a subgingival bacterial plaque sample was obtained from the deepest periodontal pocket. The real-time fluorogenic PCR detection system was used to determine the number of infectious agents. Human cytomegalovirus was detected in 17 sites with periodontal lesions and in two healthy periodontal sites, and the Epstein-Barr virus was detected in 19 sites with periodontal lesions and in 3 normal periodontal sites. Positive correlations were found between human cytomegalovirus and P. gingivalis, T. forsythia and C. rectus. The Epstein-Barr virus positively correlated with P. gingivalis and T. forsythia. Unfavorable changes in environmental exposure or alteration of the immune system genes can periodically suppress the host�s defence against periodontal aggression, which can then result in reactivation of resident herpesviruses and increased pro-inflammatory mediators followed by an increase in pathogenic bacteria.